Effect of treatment of peripheral arterial disease on the onset of anaerobic exercise during cardiopulmonary exercise testing

Barkat, Mohamed; Key, Angela; Ali, Tamara; Walker, Paul; Duffy, Nick; Snellgrove, Jayne; Torella, Francesco

doi:10.14814/phy2.14815

Cited by 3 publications

(2 citation statements)

References 29 publications

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“…In this investigation, 12 week of SCT at the first VT increased

O 2peak by about 25% as well as 6MWT distances by about 25% (terminal distance) to 50% (pain-free distance), and decreased

E -

CO 2 slope. The improvement of

O 2peak in our exercise regimen was better than the 16% increase of

O 2peak in those underwent revascularization therapy ( Barkat et al, 2021 ) and the 13% increase of

O 2peak in those underwent 12-week of pain-free walking on treadmill ( Hiatt et al, 1994 ). These clinical observations imply that higher exercise intensity may be beneficial in cardiorespiratory fitness of PAD patients.…”

Section: Discussionmentioning

confidence: 79%

Supervised Cycling Training Improves Erythrocyte Rheology in Individuals With Peripheral Arterial Disease

Hsu

Lin

et al. 2022

Front. Physiol.

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Peripheral arterial disease (PAD) results in insufficient flow to lower extremities. Aerobic exercise provides health benefits for individuals with PAD, but basic science behind it is still debated. Twenty-one PAD patients aged about 70 years with female/male as 7/14 were recruited. Among them, 11 were randomized to have supervised cycling training (SCT) and 10 to receive general healthcare (GHC) as controls. SCT participants completed 36 sessions of SCT at the first ventilation threshold within 12 weeks and the controls received GHC for 12 weeks. Ankle-brachial index (ABI), 6-min walk test (6MWT), peak oxygen consumption (V˙O2peak), minute ventilation (V˙E), minute carbon dioxide production (V˙CO2), erythrocyte rheology, including the maximal elongation index (EImax) and shear stress at 50% of maximal elongation (SS1/2), and the Short Form-36 (SF-36) questionnaire for quality of life (QoL) were assessed before and 12 weeks after initial visit. SCT significantly decreased the SS1/2 as well as SS1/2 to EImax ratio (SS1/2/EImax) and increased the erythrocyte osmolality in the hypertonic region as well as the area under EI-osmolality curve. The supervised exercise-induced improvement of erythrocyte deformability could contribute to the increased peripheral tissue O2 delivery and was possibly related with increased V˙O2peak. The physiological benefit was associated with significantly increased ABI, 6-min walking distance, cardiorespiratory fitness, and SF-36 score. However, no significant changes in aerobic capacity and erythrocyte rheological properties were observed after 12-week of GHC. In conclusion, SCT improves aerobic capacity by enhancing erythrocyte membrane deformability and consequently promotes QoL in PAD patients.

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“…In this investigation, 12 week of SCT at the first VT increased

O 2peak by about 25% as well as 6MWT distances by about 25% (terminal distance) to 50% (pain-free distance), and decreased

E -

CO 2 slope. The improvement of

O 2peak in our exercise regimen was better than the 16% increase of

O 2peak in those underwent revascularization therapy ( Barkat et al, 2021 ) and the 13% increase of

Section: Discussionmentioning

confidence: 79%

Supervised Cycling Training Improves Erythrocyte Rheology in Individuals With Peripheral Arterial Disease

Hsu

Lin

et al. 2022

Front. Physiol.

View full text Add to dashboard Cite

show abstract

“…Effective revascularization of peripheral artery disease by VO2 (Oxygen delivery) while cardiopulmonary exercise testing (CEPT) has been examined by Barkat et al 17 This study performed a prospective cohort study on thirty patients who have undergone CEPT before and after iliofemoral PAD treatment. Furthermore, the immediate result was the difference in oxygen delivery at the Lactate threshold (LT) before and after revascularization.…”

Section: Introductionmentioning

confidence: 99%

A cross-sectional study on coronary artery disease diagnosis in patients with peripheral artery disease

Bhalke¹,

Hiremath²,

Makhale³

2022

Journal of Interventional Medicine

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Effects of additional exercise therapy after a successful vascular intervention for people with symptomatic peripheral arterial disease

Cucato,

Longano,

Perren

et al. 2024

Cochrane Database of Systematic Reviews

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Effect of treatment of peripheral arterial disease on the onset of anaerobic exercise during cardiopulmonary exercise testing

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 3 publications

References 29 publications

Supervised Cycling Training Improves Erythrocyte Rheology in Individuals With Peripheral Arterial Disease

Supervised Cycling Training Improves Erythrocyte Rheology in Individuals With Peripheral Arterial Disease

A cross-sectional study on coronary artery disease diagnosis in patients with peripheral artery disease

Effects of additional exercise therapy after a successful vascular intervention for people with symptomatic peripheral arterial disease

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