Effect of Transient Post-transplantation Hyperglycemia on the Development of Diabetes Mellitus and Transplantation Outcomes in Kidney Transplant Recipients

Park, S.-C.; Yoon, Y.-D.; Jung, Hee-Yeon; Kim, K.-H.; Choi, Ji-Young; Park, S.-H.; Kim, C.-D.; Kim, Y.-L.; Kim, H.-K.; Huh, Seung; Cho, J.-H.

doi:10.1016/j.transproceed.2014.11.053

Cited by 21 publications

(12 citation statements)

References 19 publications

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“…In recent years, availability of transplant patient data has allowed for analyses to better understand the pre-transplant risk factors for PTDM [13][14][15][16][17][18][19][20][21]. However, these studies come from a wide range of hospitals and health systems, and typically focus on a single organ cohort such as kidney transplantations.…”

Section: Introductionmentioning

confidence: 99%

Comparison of post-transplantation diabetes mellitus incidence and risk factors between kidney and liver transplantation patients

et al. 2020

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BackgroundMost prior studies characterizing post-transplantation diabetes mellitus (PTDM) have been limited to single-cohort, single-organ studies. This retrospective study determined PTDM across organs by comparing incidence and risk factors among 346 liver and 407 kidney transplant recipients from a single center. MethodsUnivariate and multivariate regression-based analyses were conducted to determine association of various risk factors and PTDM in the two cohorts, as well as differences in glucometrics and insulin use across time points.

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Section: Introductionmentioning

confidence: 99%

Comparison of post-transplantation diabetes mellitus incidence and risk factors between kidney and liver transplantation patients

et al. 2020

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“…This type of diabetes mellitus affects allograft survival and also cardiovascular complications and overall patient survival. The incidence of PTDM after kidney transplantation varies from 5.5% to 60.2% of recipients 1,2. The occurrence of PTDM in the early posttransplant period suggests that the risk factors exist or develop at the time of or prior to transplantation.…”

Section: Introductionmentioning

confidence: 99%

Genetic factors in pathogenesis of diabetes mellitus after kidney transplantation

Tarnowski¹,

Słuczanowska-Głąbowska²,

Pawlik³

et al. 2017

TCRM

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Posttransplant diabetes mellitus (PTDM) is one of the major metabolic complications after transplantation of solid organs including the kidney. This type of diabetes mellitus affects allograft survival, cardiovascular complications and overall patient survival. The modifiable risk factors that contribute to PTDM include obesity, some viral infections (eg, hepatitis C virus, cytomegalovirus) and especially immunosuppressive drugs including corticosteroids, tacrolimus, cyclosporine and sirolimus. Currently, predisposing genetic factors have been considered important in PTDM development. The commonly evaluated genetic determinants include genes encoding transcription factors, cytokines, chemokines, adipokines, ionic channels, glucose transporters, cytochrome P450 enzymes and other enzymes metabolizing drugs, drug transporters. Unfortunately, the results of studies are inconclusive and differ between populations. There is a need for large genome-wide association study to identify the genetic risk factors associated with PTDM development.

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“…The endpoint of this study was PTDM 1 year after transplantation. We chose the 1-year time point because (i) glucocorticoids are discontinued in our centre in all patients 3 months after transplantation and (ii) transient posttransplantation hyperglycaemia is usually resolved 1 year after transplantation, and does not predict PTDM [40]. PTDM was defined according to the American Diabetes Association as a fasting blood glucose >7.0 mmol/L, or a non-fasting blood glucose >11.1 mmol/L [41,42].…”

Section: Outcomementioning

confidence: 99%

Serum magnesium, hepatocyte nuclear factor 1β genotype and post-transplant diabetes mellitus: a prospective study

Burgh

Moes

Kieboom

et al. 2019

Nephrology Dialysis Transplantation

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Background Retrospective studies suggest that tacrolimus-induced hypomagnesaemia is a risk factor for post-transplant diabetes mellitus (PTDM), but prospective studies are lacking. Methods This was a prospective study with measurements of serum magnesium and tacrolimus at pre-specified time points in the first year after living donor kidney transplantation (KT). The role of single nucleotide polymorphisms (SNPs) in hepatocyte nuclear factor 1β (HNF1β) was also explored because HNF1β regulates insulin secretion and renal magnesium handling. Repeated measurement and regression analyses were used to analyse associations with PTDM. Results In our cohort, 29 out of 167 kidney transplant recipients developed PTDM after 1 year (17%). Higher tacrolimus concentrations were significantly associated with lower serum magnesium and increased risk of hypomagnesaemia. Patients who developed PTDM had a significantly lower serum magnesium trajectory than patients who did not develop PTDM. In multivariate analysis, lower serum magnesium, age and body mass index were independent risk factors for PTDM. In recipients, the HNF1β SNP rs752010 G > A significantly increased the risk of PTDM [odds ratio (OR) = 2.56, 95% confidence interval (CI) 1.05–6.23] but not of hypomagnesaemia. This association lost significance after correction for age and sex (OR = 2.24, 95% CI 0.90–5.57). No association between HNF1β SNPs and PTDM was found in corresponding donors. Conclusions A lower serum magnesium in the first year after KT is an independent risk factor for PTDM. The HNF1β SNP rs752010 G > A may add to this risk through an effect on insulin secretion rather than hypomagnesaemia, but its role requires further confirmation.

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Effect of Transient Post-transplantation Hyperglycemia on the Development of Diabetes Mellitus and Transplantation Outcomes in Kidney Transplant Recipients

Cited by 21 publications

References 19 publications

Comparison of post-transplantation diabetes mellitus incidence and risk factors between kidney and liver transplantation patients

Comparison of post-transplantation diabetes mellitus incidence and risk factors between kidney and liver transplantation patients

Genetic factors in pathogenesis of diabetes mellitus after kidney transplantation

Serum magnesium, hepatocyte nuclear factor 1β genotype and post-transplant diabetes mellitus: a prospective study

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