Effect of Traditional Chinese Medicine on Psoriasis Vulgaris: A Meta-Analysis and Systematic Review

Abstract

Background: Psoriasis is a chronic, inflammatory autoimmune skin disease that affects 2%–3% of the world’s population. Lesions are mainly found on the limbs, trunk, and scalp, but may also affect other parts of the body, and the cause is not yet known. The chronic and relapsing nature of psoriasis makes it one of the most complex and important diseases in current dermatology research. Methods: The search was conducted using PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Internet, Wanfang Data, VIP journals database, and Chinese biomedical literature database (CBM). The retrieval time limit was from the establishment of the database to January 2021. The quality of the selected literature were evaluated, and ReView Manager 5.3 was used for Meta-analysis after randomized controlled trials were filtered. Results: Finally, 16 randomized controlled trials involving 1967 patients were included. The total effective rate (OR =3.68,95% CI[2.73,4.95], P<0.00001), cure rate (OR =2.01, 95% CI[1.62,2.49]c, P <0.00001), and PASI score (OR =-1.83, 95% CI[-2.39, -1.26], P <0.00001) of the traditional Chinese medicine (TCM) were superior than the Diyin tablet.. Conclusion: In the treatment of psoriasis, traditional Chinese medicine (TCM) shows higher efficacy than the Diyin tablet. However, due to the limitations of the included literature, we still need more double-blind, placebo-controlled trials with large samples and multiple centers to provide high-quality clinical evidence.

Exploration on the Clinical Medication Pattern and Mechanism of Psoriasis Vulgaris Based on Data Mining and Network Pharmacology

“…The complexity of psoriasis vulgaris only 1990 to 2019 global psoriasis incidence increased by 26.53%, male and female ratio in the 50-54 years age group reached the peak, in addition to genetic factors and environmental factors, caused by the recurrence of the disease by the role of multi-factors to the current public health and safety pose many challenges [7,8] . The clinical deterioration and onset of psoriasis vulgaris is often combined with a variety of diseases, the use of Chinese medicine multi-effective overall regulation of the advantages of metabolic diseases, such as the use of blood circulation and stasis of the use of traditional Chinese medicine, the use of a more effective clinical effect [9,10] .…”

Effect of fire needle combined with traditional Chinese medicine on psoriasis: A systematic review and meta-analysis

“…Currently, there are oral preparations, topical drugs, phototherapy, and biological agents; however, their clinical effects are not ideal. [7] Although treatment can temporarily…”

“…Currently, there are oral preparations, topical drugs, phototherapy, and biological agents; however, their clinical effects are not ideal. [ 7 ] Although treatment can temporarily relieve symptoms, the recurrence rate after drug discontinuation is high. Moreover, drugs are generally expensive and the economic burden caused by long-term or even lifelong treatment seriously affects patients’ daily life, reducing their quality of life, and is not conducive to ensuring patient compliance, thus affecting wide promotion of medicine in clinical practice.…”

Effect of Chinese herbal medicine injections for treatment of psoriasis vulgaris: a systematic review and meta-analysis

“…Chinese herbal medicine, utilized in clinical practice in Asian countries for centuries, has demonstrated efficacy and safety in alleviating psoriasis symptoms and reducing adverse reactions, as mentioned by numerous studies ( Dai et al, 2022 ; Lu et al, 2022 ). CHM encompasses various forms, including CHM granules, baths, and injections (CHMIs).…”