Effect of Transcutaneous Electrical Stimulation on Rabbit Corneal Epithelial Cell Migration

Ghaffarieh, Alireza; Ghaffarpasand, Fariborz; Dehghankhalili, Maryam; Honarpisheh, Nazafarin; Nirumandi, Samira; Tanideh, Nader

doi:10.1097/ico.0b013e31823f8b2a

Cited by 10 publications

(5 citation statements)

References 22 publications

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“…Different groups of cells, including neural crest cells ( 34 , 35 ), fibroblasts ( 33 ), neurons ( 36 , 37 ), and CECs ( 38 – 40 ), respond to electric fields by directed migration or directed growth in vitro . This has been shown to increase the rate of cornea healing in cornea abrasions in a vivo model of corneal wound healing in rabbits ( 10 ). It is also hypothesized that QMR can stimulate the lacrimal system, reactivate the lacrimal and meibomian gland tissue and benefit the ocular annexes ( 5 ).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the expression of matrix metalloproteinase and the infiltration of leukocytes were reduced, supporting an anti-inflammatory effect ( 5 ). Electrical stimulation has been hypothesized to affect cell migration and proliferation ( 7 – 10 ), and accelerate nerve regeneration via the promotion of neurotrophic factors such as brain-derived neurotrophic factor and nerve growth factor with the influx of calcium into neurons ( 11 ).…”

Section: Introductionmentioning

confidence: 99%

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Quantum molecular resonance electrotherapy (Rexon-Eye) for recalcitrant dry eye in an Asian population

Foo,

Liu,

Tho

et al. 2023

Front. Med.

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ObjectivesTo assess the safety, efficacy, patients’ satisfaction and acceptability of Rexon-Eye electrotherapy in treating Asian severe dry eye disease (DED) patients.MethodsProspective parallel-arm pilot study recruiting 40 DED Chinese patients with >moderate recalcitrant DED (Contact Lens Research Unit [CCLRU] > grade 2). Subjects were randomized into 2 groups, undergoing four weekly treatment sessions each: group 1 received full treatment power; group 2 received control treatment (power 1 treatment). Non-invasive tear break-up time (NIBUT), cornea fluorescein staining graded via CCLRU and Schirmer’s I test were compared pre- and 2 months post-treatment. The SPEED and QUEST questionnaires that evaluated subjective symptoms and treatment satisfaction, respectively, at baseline and 2 weeks post-treatment were carried out. Tear cytokine levels in both groups were examined at 2 weeks post-treatment.ResultsThe amount of improvement in post-treatment corneal staining in the inferior corneal zone was significant in Group 1 (p = 0.038) but not in Group 2 (p = 0.832). Group 1 eyes with worse baseline staining (total score >9.8) had a significantly greater reduction of corneal staining than those with better baseline staining (−11.7 ± 1.98 vs. −4.6 ± 2.89, p < 0.001). There were no other significant differences in NIBUT, Schirmer’s 1 and cornea fluorescein staining grading within or between the groups.: Group 1 (n = 24) had improved subjective dryness scores compared to Group 2 (n = 16) (SPEED score: 6.38 + 4.16 vs. 10.0 + 6.36, p = 0.04). No significant differences were seen in 11 tear cytokine levels at 2 weeks post-treatment between the 2 groups.ConclusionIn Asian DED patients treated with Rexon-Eye, inferior cornea staining showed significant improvement compared to placebo, and eyes with greater cornea staining at baseline achieved a greater improvement in staining. There were no other significant improvements in NIBUT and Schirmer’s 1. Rexon-Eye also improved subjective DED scores in 41.7% of eyes without any adverse effects.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Quantum molecular resonance electrotherapy (Rexon-Eye) for recalcitrant dry eye in an Asian population

Foo,

Liu,

Tho

et al. 2023

Front. Med.

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“…While no studies have reported on an ICT modality for ocular pain, we found four reports describing the use of TENS in the setting of ocular pathology and two that studied the effects of TENS in ocular pain (33)(34)(35)(36). Although the latter two reported pain relief, the first of these investigated the more invasive subcutaneous application of electrical current and the second from 1991 involved only ten cases in the setting of acute surgical pain (33,34).…”

Section: Introductionmentioning

confidence: 99%

Noninvasive Electrical Stimulation for the Treatment of Chronic Ocular Pain and Photophobia

Sivanesan

Levitt

Sarantopoulos

et al. 2018

Neuromodulation: Technology at the Neural Interface

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Our data indicate that TENS may similarly provide analgesia in patients with dry eye symptoms as it does for many other chronic pain conditions. Furthermore, the noted effect on symptoms of photophobia and dryness suggest that all may be linked by similar trigeminal-thalamic-cortical pathways. Prospective studies with electrical stimulation of dry eye are needed to further elucidate its benefit and mechanism of action.

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“…Magnetic therapy with an extremely low-frequency electromagnetic frequency complements is a noninvasive, safe, and simple method for healing injuries from a variety of causes (6). Ghaffarieh et al discovered that magnetic treatment of corneal chemical burns significantly reduced the ulcerative area when compared to control groups, particularly in the first week of therapy, and that its effectiveness was comparable to medical therapy (12). The success of a single case report is, of course, limited, and it is critical to confirm the current findings with additional findings from additional studies.…”

Section: Discussionmentioning

confidence: 99%

Bioresonance Treatment of Intractable Corneal Ulcer

Imanzade

Shafaeizadeh

Dadpay

et al. 2021

Ann Mil Health Sci Res

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Introduction: A bioresonance-based complementary treatment for corneal ulcers is described to determine whether an electromagnetic field can improve intractable corneal ulcers. Case Presentation: The patient was a 65-year-old man who was suffered from corneal ulcer. The wound was burned five times with laser surgery; however, there was no significant improvement in the patient's condition. He had been treated for a year with electromagnetic frequency complements. Conclusions: Since bioresonance therapy can heal the corneal ulcer in this patient, we advised patients to perform this treatment.

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Effect of Transcutaneous Electrical Stimulation on Rabbit Corneal Epithelial Cell Migration

Abstract: The transcutaneous application of electrical stimulation can considerably increase the rate of corneal healing, especially in the first 24 hours of healing full surface corneal abrasion.

Cited by 10 publications

References 22 publications

Quantum molecular resonance electrotherapy (Rexon-Eye) for recalcitrant dry eye in an Asian population

Quantum molecular resonance electrotherapy (Rexon-Eye) for recalcitrant dry eye in an Asian population

Noninvasive Electrical Stimulation for the Treatment of Chronic Ocular Pain and Photophobia

Bioresonance Treatment of Intractable Corneal Ulcer

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