1984
DOI: 10.1097/00006254-198407000-00019
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Effect of Treatment Regimens for Neisseria gonorrhoeae on Simultaneous Infection with Chlamydia trachomatis

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Cited by 51 publications
(69 citation statements)
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“…[20][21][22] This is primarily because of methodological difficulties: long-term follow-up of untreated chlamydia infection would be unethical, but if diagnosed infections are treated the natural history has been altered; studies conducted in hospital or clinic populations may be affected by selection bias; 21 objective diagnosis of pelvic inflammatory disease is difficult; 23 and chlamydia cannot be unequivocally established as the cause of any sequelae, particularly after the acute infection has resolved. Early studies in clinical populations suggested that about 30% of untreated cervical chlamydial infections resulted in pelvic inflammatory disease within a few weeks, 17,24 and that 20-25% of women with pelvic inflammatory disease from any cause went on to have an ectopic pregnancy or become infertile. 25 It is thought that about 50% of chlamydia infections resolve spontaneously within a year, [26][27][28] and up to 90% of diagnosed pelvic inflammatory disease might be managed in primary care.…”
Section: Chlamydia and Its Clinical Consequencesmentioning
confidence: 99%
See 1 more Smart Citation
“…[20][21][22] This is primarily because of methodological difficulties: long-term follow-up of untreated chlamydia infection would be unethical, but if diagnosed infections are treated the natural history has been altered; studies conducted in hospital or clinic populations may be affected by selection bias; 21 objective diagnosis of pelvic inflammatory disease is difficult; 23 and chlamydia cannot be unequivocally established as the cause of any sequelae, particularly after the acute infection has resolved. Early studies in clinical populations suggested that about 30% of untreated cervical chlamydial infections resulted in pelvic inflammatory disease within a few weeks, 17,24 and that 20-25% of women with pelvic inflammatory disease from any cause went on to have an ectopic pregnancy or become infertile. 25 It is thought that about 50% of chlamydia infections resolve spontaneously within a year, [26][27][28] and up to 90% of diagnosed pelvic inflammatory disease might be managed in primary care.…”
Section: Chlamydia and Its Clinical Consequencesmentioning
confidence: 99%
“…In the original model the occurrence of these sequelae was modelled statically because the most cited literature about the complications of chlamydial infection provides the data as a fixed probability. 24 Data were used from the Uppsala Women's Cohort Study, in which the cumulative incidences of pelvic inflammatory disease, ectopic pregnancy and infertility were estimated for a population of over 40,000 young women in Uppsala County, Sweden.…”
Section: Selecting a Modelling Approachmentioning
confidence: 99%
“…All were conducted in sexually transmitted diseases clinics amongst women at high risk of PID with short follow up periods. In two studies, women were coinfected with gonorrhoea and chlamydia [156,157] and in one study they were partners of men with nongonococcal urethritis [158]. PID was ascertained in women treated with antibiotics that were active against gonorrhoea but not chlamydia, or received placebo.…”
Section: Risk Of Female Reproductive Tract Morbidity Resulting From Cmentioning
confidence: 99%
“…Tubal damage occurs as a result of pelvic inflammatory disease (PID). PID is estimated to occur subsequent to Chlamydial infection in 10 -40% of cases (Stamm, Guinan et al 1984), however, the diagnosis of PID depends on presentation of symptoms and a proportion of infection is known to be silent and undiagnosed because it is asymptomatic (Paarvonen and Eggert-Kruse 1999). Therefore, in any individual case it is not possible to determine whether PID has occurred.…”
Section: Chlamydia -A Threat To Fertilitymentioning
confidence: 99%