Effect of Tranexamic Acid Irrigation on Perioperative Blood Loss During Orthognathic Surgery: A Double-Blind, Randomized Controlled Clinical Trial

Prevention of Bleeding in Orthognathic Surgery—A Systematic Review and Meta-Analysis of Randomized Controlled Trials

“…We acknowledge that a total sample size of 288 study participants is low and larger samples could prove useful, especially for print & web 4C=FPO 9 897 898 899 900 901 902 903 904 905 906 907 908 909 910 911 912 913 914 915 916 917 918 919 920 921 922 923 924 925 926 927 928 929 930 931 932 933 934 935 936 937 938 939 940 941 942 943 944 945 946 947 948 949 950 951 952 953 954 955 956 957 958 959 960 961 962 963 964 965 966 967 968 969 970 971 972 973 974 975 976 977 978 979 980 981 982 983 984 985 986 987 988 989 990 991 992 993 994 995 996 997 998 999 1000 1001 1002 1003 1004 1005 1006 1007 1008 studies on topical TXA, because these only accounted for 2 trials (n = 96). 21,28 Thus, the hemostatic capacity of IV TXA in OS is fairly well established, but the level of evidence for its topical application remains scarce. In support of the latter route of administration, the study by Sindet-Pedersen et al 32 demonstrated that rinses of 5% TXA secur...…”

Tranexamic acid in epistaxis: a systematic review

“…A large ( n = 400) well‐designed trial found that topical TXA applied post‐adenoidectomy in children reduced blood loss and primary haemorrhage rate. In oral surgery, irrigation with topical TXA or postoperative TXA mouthwash has been shown to reduce blood loss. Surgical site irrigation with topical TXA is also used in intra‐articular orthopaedic surgery and coronary artery bypass surgery.…”

Topical biomaterials to prevent post-tonsillectomy hemorrhage

“…Y Surgicel® [77]N for othersBismuth subgallate-basedBSG- adrenaline paste, BSG- phenylephrine hydrochloride mixtureY [78]Y (BSG mixed with phenylephrine hydrochloride) [79]Y BSG with adrenaline for primary PTH [80], N for secondary PTH [81]N [81]Clinical study on patients underwent tonsillectomy [78, 81]Spectrum Chemical (powder), mixing 26 g of BSG powder to 20 ml of normal saline with 0.7 ml of 1:1000 adrenalinePost-opdecreases operating time by significantly reducing the hemostasis time and the number of ligatures [78, 81]; accelerates the cascade of blood clotting [79]; accelerate the intrinsic clotting pathway through the activation of factor XII (Hageman factor) [82]. Y [62]Antifibrinolyticstranexamic acid (TXA) liquidY [83, 84]N [83, 84]–Clinical reports analysis of 246 patients topically treated with TA and 248 control [84]Systematic review [83]Cyklokapron®Postopno device or site for infection, reduce intraoperative blood loss during Orthognathic Surgery, prevent postop hemorrhage after oral or dental surgery in hemophilia A patients and those on warfarin anticoagulation [85]N for Topical applicationNatural materialPropolis–Y [86]Y [86]Randomized controlled study on 65 patients [86]Topical propolis gelgargle immediately after surgery [86]accelerated wound healing of tonsillar fossaeNHerbal ingredientsY [87]––Clinical trial in 47 consecutive children patientsAnkaferd Blood Stopper®Intra-opsafe and efficient, and it reduces operating time [87], and contains no synthetic additives [88]NAutologous serum–Y [89]Y [89]A preliminary study on 32 patients (4–15 years old) [89]Centrifuge peripheral venous blood at 1500–2000 g for 10 min to separate the serum and then topically administeredIntra and post 8 and 24 hContributed to tonsillar fossa epithelizatio...…”