Effect of Transcorneal Electrical Stimulation in Patients with Nonarteritic Ischemic Optic Neuropathy or Traumatic Optic Neuropathy

Fujikado, Takashi; Morimoto, Takeshi; Matsushita, Kazunobu; Shimojo, Hiroshi; Okawa, Yoshihiro; Tano, Yasuo

doi:10.1007/s10384-005-0304-y

Cited by 125 publications

(94 citation statements)

References 15 publications

(13 reference statements)

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“…The adverse effects were infrequent and mild for both DTL-Plus and ERG-Jet electrodes, with few patients reporting either foreignbody sensations with the DTL-Plus electrode 36 or mild transient corneal punctate keratopathy on slit-lamp examination after the use of the ERG-Jet electrode. 38 Schatz et al 36 also reported minor conjunctiva irritation after intraocular pressure measurements. Other clinical TES studies reported slight corneal superficial punctuate keratopathy, 41 transient superficial keratitis, 39 and foreignbody sensations in three patients.…”

Section: Complications and Safety Profilementioning

confidence: 95%

“…TES treatment performed >4 months after the onset of nonarteritic ischemic optic neuropathy exhibited improved visual acuity in two of three eyes examined. 38 Although visual acuity became impaired some months after the patients stopped receiving ES, after a second TES treatment, the vision improved again. This finding suggests a causal relationship between the treatment and visual improvement.…”

Section: The Effects Of Tes In Clinical Studiesmentioning

confidence: 96%

“…33,38 For example, in rats, the proposed current intensity of TES for protection of photoreceptors (300 mA, 3 milliseconds per phase) is higher than that for survival of RGCs (100 mA, 1 millisecond per phase). 26,30 However, in humans, the threshold intensity required to elicit phosphene in both the central and peripheral visual fields is generally between 300 and 900 mA.…”

Section: Challenges and Future Perspectivesmentioning

confidence: 99%

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Electrical Stimulation as a Means for Improving Vision

Sehic

Guo

Cho

et al. 2016

The American Journal of Pathology

134

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Evolving research has provided evidence that noninvasive electrical stimulation (ES) of the eye may be a promising therapy for either preserving or restoring vision in several retinal and optic nerve diseases. In this review, we focus on minimally invasive strategies for the delivery of ES and accordingly summarize the current literature on transcorneal, transorbital, and transpalpebral ES in both animal experiments and clinical studies. Various mechanisms are believed to underlie the effects of ES, including increased production of neurotrophic agents, improved chorioretinal blood circulation, and inhibition of proinflammatory cytokines. Different animal models have demonstrated favorable effects of ES on both the retina and the optic nerve. Promising effects of ES have also been demonstrated in clinical studies; however, all current studies have a lack of randomization and/or a control group (sham). There is thus a pressing need for a deeper understanding of the underlying mechanisms that govern clinical success and optimization of stimulation parameters in animal studies. In addition, such research should be followed by large, prospective, clinical studies to explore the full potential of ES. Through this review, we aim to provide insight to guide future research on ES as a potential therapy for improving vision. (Am J Pathol 2016 http://dx

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Section: Complications and Safety Profilementioning

confidence: 95%

Section: The Effects Of Tes In Clinical Studiesmentioning

confidence: 96%

Section: Challenges and Future Perspectivesmentioning

confidence: 99%

See 1 more Smart Citation

Electrical Stimulation as a Means for Improving Vision

Sehic

Guo

Cho

et al. 2016

The American Journal of Pathology

134

View full text Add to dashboard Cite

show abstract

“…Fujikado reported on efficacy of a single stimulation session in eight patients with nonarteritic ischemic and traumatic optic neuropathy [21]. Inomata treated three patients with longstanding retinal artery occlusion, and found benefits in visual acuity and visual field area [22], and Oono has detected amelioration of multifocal ERG parameters and visual field parameters in his series of eight patients with fresh or longstanding branch retinal artery occlusion (RAO) [23].…”

Section: Clinical Studiesmentioning

confidence: 99%

Electrical stimulation — a therapeutic strategy for retinal and optic nerve disease?

Gekeler¹,

Bartz‐Schmidt²

2012

Graefes Arch Clin Exp Ophthalmol

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“…5 In clinical studies, TES has been shown to improve visual acuity (VA) and/or VF in patients with various neuroretinal diseases, including retinal artery occlusion (RAO), nonarteritic ischemic optic neuropathy, Best vitelliform macular dystrophy, and traumatic optic neuropathy. [6][7][8][9][10] TES also leads to improved electroretinography (ERG) findings and VF in patients with retinitis pigmentosa. 11 To date, however, no information is available concerning the long-term therapeutic effects of TES on glaucoma.…”

Section: Introductionmentioning

confidence: 99%