Effect of treatment on the metabolism of tryptophan in childhood epilepsy.

Pyridoxine and Myoclonic Seizures

“…(Willoughby et al, 1966). Diminution of xanthurenic aciduria upon tryptophan loading when present in patients with infantile spasms treated with ACTH or steroids is usually noted (Jeune et al, 1959;Bower, 1961;Careddu et al, 1962;Hughes et al, 1967) rather than an increase, as in the presumably nonepileptic disorders studied by Altman.…”

“…Subsequently, many investigators have reported alterations in the pyridoxine-linked pathway from tryptophan to nicotinic acid in this syndrome. (French et al, 1965, References 33-39 and 41;Hughes et al, 1967).…”

Epilepsy as a Pyridoxine-Dependent Condition: Quantitative Urinary Biomarkers of Epilepsy. Family Disorders of Pyridoxine Metabolism

“…Disturbances of PLP-dependent tryptophan degradation, in particular over-excess of neurotoxic 3-HOKYN, have been repeatedly shown in epileptic patients starting from 50-s [38][39][40][41].…”

Academic paediatrics: Easter Island or Easter Sunday?

“…Earlier studies using pyridoxine in children resistant to what are now considered the older anticonvulsants have not shown very impressive responses. Livingston and colleagues 9 found no useful response in 31 children; Hagberg and colleagues 10 reported two out of 26 who achieved complete seizure control and others with improved control; Hughes and colleagues 11 found some improvement in four of ten patients, while Singh and Sinha 12 in a large Indian series reported seizure control in two out of 120. Jiao and colleagues 13 reported that adding pyridoxine to conventional treatment in acute symptomatic recurrent seizures of any cause improved outcome.…”