Effect of Tranexamic Acid on Transfusion Requirement in Dual Antiplatelet-Treated Anemic Patients Undergoing Off-Pump Coronary Artery Bypass Graft Surgery - A Randomized Controlled Study -

Blood Component Use in a Sub-Saharan African Country: Results of a 4-Year Evaluation of Diagnoses Associated With Transfusion Orders in Namibia

“…In industrialized countries, many surveys have been conducted to document blood use in a number of clinical settings, including surgical wards [1], trauma departments [2,3], and large academic or regional medical centers [4][5][6][7]. Other studies in industrialized settings have evaluated blood use to plan for demographic shifts related to an aging population [8] or the impact of transfusion alternatives [9][10][11][12][13]. Beyond blood stock management, transfusion services in developed countries have also studied blood use to track the appropriate use of transfusions [14,15], the impact of interventions, such as training [16,17], or the introduction of new technologies on physicians' blood prescribing practices [18].…”

Guidelines for the use of platelet transfusions

“…In contrast, TXA has been used in three RCTs in patients taking clopidogrel (with or without aspirin) before coronary artery bypass grafting (total 766 patients) and significantly reduced blood transfusion requirements (Ahn et al , ; Shi et al , ,b). No differences in adverse events were reported between the groups; however, the authors advised caution regarding the small numbers and limited follow‐up (in the two largest studies follow‐up was for 1 year).…”

The safety and efficiency of intravenous administration of tranexamic acid in coronary artery bypass grafting (CABG): A meta-analysis of 28 randomized controlled trials

“…The characteristics of included studies were shown in [12,14,[16][17][18][23][24][25][26]28,[30][31][32]34,36,38,39], off-pump condition in 9 trails [3,10,11,15,27,29,33,35,37] and both condition in 2 trails [4,8].…”

“…An increasing number of studies that investigated the effectiveness and safety of TXA in CABG surgery have been conducted in recent years with varying results [8,[10][11][12][13][14][15][16][17][18]. Therefore, we conducted a meta-analysis of existing studies to estimate the safety and efficiency of TXA in CABG surgery focusing on the incidence of postoperative cerebrovascular accident, seizures and reoperation for bleeding.…”