Effect of topical nasal steroid sprays on nasal mucosa and ciliary function

Verret, D. J.; Marple, Bradley F.

doi:10.1097/00020840-200502000-00005

Cited by 23 publications

(21 citation statements)

References 25 publications

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“…Moreover, this effect was noted with rather mild reductions of the pH from 7.4 to 6.0. Given the fact that the normal pH of the nose is slightly acidic, ranging from 5.5 to 6.0, it is reasonable that this factor might also contribute to relieving the toxicity of BKC observed in in vitro studies [10,13]. …”

Section: Discussionmentioning

confidence: 99%

The Effect of Topical Corticosteroids, Topical Antihistamines, and Preservatives on Human Ciliary Beat Frequency

Jiao

Meng

Zhang³

2014

ORL

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Background: The aim of this study was to investigate the effect of the corticosteroids, the antihistamines, and the preservatives benzalkonium chloride (BKC) and potassium sorbate (PS) in intranasal medications on human nasal epithelial ciliary beat frequency (CBF). Methods: Primary ciliated epithelial cell cultures from the human nasal mucosa of chronic sinusitis patients were established. Changes in CBF of epithelial cell cultures treated/untreated with intranasal medications or preservatives were assessed using high-speed digital imaging methods. Results: Budesonide caused a rapid but reversible ciliostasis and showed no ciliotoxic effect at 10% dilution. Fluticasone propionate induced an irreversible ciliostatic activity and showed a reversible decrease in CBF at 10% dilution. Azelastine hydrochloride and levocabastine hydrochloride both induced a dose-dependent and irreversible decrease in CBF, although the ciliotoxic effect was not evident at 5% dilution. BKC resulted in an irreversible ciliostasis at 0.005 or 0.01% concentrations, whereas PS did not show any change in CBF at 0.12 or 0.24% concentrations. Conclusions: Crystalline BKC and BKC-containing intranasal medications, including fluticasone propionate, azelastine hydrochloride and levocabastine hydrochloride, but not PS or PS-containing intranasal budesonide spray, led to irreversible ciliostasis in human nasal epithelial cell cultures when applied at clinically relevant concentrations.

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Section: Discussionmentioning

confidence: 99%

The Effect of Topical Corticosteroids, Topical Antihistamines, and Preservatives on Human Ciliary Beat Frequency

Jiao

Meng

Zhang³

2014

ORL

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“…Studies have showed that it can induce nasal mucociliary dysfunction, nasal irritation and hypersecretion, burning sensation, degenerative changes in supportive and olfactory cells, and squamous cell metaplasia (Steinsvag et al 1996; McMahon et al 1997; Hofmann et al 2004; Meltzer 2007). However, the clinical impact of these effects on the nasal mucosa is unclear (Braat et al 1995; Bernstein 2000; Marple et al 2004; Verret and Marple 2005). Perhaps the nasal toxicity of benzalkonium chloride could be neutralized by nasal secretions and corticosteroids actions (Riechelmann et al 2004).…”

Section: Fluticasone Furoatementioning

confidence: 99%

Fluticasone furoate nasal spray in the treatment of allergic rhinitis

Giavina‐Bianchi¹

2008

TCRM

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Allergic rhinitis (AR) is a prevalent disease with great morbidity and signifi cant societal and economic burden. Intranasal corticosteroids are recommended as fi rst-line therapy for patients with moderate-to-severe disease, especially when nasal congestion is a major component of symptoms. To compare the effi cacy and safety profi le of different available intranasal corticosteroids for the treatment of AR, it is important to understand their different structures and pharmacokinetic and pharmacodynamic properties. Knowledge of these drugs has increased tremendously over the last decade. Studies have elucidated mechanisms of action, pharmacologic properties, and the clinical impact of these drugs in allergic respiratory diseases. Although the existing intranasal corticosteroids are already highly effi cient, the introduction of further improved formulations with a better effi cacy/ safety profi le is always desired. Fluticasone furoate nasal spray is a new topical corticosteroid, with enhanced-affi nity and a unique side-actuated delivery device. As it has high topical potency and low potential for systemic effects, it is a good candidate for rhinitis treatment.

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“…Although current literature suggests that the use of intranasal steroids is quite safe. [8][9][10] In our study, VAS score was improved significantly in fluticasone group as compared to isotonic saline group on day 15 and day 30. Fluticasone treatment group showed a greater numerical decrease in nasal symptoms in most of the individuals as compared to isotonic saline group.…”

Section: Discussionmentioning

confidence: 47%

Isotonic nasal spray versus fluticasone nasal spray in treatment of allergic rhinitis

Gaddipatti¹,

Rao²,

Rajiv³

et al. 2017

Int J Otorhinolaryngol Head Neck Surg

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Background: Allergic rhinitis (AR) is a prevalent disease with great morbidity and causing signiﬁcant societal and economic burden. Aims and objectives: To compare efficacy of fluticasone nasal spray and isotonic saline nasal spray in allergic rhinitis.Methods: This was a prospective randomized study conducted on patients of allergic rhinitis coming to ENT OPD a tertiary care teaching hospital. Sixty patients diagnosed with concomitant diagnosis of allergic rhinitis was randomly allocated to either Fluticasone propionate nasal spray (n= 30) and isotonic saline spray (n= 30). Results: The most common age group in fluticasone group was 21 to 30 years while in isotonic saline group 31 to 40 years was the most common age group. There was 52.8% of female and 47.2% in fluticasone group while in isotonic saline group, 52.5% of study population were female and 47.5% were male. There was significant improvement in VAS on day 15 and day 30 as compared to day 1 in fluticasone treated subjects as compared to isotonic saline group. After one month, Nasal blockage, nasal discharge, sneezing, nasal itching was improved to 71%, 69%, 81% and 78% in fluticasone treated subjects as compared to isotonic saline group in which improvement was up to 11%, 17%, 09% and 12% respectively and this difference was statistically significant. Conclusions: Fluticasone nasal spray has the potential to enhance patient satisfaction and compliance and reduce the need for polypharmacy in the management of seasonal allergic rhinitis.

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Effect of topical nasal steroid sprays on nasal mucosa and ciliary function

Cited by 23 publications

References 25 publications

The Effect of Topical Corticosteroids, Topical Antihistamines, and Preservatives on Human Ciliary Beat Frequency

The Effect of Topical Corticosteroids, Topical Antihistamines, and Preservatives on Human Ciliary Beat Frequency

Fluticasone furoate nasal spray in the treatment of allergic rhinitis

Isotonic nasal spray versus fluticasone nasal spray in treatment of allergic rhinitis

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