Effect of Total Treatment Time on Event-Free Survival in Carcinoma of the Cervix

Jf, Delaloye; Coucke, Philippe; Pampallona, Sandro; Grandi, P. De

doi:10.1006/gyno.1996.0009

Cited by 19 publications

(6 citation statements)

References 14 publications

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“…First, the overall treatment period is short. Several studies have shown that overall treatment time is a significant prognostic factor for patients with cervical cancer treated with radiation therapy alone (Fyles et al, 1992;Girinsky et al, 1993;Lanciano et al, 1993;Perez et al, 1995; Radiation therapy alone for carcinoma of the uterine cervix T Ota et al Delaloye et al, 1996). Fyles et al (1992) reported the influence of treatment duration on local control.…”

Section: Discussionmentioning

confidence: 99%

Treatment of squamous cell carcinoma of the uterine cervix with radiation therapy alone: long-term survival, late complications, and incidence of second cancers

et al. 2007

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The objective of this retrospective study was to determine the survival rate, incidence of late complications, and incidence of second cancers when radiation therapy alone is used for carcinoma of the uterine cervix. Between 1971 and 1995, 1495 patients with squamous cell carcinoma of the uterine cervix (stages I -IV) were treated with radiation therapy alone in our hospital. Radiation therapy consisted of a combination of high-dose-rate intracavitary brachytherapy and external beam radiotherapy. The cumulative 5-year survival rates for stages Ib, II, and III/IVa carcinoma were 93.5, 77.0, and 60.3%, respectively, and the 10-year survival rates were 90.9, 74.5, and 56.1%, respectively. Local control rates for stages Ib, II, and III/IVa carcinoma were 92.0, 79.4 and 64.2%, respectively. Eighty-two (5.5%) patients suffered grade III/IV or V (fatal) complications. A second cancer developed in 13 (0.87%) patients. Second cancers were observed most frequently in the rectum (five cases), colon (three cases), and uterine body (two cases). Long-term follow-up data revealed that our method of radiation therapy alone for locally advanced carcinoma of the uterine cervix is effective, with low incidences of late complications and second cancers.

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Section: Discussionmentioning

confidence: 99%

Treatment of squamous cell carcinoma of the uterine cervix with radiation therapy alone: long-term survival, late complications, and incidence of second cancers

et al. 2007

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“…Studies of the increase in tumor control dose with increasing treatment time suggest that after a variable lag period, surviving tumor clonogens regenerate rapidly during fractionated radiation therapy to the extent that each additional day of treatment requires *0.6 Gy, on average, to offset clonogenic cell regeneration, again suggesting a clonogenic cell doubling time of 3.5-5 days [5]. Many trials have conclusively proven overall treatment time to be a major determinant in the outcome in cervix cancer [6][7][8][9][10][11]. The usual recommendation is to complete treatment by 8 weeks (56 days) [12].…”

Section: Discussionmentioning

confidence: 99%

Pure Accelerated Radiation Versus Concomitant Chemoradiation in Selected Cases of Locally Advanced Carcinoma Cervix: A Prospective Study

Roy

Choudhury

Pal

et al. 2012

J Obstet Gynecol India

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Objective This non-randomized study was conducted to assess and compare the response and safety of true accelerated radiation alone to concomitant chemoradiation in locally advanced squamous cell carcinoma of the uterine cervix. Methods Sixty patients with locally advanced squamous cell carcinoma of the uterine cervix, FIGO Stages (2009) IB2-IIIB were non-randomized to receive six fractions per week of external beam radiation (EBRT) (will be henceforth referred to as Arm A or Study arm or pure accelerated radiation arm) and five fractions per week of EBRT and chemotherapy with inj cisplatin 40 mg/m 2 i.v. every

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“…Optimal treatment for recurrent disease is still a debate. Most recurrences occur within 5 years [90], but recurrences beyond 5 years of radiation have been described [91]. Patients with early disease who undergo appropriate treatment have recurrence risk of 10-15%, mostly isolated in pelvic cavity [92].…”

Section: Prognosismentioning

confidence: 99%

Early Stage Cervical Cancer, Therapy for Reproductive Health and Quality Survival

Chhabra¹

2016

MEDJ

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Cervical cancer, one of the leading causes of cancer deaths, seventh in frequency amongst all the cancers, third most common cancer in women, after breast and colorectal cancers, accounts for 9% of all cancers in women and 4% of cancers in men and women put together. As cervical cancer is being reported in young women, so preservation of reproductive health and survival with quality has become more important during cervical cancer therapy. For quality survival, reproductive health preservation inspite of cancer, early diagnosis and appropriate therapy are essential. Purpose of this article is to share so that others also look into various issues and we try to do the best for prevention of cervical cancer and provide best therapy so that women have survival with quality and reproductive health is preserved, specially in young women. Review of literature was done and self experiences have been added. BACKGROUNDCervical cancer is the seventh in frequency amongst all the cancers, third most common cancer after the breast and colorectal cancers, one of the leading causes of cancer deaths among women, specially in developing countries, including India. It accounts for 9% of all cancers in women, 4% of cancers in men and women put together. It is estimated that 530,000 new cases of cervical cancer must have been diagnosed in 2008 [1 -3]. Worldwide, cervical cancer causes around 275,000 deaths per year, 80% in the countries with limited resources [4]. Though it is a preventable cancer, but continues to be a major cause of cancer related deaths globally. However if it is detected in early stage, death can be prevented, quality life is possible and even reproductive health can be preserved by appropriate therapy. Population-based studies from developed countries have shown marked socioeconomic gradients in the incidence and mortality due to cervical cancer. Women from lower socioeconomic strata have 2-3 fold higher risk to have cervical cancer than their affluent counterparts [5 -10]. The difference is mainly because of the availability and utility of screening programs but it could also be related to other causes including diet. Most of the cases of the cervical cancer are because of infection with the human papilloma virus (HPV) and experts believe that a diet high in antioxidants, carotenoids, flavonoids, and folate found in fruits and vegetables can help the body fight HPV and also prevent conversion of cervical cells into cancerous cells by HPV. A study revealed that women who had high levels of certain chemical compounds indicating diet rich in fruits and vegetables were able to clear their HPV faster than their peers, reducing the risk of cancer [11]. It is number one cancer in women of East African and South Asian countries in terms of incidence as well as mortality [12]. More than eight out of ten (86%) cases and 88% deaths due to cervical cancer occur in developing countries [3]. It is our experience that in a nearby province where diet is different, disease seems to occur more often in young women and seems to g...

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Effect of Total Treatment Time on Event-Free Survival in Carcinoma of the Cervix

Cited by 19 publications

References 14 publications

Treatment of squamous cell carcinoma of the uterine cervix with radiation therapy alone: long-term survival, late complications, and incidence of second cancers

Treatment of squamous cell carcinoma of the uterine cervix with radiation therapy alone: long-term survival, late complications, and incidence of second cancers

Pure Accelerated Radiation Versus Concomitant Chemoradiation in Selected Cases of Locally Advanced Carcinoma Cervix: A Prospective Study

Early Stage Cervical Cancer, Therapy for Reproductive Health and Quality Survival

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