Effect of Transcranial Magnetic Stimulation on Action Naming in Patients With Alzheimer Disease

Cotelli, Maria; Manenti, Rosa; Cappa, Stefano F.; Geroldi, Cristina; Zanetti, Orazio; Rossini, Paolo Maria; Miniussi, Carlo

doi:10.1001/archneur.63.11.1602

Cited by 192 publications

(189 citation statements)

References 21 publications

Supporting

Mentioning

175

Contrasting

Unclassified

Order By: Relevance

“…Although ECT could be useful to induce Homer1a expression, especially promising may be transcranial magnetic stimulation (TMS), a noninvasive milder version of ECT that has been used safely for treatment of major depression or for research on cognitive function (O'Reardon et al, 2007;Rossi et al, 2009). In fact, TMS-induced improvement of action naming, a cognitive task, in AD patients has been reported (Cotelli et al, 2006). Molecular and cellular underpinnings of this cognitive improvement are not known at all, although the present study suggests that the anticipated Homer1a expression by TMS may be involved.…”

Section: Homer1a Counteracts Bk Channel Suppression By Intracellular A␤mentioning

confidence: 99%

Suppression of a Neocortical Potassium Channel Activity by Intracellular Amyloid-β and Its Rescue with Homer1a

Yamamoto¹,

Ueta²,

Wang³

et al. 2011

J. Neurosci.

View full text Add to dashboard Cite

It is proposed that intracellular amyloid-␤ (A␤), before extracellular plaque formation, triggers cognitive deficits in Alzheimer disease (AD). Here we report how intracellular A␤ affects neuronal properties. This was done by injecting A␤ protein into rat and mouse neocortical pyramidal cells through whole-cell patch pipettes and by using 3xTg AD model mice, in which intracellular A␤ is accumulated innately. In rats, intracellular application of a mixed A␤ 1-42 preparation containing both oligomers and monomers, but not a monomeric preparation of A␤ 1-40 , broadened spike width and augmented Ca 2ϩ influx via voltage-dependent Ca 2ϩ channels in neocortical neurons. Both effects were mimicked and occluded by charybdotoxin, a blocker of large-conductance Ca 2ϩ -activated K ϩ (BK) channels, and blocked by isopimaric acid, a BK channel opener. Surprisingly, augmented Ca 2ϩ influx was caused by elongated spike duration, but not attributable to direct Ca 2ϩ channel modulation by A␤ 1-42 . The A␤ 1-42 -induced spike broadening was blocked by electroconvulsive shock (ECS), which we previously showed to facilitate BK channel opening via expression of the scaffold protein Homer1a. In young 3xTg and wild mice, we confirmed spike broadening by A␤ 1-42 , which was again mimicked and occluded by charybdotoxin and blocked by ECS. In Homer1a knock-out mice, ECS failed to block the A␤ 1-42 effect. Single-channel recording on BK channels supported these results. These findings suggest that the suppression of BK channels by intracellular A␤ 1-42 is a possible key mechanism for early dysfunction in the AD brain, which may be counteracted by activity-dependent expression of Homer1a.

show abstract

Section: Homer1a Counteracts Bk Channel Suppression By Intracellular A␤mentioning

confidence: 99%

Suppression of a Neocortical Potassium Channel Activity by Intracellular Amyloid-β and Its Rescue with Homer1a

Yamamoto¹,

Ueta²,

Wang³

et al. 2011

J. Neurosci.

View full text Add to dashboard Cite

show abstract

“…High-frequency rTMS to the left DLPFC results in reduced action naming latencies in young subjects (Cappa, Sandrini, Rossini, Sosta, & Miniussi, 2002), and in an increased number of correct responses for action naming in patients with mild Alzheimer's disease (AD), for both classes of stimuli (actions and objects) in moderate-to-severe AD patients (Cotelli et al, 2006;Cotelli, Manenti, Cappa, Zanetti, & Miniussi, 2008). Moreover, in an off-line study, a significant effect of left DLPFC stimulation (25 minutes/ day for 5 days/week for 4 weeks) on language functioning, together with a lasting benefit at 6 months, was also found in an AD patient sample (Cotelli et al, 2011).…”

Section: Rationale For Choosing the Dlpfc As The Rtms Target Areamentioning

confidence: 99%

Anomia training and brain stimulation in chronic aphasia

Cotelli

Fertonani

Miozzo

et al. 2011

Neuropsychological Rehabilitation

Self Cite

View full text Add to dashboard Cite

Recent studies have reported enhanced performance on language tasks induced by non-invasive brain stimulation, i.e., repetitive transcranial magnetic stimulation (rTMS), or transcranial direct current stimulation (tDCS), in patients with aphasia due to stroke or Alzheimer's disease (AD). The first part of this article reviews brain stimulation studies related to language recovery in aphasic patients. The second part reports results from a pilot study with three chronic stroke patients who had non-fluent aphasia, where real or placebo rTMS was immediately followed by 25 minutes of individualised speech therapy. Real rTMS consisted of high-frequency rTMS over the left dorsolateral prefrontal cortex (BA 8/9) for 25 minutes. Each patient underwent a total of four weeks of intervention. P1 underwent four weeks of real rTMS (5 days/week) where individualised speech therapy was provided for 25 minutes immediately following each rTMS session. P2 and P3 each underwent two weeks of placebo rTMS, followed immediately by individualised speech therapy; then two weeks of real rTMS, followed immediately by individualised speech therapy. Assessments took place at 2, 4, 12, 24 and 48 weeks post-entry/baseline testing. Relative to entry/baseline testing, a significant improvement in object naming was observed at all testing times, from two weeks post-intervention in real rTMS plus speech therapy, or placebo rTMS plus speech therapy. Our findings suggest beneficial effects of targeted behavioural training in combination with brain stimulation in chronic aphasic patients. However, further work is required in order to verify whether optimal combination parameters (rTMS alone or speech therapy alone) and length of rTMS treatment may be found.

show abstract

“…For instance, repetitive TMS can increase or decrease cortical excitability, inducing inhibition at frequencies ≤1 Hz or facilitation at ≥ 5 Hz. Cotelli et al (2006) found that administering an rTMS intervention during which both the left and right dorsolateral prefrontal cortex was stimulated in 15 patients diagnosed with mild to moderate AD significantly improved these patients' ability to name actions. In another study, Cotelli et al (2008) have shown that rTMS improved naming of actions and objects in 24 patients in the advanced stage of AD.…”

Section: Imaging the Impact Of Language Training On Post-stroke Brainmentioning

confidence: 96%

Language Reorganization After Stroke: Insights from fMRI

Kljajević¹

2012

Functional Magnetic Resonance Imaging - Advanced Neuroimaging Applications

View full text Add to dashboard Cite

Effect of Transcranial Magnetic Stimulation on Action Naming in Patients With Alzheimer Disease

Cited by 192 publications

References 21 publications

Suppression of a Neocortical Potassium Channel Activity by Intracellular Amyloid-β and Its Rescue with Homer1a

Suppression of a Neocortical Potassium Channel Activity by Intracellular Amyloid-β and Its Rescue with Homer1a

Anomia training and brain stimulation in chronic aphasia

Language Reorganization After Stroke: Insights from fMRI

Contact Info

Product

Resources

About