Effect of transforming growth factor β on postoperative adhesion formation and intact peritoneum

Williams, Robert; Rossi, Ann Marie; Chegini, Nasser; Schultz, Gregory S.

doi:10.1016/0022-4804(92)90280-d

Cited by 128 publications

(62 citation statements)

References 9 publications

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“…In humans, proliferative vitreoretinopathy of the eye is also associated with elevated TGF-3 levels (41) as are various fibrotic skin diseases including systemic sclerosis (42,43) and eosinophilia-myalgia syndrome (44). Recently, intraperitoneal administration of TGF-3 to rats was shown to markedly increase the formation of postoperative adhesions (45). The role ofTGF-f in scarring is particularly interesting.…”

Section: Tgf-f3 In Fibrotic Diseases Ofother Organsmentioning

confidence: 99%

Transforming growth factor-beta in disease: the dark side of tissue repair.

Border¹,

Ruoslahti²

1992

J. Clin. Invest.

1,057

599

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Section: Tgf-f3 In Fibrotic Diseases Ofother Organsmentioning

confidence: 99%

Transforming growth factor-beta in disease: the dark side of tissue repair.

Border¹,

Ruoslahti²

1992

J. Clin. Invest.

1,057

599

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“…The transforming growth factor-beta 1 (TGF-ß1) plays a major role in stimulating ECM [9][10][11]. Frequent peritonitis occurrence may cause persistent TGF-ß1 mRNA expression [11,12].…”

Section: Introductionmentioning

confidence: 99%

Persistent Transforming Growth Factor-Beta 1 Expression May Predict Peritoneal Fibrosis in CAPD Patients with Frequent Peritonitis Occurrence

et al. 1998

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The efficiency of continuous ambulatory peritoneal dialysis depends on the permeability of the peritoneal membrane. Peritoneal fibrosis (PF) causes loss of the dialytic function. Several studies have indicated that PF is closely related to the proliferation of peritoneal fibroblasts and the deposition of extracellular matrix. Transforming growth factor-beta 1 (TGF-β1) plays a major role in stimulating extracellular matrix deposition. Frequent peritonitis occurrence may cause persistent TGF-β1 mRNA expression. In an attempt to search for a factor related to PF, we designed a longitudinal study to measure TGF-β1 levels in dialysate and TGF-β1 mRNA expression in peritoneal mononuclear cells from peritoneal dialysate before onset, once a week during peritonitis, and after peritonitis in high and low peritonitis occurrence (HPO and LPO) patients. Fifteen patients with a LPO rate and 5 patients with a HPO rate were followed up longitudinally. Meanwhile, TGF-β1 levels and TGF-β1 mRNA expression were augmented in peritoneal dialysate effluents before, during, and after the episodes of peritonitis. The peritoneal permeability was evaluated by the peritoneal equilibration test. The results revealed that in the LPO group, TGF-β1 and TGF-β1 mRNA were detectable at early stages of peritonitis, but the levels decreased rapidly and were undetectable 2 weeks after peritonitis. On the other hand, in the HPO group, TGF-β1 and TGF-β1 mRNA persisted for a long time. We could detect TGF-β1 and TGF-β1 mRNA in dialysate effluents and peritoneal mononuclear cells even 2, 3, and 4 weeks after episodes of peritonitis. When compared with that of first or second episode of peritonitis, the peritoneal function evaluated with the peritoneal equilibration test was found to obviously deteriorate during the third episode of peritonitis. These findings were confirmed by an in situ hybridization technique to evaluate the relationship between TGF-β1 mRNA expression and PF from biopsied peritoneal specimens. These findings suggest that the high TGF-β1 levels in the dialysate are related to an increased expression of TGF-β1 in the peritoneum. Thus, the persistent TGF-β1 expression in the peritoneum may serve as a useful parameter in predicting PF in continuous ambulatory peritoneal dialysis patients with frequent peritonitis occurrence.

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“…Experimental models in rats have pointed to a promoting role of TGF-β in postoperative adhesion formation (22,23). Transforming growth factor-β1 could act by stimulating cell-cell and cell-matrix interactions (24).…”

Section: Discussionmentioning

confidence: 99%

Adhesion of endometrial cells labeled with 111Indium-tropolonate to peritoneum: a novel in vitro model to study endometriosis

Béliard

Noël

Goffin

et al. 2003

Fertility and Sterility

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Objective: To evaluate, in a new original in vitro assay, putative factors that could modulate the adhesion of endometrial cells to peritoneum. Design: Prospective, controlled in vitro study. Setting: Academic research laboratory. Result(s):The adhesion of human endometrial cells to mouse peritoneum was increased by treatment with proinflammatory cytokines (interleukin IL-1 β, IL-6, TNF α, TGF-β1). Whereas heparan sulfate had no effect on cell adhesion, a gel of ferric hyaluronate (Intergel) was able to counteract the pro-adhesive effect of cytokines. Interestingly, the pretreatment of peritoneum with cytokines, 24 hours before cell seeding in the presence of the ferric hyaluronate gel, restored the cytokine-promoting effect on cell adhesion. Conclusion(s):Proinflammatory cytokines promote the in vitro peritoneal adhesion of endometrial cells. An antiadhesive hyaluronate gel used in clinics decreases the adhesion in a dose-dependent manner and reduces cytokine bioavailability.

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Effect of transforming growth factor β on postoperative adhesion formation and intact peritoneum

Cited by 128 publications

References 9 publications

Transforming growth factor-beta in disease: the dark side of tissue repair.

Transforming growth factor-beta in disease: the dark side of tissue repair.

Persistent Transforming Growth Factor-Beta 1 Expression May Predict Peritoneal Fibrosis in CAPD Patients with Frequent Peritonitis Occurrence

Adhesion of endometrial cells labeled with 111Indium-tropolonate to peritoneum: a novel in vitro model to study endometriosis

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