Effect of topical pergolide on aqueous dynamics in normal and glaucomatous monkeys

Turner

1989

1 The effects of a single oral dose of the dopaminergic agonists lisuride (0.1 mg), terguride (0.25 mg) and bromocriptine (1.25 mg) on IOP were studied in eight normal volunteers using the non-contact tonometer. 2 Considering all post-dose measurements, compared with placebo, bromocriptine and lisuride but not terguride reduced IOP significantly in both eyes. 3 There was no significant difference between the ocular hypotensive effect of bromocriptine and lisuride. 4 Terguride reduced IOP significantly in the left eye at the 3 h time point after drug administration. 5 The result of this study confirms the reported ocular hypotensive effect of bromocriptine and showed that lisuride is as effective as bromocriptine in reducing IOP. 6 To evaluate the clinical importance of these drugs as ocular hypotensive agents other studies are needed using eye drops.

Section: Resultsmentioning

confidence: 99%

“…Recently, cianergoline, another ergot derivative, has been reported to reduce intraocular pressure in rabbits and monkeys (Potter & Shumate, 1987). Using fluorophotometry in monkeys, it has been shown that pergolide reduced IOP by inhibiting aqueous humour formation (Siegel et al, 1987).…”

Section: Introductionmentioning

confidence: 99%

The effects of lisuride, terguride and bromocriptine on intraocular pressure (IOP).

Turner

1989

“…Although a large body of pharmacological evidence, in both animals (Potter & Burke, 1983;Siegel et al, 1987) and human normotensive (Al-Sereiti & Turner, 1989;Mekki et al, 1983) and glaucomatous (Geyer et al, 1987a) eyes, has been accumulating to support the involvement of a dopaminergic mechanism in regulating IOP, almost nothing has been done to identify dopamine receptors in the ciliary body and/or trabecular meshwork. The results of this study add to this evidence and support the finding that D2-receptor agonists reduce IOP and show that pergolide, in a single oral dose of 25 p.g, is a potent ocular hypotensive drug with no effect on pupil diameter.…”

Section: Discussionmentioning

confidence: 99%

“…Using fluoro- photometric and tonographic methods in normal and glaucomatous monkeys, it has been found that pergolide reduced aqueous humour formation (Siegel et al, 1987). It produced miosis in rabbits (Potter & Burke, 1983) and mydriasis in monkeys (Siegel et al, 1987).…”

Section: Introductionmentioning

confidence: 99%

The effect of a single oral dose of pergolide on intraocular pressure and pupil diameter.

Quik

Turner

1989

1. The ocular hypotensive effect of a single oral dose of 25 micrograms pergolide, a dopamine 2‐receptor agonist, was studied in 12 normal human volunteers, using a non‐invasive method. 2. An oral dose of timolol 20 mg was used as a positive control. 3. The effects of both drugs on pupil diameter were also studied, using a photographic method. 4. Considering the first 6 h post‐dosing measurements, using multiple linear regression analysis comparing drug with placebo and including the baseline values as continuous independent variables, both pergolide and timolol had a significant ocular hypotensive effect in both eyes (P less than 0.0001) with no significant effects on pupil diameter. 5. Further topical application studies in normal and glaucomatous eyes are needed to evaluate the usefulness of pergolide in the treatment of glaucoma.

“…Cianergoline (Potter & Shumate, 1987) and LY141865 (Potter & Burke, 1988), other ergot derivatives which are relatively selective D2-receptor agonists, have been reported to produce ocular hypotension in monkeys and rabbits. Using fluorophotometry in monkeys, it has been shown that pergolide reduced IOP by inhibiting aqueous humour formation (Siegel et al, 1987).…”

Section: Introductionmentioning

confidence: 99%

A comparison of the ocular hypotensive effect of 0.025% bromocriptine and 0.25% timolol eye drops in normal human volunteers.

Coakes

O'sullivan

et al. 1989

1 The ocular hypotensive effect of 0.025% bromocriptine and 0.25% timolol eye drops was compared in nine healthy human volunteers, using non-contact tonometry. 2 Considering all post-dosing measurements compared with placebo and including the baseline values as continuous independent variables, using multiple linear regression analysis, both bromocriptine and timolol had a significant ocular hypotensive effect (P < 0.0001) in the treated eye with a significant but lesser effect in the contralateral eye.3 In the concentrations used, timolol was more efficacious than bromocriptine in lowering intraocular pressure (P < 0.025). 4 Using other forms of vehicles for bromocriptine to improve efficacy and studying the ocular hypotensive effect of topical application of other dopamine-2-receptor agonists such as pergolide and lisuride was suggested.Keywords bromocriptine dopaminergic agonists intraocular pressure non-contact tonometer timolol