Effect of topical dexamethasone and ciprofloxacin on bacterial flora of healthy conjunctiva

Ermiş, Sıtkı Samet; Aktepe, Orhan Cem; İnan, Ümit Übeyt; Öztürk, Faruk; Altındiş, Mustafa

doi:10.1038/sj.eye.6700631

Cited by 20 publications

(14 citation statements)

References 11 publications

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“…The change in ocular flora due to chronic use of topical steroids in keratoconus patients with VKC can lead to an increased risk of postoperative keratitis [24]. Hence, while using ACXL to treat children, we recommend the usage of a limbal guard to protect the LSCs from damage and stoppage of the use of topical steroids (once the VKC is controlled) for at least two weeks prior to the procedure.…”

Section: Discussionmentioning

confidence: 99%

Accelerated Corneal Collagen Cross-Linking in Pediatric Patients: Two-Year Follow-Up Results

Shetty

Nagaraja

Jayadev

et al. 2014

BioMed Research International

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Purpose. To evaluate the effectiveness and safety of accelerated corneal collagen cross-linking (ACXL) in patients below 14 years of age with progressive keratoconus. Materials and Methods. Thirty eyes of 18 patients with established progressive keratoconus underwent preoperative and postoperative visual acuity assessment, topography, and specular microscopy prior to ACXL and were followed up for 24 months. Results. Mean age of the patients was 12.7 years with ten males and eight females. There was an improvement in the mean postoperative uncorrected distant visual acuity (from 0.76 ± 0.26 to 0.61 ± 0.25; P = 0.005), mean corrected distant visual acuity (from 0.24 ± 0.19 to 0.12 ± 0.12; P < 0.001), mean spherical refraction (from −3.04 DS ± 3.60 to −2.38 DS ± 3.37; P = 0.28), mean cylinder (from −3.63 DC ± 1.82 to −2.80 DC ± 1.48; P = 0.008), and spherical equivalent (from −4.70 D ± 3.86 to −3.75 D ± 3.49; P = 0.15). Three eyes of two patients with vernal keratoconjunctivitis (VKC) showed progression. There were no intra- or postoperative complications. Conclusion. In pediatric patients ACXL is an effective and safe procedure for the management of keratoconus. Optimal management of VKC is important to arrest the progression of keratoconus.

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Section: Discussionmentioning

confidence: 99%

Accelerated Corneal Collagen Cross-Linking in Pediatric Patients: Two-Year Follow-Up Results

Shetty

Nagaraja

Jayadev

et al. 2014

BioMed Research International

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“…41,42 Antibacterial honeys also seem to stimulate monocytes in cell culture to release cytokines, tumor necrosis factor-a, interleukin-1, and interleukin-6, which activate the immune response to infection. 43 Both topical and systemic antibiotics can significantly reduce the CFUs in normal eyes 26,44 and in eyes with chronic lid disease, 24 but these effects are only short term, and the CFUs eventually return to pretreatment levels. 44 Dry eye conditions such as tear deficiency and meibomian gland disease are chronic conditions for which there is no cure.…”

Section: Discussionmentioning

confidence: 99%

“…43 Both topical and systemic antibiotics can significantly reduce the CFUs in normal eyes 26,44 and in eyes with chronic lid disease, 24 but these effects are only short term, and the CFUs eventually return to pretreatment levels. 44 Dry eye conditions such as tear deficiency and meibomian gland disease are chronic conditions for which there is no cure. Repeated dosing with topical or systemic antibiotics to control lid bacteria is expected to create resistance problems, and there are additional side effects to consider with repeated or long-term antibiotic dosing such as ocular surface toxicity with topical antibiotics and systemic side effects of oral agents.…”

Section: Discussionmentioning

confidence: 99%

Effect of Antibacterial Honey on the Ocular Flora in Tear Deficiency and Meibomian Gland Disease

Albietz¹,

Lenton²

2006

Cornea

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“…Subgroup analysis demonstrates this is an independent risk factor and other potential confounding factors are not responsible (such as recent surgery or uveitis which are common causes for necessitating preoperative topical steroids). Topical steroids in the short term do not increase conjunctival bacterial flora counts,25 but topical steroids do reduce the function of leucocytes to oppose infection so we speculate that preoperative topical steroids may locally immunocompromise the eye and hence increase the risk of endophthalmitis.…”

Section: Discussionmentioning

confidence: 84%

A prospective and nationwide study investigating endophthalmitis following pars plana vitrectomy: incidence and risk factors

et al. 2014

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Background/aims This is the first nationwide prospective study to investigate the incidence and risk factors of endophthalmitis following pars plana vitrectomy (PPV). Methods This was a prospective, nationwide casecontrol study. Cases of presumed infectious endophthalmitis within 6 weeks of PPV were reported via the established British Ophthalmological Surveillance Unit. The surveillance period was 2 years. Controls (patients who had PPV but no endophthalmitis) were recruited from nine randomly selected UK centres. Results 37 reports were received and 28 cases met the diagnostic criteria for presumed infectious endophthalmitis following PPV. The incidence of endophthalmitis following PPV was 28 cases per 48 433 PPVs (1 in 1730 with a 95% CI of 1 in 1263 to 1 in 2747). 272 controls were randomly recruited from nine UK centres. Smaller gauge port sizes were not found to be a risk. Immunosuppression (OR 19.0, p=0.001) and preoperative topical steroids (OR 131.4, p<0.001) increased the endophthalmitis risk. Operating for retinal detachment was associated with a reduced risk of endophthalmitis (OR 0.10, p=0.005). Conclusions Endophthalmitis following PPV is rare. Operating with smaller gauge port sizes does not increase the risk of endophthalmitis.

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Effect of topical dexamethasone and ciprofloxacin on bacterial flora of healthy conjunctiva

Cited by 20 publications

References 11 publications

Accelerated Corneal Collagen Cross-Linking in Pediatric Patients: Two-Year Follow-Up Results

Accelerated Corneal Collagen Cross-Linking in Pediatric Patients: Two-Year Follow-Up Results

Effect of Antibacterial Honey on the Ocular Flora in Tear Deficiency and Meibomian Gland Disease

A prospective and nationwide study investigating endophthalmitis following pars plana vitrectomy: incidence and risk factors

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