Effect of Treatment with Inactive Vitamin D on the Intracranial Blood Flow in Patients with Chronic Obstructive Pulmonary Disease

Болотова, Е. В.; Трембач, В. В.; Дудникова, А. В.

doi:10.1134/s2079057020040049

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2023

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“…Genetic variants in these genes have been associated with albuminuria [ 98 ], which was recently associated with a greater decline in lung function [ 99 ]. Nevertheless, considering asthma as a risk factor for renal dysfunction remains controversial [ 100 ].…”

Section: Genomic Studiesmentioning

confidence: 99%

Genomics of Treatable Traits in Asthma

Espuela-Ortiz,

Martin-Gonzalez,

Poza-Guedes

et al. 2023

Genes

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The astounding number of genetic variants revealed in the 15 years of genome-wide association studies of asthma has not kept pace with the goals of translational genomics. Moving asthma diagnosis from a nonspecific umbrella term to specific phenotypes/endotypes and related traits may provide insights into features that may be prevented or alleviated by therapeutical intervention. This review provides an overview of the different asthma endotypes and phenotypes and the genomic findings from asthma studies using patient stratification strategies and asthma-related traits. Asthma genomic research for treatable traits has uncovered novel and previously reported asthma loci, primarily through studies in Europeans. Novel genomic findings for asthma phenotypes and related traits may arise from multi-trait and specific phenotyping strategies in diverse populations.

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Section: Genomic Studiesmentioning

confidence: 99%