Effect of treatment with original or biosimilar adalimumab on SARS-CoV2 vaccination antibody titers

Dokoupilová, Eva; Vetchý, David; Pavloková, Sylvie; Hanuštiaková, Markéta

doi:10.1016/j.ijpx.2024.100229

Cited by 1 publication

(1 citation statement)

References 45 publications

(54 reference statements)

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“…Subsequently, a study examined the impact of different treatments on SARS-CoV-2 antibody levels in patients with autoimmune rheumatic disease undergoing Pfizer/BioNTech mRNA vaccination [177]. Original adalimumab treatment resulted in stable antibody levels, whereas biosimilar adalimumab showed a significant decrease [177].…”

Section: Vaccine Development and Challengesmentioning

confidence: 99%

Unravelling Insights into the Evolution and Management of SARS-CoV-2

Mushebenge,

Ugbaja,

Mbatha

et al. 2024

BioMedInformatics

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Worldwide, the COVID-19 pandemic, caused by the brand-new coronavirus SARS-CoV-2, has claimed a sizable number of lives. The virus’ rapid spread and impact on every facet of human existence necessitate a continuous and dynamic examination of its biology and management. Despite this urgency, COVID-19 does not currently have any particular antiviral treatments. As a result, scientists are concentrating on repurposing existing antiviral medications or creating brand-new ones. This comprehensive review seeks to provide an in-depth exploration of our current understanding of SARS-CoV-2, starting with an analysis of its prevalence, pathology, and evolutionary trends. In doing so, the review aims to clarify the complex network of factors that have contributed to the varying case fatality rates observed in different geographic areas. In this work, we explore the complex world of SARS-CoV-2 mutations and their implications for vaccine efficacy and therapeutic interventions. The dynamic viral landscape of the pandemic poses a significant challenge, leading scientists to investigate the genetic foundations of the virus and the mechanisms underlying these genetic alterations. Numerous hypotheses have been proposed as the pandemic has developed, covering various subjects like the selection pressures driving mutation, the possibility of vaccine escape, and the consequences for clinical therapy. Furthermore, this review will shed light on current clinical trials investigating novel medicines and vaccine development, including the promising field of drug repurposing, providing a window into the changing field of treatment approaches. This study provides a comprehensive understanding of the virus by compiling the huge and evolving body of knowledge on SARS-CoV-2, highlighting its complexities and implications for public health, and igniting additional investigation into the control of this unprecedented global health disaster.

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Section: Vaccine Development and Challengesmentioning

confidence: 99%