Effect of Topical Mitomycin C on Corneal Endothelium

Mitomycin C–Assisted Photorefractive Keratectomy in High Myopia: A Long-term Safety Study

“…2,7,[26][27][28][29] Moreover, a concentration of MMC substantially greater than that used in refractive surgery, applied in a cyclic manner for the treatment of ocular surface squamous tumors, does not significantly affect the corneal endothelium. 30 In the current study, the loss of endothelial cells 5 years after surgery was not statistically significant and is consistent with the physiologic decrease in corneal endothelial cells. 31 The subbasal nerve plexus is ablated during PRK, and the recovery of nerve fibers is a slow process.…”

Photorefractive keratectomy with mitomycin-C after corneal transplantation for keratoconus

“…60,61 Although a growing number of studies confirm the judicious use of MMC as safe in terms of possible complications, they must be taken into account when weighing the relative merits of PRK against those of other techniques. [62][63][64][65][66] Barreto et al 67 recently described positive results in a case of a topography-guided ablation with MMC after PKP for keratoconus. The ability to correct irregular astigmatism is a limiting factor in achieving the best results in the post-PKP eye.…”

Topical chemotherapy for ocular surface squamous neoplasia

“…Furthermore, the use of plugs has not been found to change the rate of resolution of disease and may increase ocular surface and surrounding skin toxicity with spillover of the medication [27]. No patients in the reviewed literature of treatment for OSSN developed systemic side-effects, scleral or corneal melts, endothelial changes, or iridocyclitis, although some of these side-effects have occurred after pterygium surgery and after photorefractive keratectomy with MMC [38][39][40].…”