Effect of Topiramate on Mitochondrial Biogenesis and Neuroinflammation in Chronic Constriction Injury and Streptozotocin-induced Peripheral Neuropathy
Abdulla K. Sherikar,
Aman B. Upaganlawar,
Chandrashekhar D. Upasani
Abstract:Background: Because neuropathic pain is currently a poorly understood medical condition, there is a need to identify a more effective therapeutic drug with a low toxicity profile. Purpose: To address the behavioural, oxidative stress, and cytokine-mediated inflammatory pathways involved in sciatic nerve, the current study protocol used Chronic Constriction Injury (CCI) and Streptozotocin (STZ) induced neuropathic pain methods. Materials and Methods: Following CCI to the sciatic nerve and administration of STZ … Show more
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