Effect of treat-to-target strategies on bone erosion progression in early rheumatoid arthritis: An HR-pQCT study

Yue, Jiang; Griffith, James F.; Xu, Jiankun; Fan, Xiaoxi; Shi, Lin; Wang, Defeng; Wong, Priscilla; Li, Edmund K.; Li, Martin; Li, Tena K; Mak, Wah Yan; Zhu, Tracy Y.; Hung, Vivian Wing‐Yin; Qin, Ling; Tam, Lai‐Shan

doi:10.1016/j.semarthrit.2018.05.001

Cited by 12 publications

(19 citation statements)

References 56 publications

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“…This is a sub‐study of the Hong Kong ERA vascular study which is a single‐center, randomized controlled trial designed to assess the effect of 2 tight control treatment strategies on vascular stiffness in patients with early RA (clinicaltrial.gov no: NCT01768923) . The protective effects of achieving sustained simplified disease activity score (SDAI) remission (SDAI ≤ 3.3 at months 6, 9 and 12) on erosion volume progression by HR‐pQCT have been published . The current sub‐study focused on the mechanisms of bone erosion progression assessed by HR‐pQCT.…”

Section: Methodsmentioning

confidence: 99%

“…X‐rays of the hands and feet were done at baseline and after 1 year. As no major differences were found in clinical and erosion parameters between both groups, a post‐hoc analysis was performed by combining the results from both groups to determine whether miRNA expression at baseline was associated with severity of erosion at baseline and erosion progression after 1 year. The study was conducted according to the Declaration of Helsinki and approved by the joint Chinese University of Hong Kong‐New Territories East Cluster Clinical Research Ethics Committee (CRE 2011.483‐T).…”

Section: Methodsmentioning

confidence: 99%

“…Erosion repair was defined as an erosion showing both: (a) a decrease in erosion volume exceeding the SDC; and (b) an increase in marginal osteosclerosis exceeding the SDC. Erosions which did not fulfil either the progression or repair criteria were classified as stable erosions …”

Section: Methodsmentioning

confidence: 99%

“…11 The protective effects of achieving sustained simplified disease activity score (SDAI) remission (SDAI ≤ 3.3 at months 6, 9 and 12) on erosion volume progression by HR-pQCT have been published. 12 The current sub-study focused on the mechanisms of bone erosion progression assessed by HR-pQCT. Briefly, 117 consecutive ambulatory Chinese ERA patients whose symptom duration was below 24 months were recruited from the rheumatology clinic of the Prince of Wales Hospital and other hospitals in Hong Kong.…”

Section: Patientsmentioning

confidence: 99%

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Circulating miR‐99b‐5p as a novel predictor of erosion progression on high‐resolution peripheral quantitative computed tomography in early rheumatoid arthritis: A prospective cohort study

et al. 2019

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Objectives To compare micro RNA (miRNA) expression: (a) between healthy individuals and early rheumatoid arthritis (ERA) patients with and without erosion on high‐resolution peripheral quantitative computed tomography (HR‐pQCT) at baseline; and (b) to explore whether these miRNAs could inform a signature predictive of erosion progression despite treatment with conventional synthetic disease‐modifying antirheumatic drugs (csDMARDs). Methods The second metacarpophalangeal head (MCP2) was scanned by HR‐pQCT at baseline and 1 year in 117 ERA patients. We performed global profiling of 377 miRNAs in 10 ERA patients with and without erosion on HR‐pQCT at baseline and six healthy controls. Validation of the miRNAs of interest were conducted using TaqMan® quantitative real‐time polymerase chain reaction in the validation ERA cohort (n = 117) at baseline. Correlation between the candidate miRNAs and erosion progression over 1 year were also assessed. Results In the 377 screened miRNAs, 94 (60.6%) miRNAs were upregulated in patients with erosions, with 13 (8.4%) upregulated more than 2‐fold. Sixty‐one (39.4%) miRNAs were downregulated in patients with erosions, with 6 (3.9%) downregulated more than 2‐fold. Expression of miR‐143‐3p, miR‐145‐5p and miR‐99b‐5p were significantly higher in the plasma of ERA patients with erosions compared with those without erosions. Logistic regression analysis revealed that the baseline expression of miR‐99b‐5p was an independent predictor of erosion progression at month 12 (Exp [B] = 4.257, 95% CI 1.178‐15.386, P = 0.027). Conclusions Differential expressions of circulating miR‐143‐3p, miR‐145‐5p and miR‐99b‐5p in the plasma of ERA patients may characterize a severe form of the disease. MiR‐99b‐5p, in particular, may serve as a possible predictor for erosion progression.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Patientsmentioning

