Effect of transfusion in acute chest syndrome of sickle cell disease

Acute Chest Syndrome in Sickle Cell Disease in Saudi Arab Children in the Eastern Province

“…21 In ACS, simple blood transfusion may be beneficial in shortening the clinical course and decreasing mortality. [22][23][24] In this study, the use of simple blood transfusion in 74% of admissions may have contributed to rapid improvement of our patients.…”

Corticosteroids and increased risk of readmission after acute chest syndrome in children with sickle cell disease

“…However, neither study assessed predictors of readmission nor the impact of more recently proposed therapies for ACS, including high-dose dexamethasone and preemptive transfusion [1,6]. Currently, the use of simple or exchange transfusion, antibiotics, oxygen, and bronchodilators for wheezing is the standard of care for severe (and perhaps moderate) ACS, based on improvement in oxygenation and other clinical parameters [2,7,8]. However, transfusion has not been evaluated in a clinical trial and was associated with a new red cell antibody in 2.4% of patients in a prospective study of ACS [2].…”

Therapeutic Approaches of Acute Thoracic Syndrome in Patients with Falciform Disease

“…Acute respiratory failure can develop abruptly, since early blood transfusion of the simple type when hemoglobin levels are less than 50 g/L is extremely important because it aims to achieve an ideal concentration of 100-110 g/L. Although most STA patients respond adequately to simple transfusions, some studies show an efficacy of transfusion transfusions as first-line therapy in STA [33][34][35][36]. Blood transfusion does not occur frequently, and your choice should be based on the patient's clinical status, noting that the patient is deteriorating relatively quickly.…”