confidence: 99%

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Circulating miR‐99b‐5p as a novel predictor of erosion progression on high‐resolution peripheral quantitative computed tomography in early rheumatoid arthritis: A prospective cohort study

et al. 2019

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“…Fifteen studies have reported longitudinal changes in the number and/or size of erosions. Of these, three investigated PsA (14,49,66), 10 investigated patients with RA (6,10,15,29,42,46,58,59,64,65), and one study examined ACPA+ individuals without arthritis (62). Seven studies investigated intervention with different therapies either as an open-label study or secondary analysis in a randomized controlled trial.…”

Section: Longitudinal Changes Of the Pathological Measuresmentioning

confidence: 99%

High-Resolution Peripheral Quantitative Computed Tomography for Bone Evaluation in Inflammatory Rheumatic Disease

et al. 2020

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High resolution peripheral quantitative computed tomography (HR-pQCT) is a 3-dimensional imaging modality with superior sensitivity for bone changes and abnormalities. Recent advances have led to increased use of HR-pQCT in inflammatory arthritis to report quantitative volumetric measures of bone density, microstructure, local anabolic (e.g., osteophytes, enthesiophytes) and catabolic (e.g., erosions) bone changes and joint space width. These features may be useful for monitoring disease progression, response to therapy, and are responsive to differentiating between those with inflammatory arthritis conditions and healthy controls. We reviewed 69 publications utilizing HR-pQCT imaging of the metacarpophalangeal (MCP) and/or wrist joints to investigate arthritis conditions. Erosions are a marker of early inflammatory arthritis progression, and recent work has focused on improvement and application of techniques to sensitively identify erosions, as well as quantifying erosion volume changes longitudinally using manual, semi-automated and automated methods. As a research tool, HR-pQCT may be used to detect treatment effects through changes in erosion volume in as little as 3 months. Studies with 1-year follow-up have demonstrated progression or repair of erosions depending on the treatment strategy applied. HR-pQCT presents several advantages. Combined with advances in image processing and image registration, individual changes can be monitored with high sensitivity and reliability. Thus, a major strength of HR-pQCT is its applicability in instances where subtle changes are anticipated, such as early erosive progression in the presence of subclinical inflammation. HR-pQCT imaging results could ultimately impact decision making to uptake aggressive treatment strategies and prevent progression of joint damage. There are several potential areas where HR-pQCT evaluation of inflammatory arthritis still requires development. As a highly sensitive imaging technique, one of the major challenges has been motion artifacts; Klose-Jensen et al. HR-pQCT for Inflammatory Rheumatic Disease motion compensation algorithms should be implemented for HR-pQCT. New research developments will improve the current disadvantages including, wider availability of scanners, the field of view, as well as the versatility for measuring tissues other than only bone. The challenge remains to disseminate these analysis approaches for broader clinical use and in research.

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Classifying Remission in Rheumatoid Arthritis Treat‐to‐Target Studies: Comment on the Article by Norvang et al

Xie

Zhang

2020

Arthritis & Rheumatology

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Effect of treat-to-target strategies on bone erosion progression in early rheumatoid arthritis: An HR-pQCT study

Cited by 12 publications

References 56 publications

Circulating miR‐99b‐5p as a novel predictor of erosion progression on high‐resolution peripheral quantitative computed tomography in early rheumatoid arthritis: A prospective cohort study

Circulating miR‐99b‐5p as a novel predictor of erosion progression on high‐resolution peripheral quantitative computed tomography in early rheumatoid arthritis: A prospective cohort study

High-Resolution Peripheral Quantitative Computed Tomography for Bone Evaluation in Inflammatory Rheumatic Disease

Classifying Remission in Rheumatoid Arthritis Treat‐to‐Target Studies: Comment on the Article by Norvang et al

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