Effect of topical application of fipronil in cats with flea allergic dermatitis

Medleau, Linda; Hnilica, Keith A.; K, Lower; Alva, Roberto; Clekis, T.; Case, Jerry; McArthur, T Reid; Barrick, R A; Jeannin, Philippe; Irwin, Jennifer

doi:10.2460/javma.2002.221.254

Cited by 15 publications

(13 citation statements)

References 6 publications

(1 reference statement)

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“…Cats included in the present study were not skin-tested with flea allergens. Intradermal injection of flea antigens or serological tests was used to diagnose FAD in dogs [ 9 – 11 ] and cats [ 12 ]. However, positive immediate intradermal reactivity to flea antigens is possible in normal dogs.…”

Section: Discussionmentioning

confidence: 99%

“…Several different insecticides (or combinations of insecticides) were shown to be useful for the control the clinical signs of AD, including FAD in cats, but there are only a few studies about the control of clinical signs in naturally infested cats [ 12 , 17 , 20 – 22 ]. For an efficient control of flea allergy, two major characteristics are required: (i) a rapid adulticide activity; and (ii) a long duration of action.…”

Section: Discussionmentioning

confidence: 99%

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Usefulness of a topical combination of dinotefuran and pyriproxyfen for long-term control of clinical signs of allergic dermatitis in privately-owned cats in Ile-de-France region

Crosaz

Bonati²,

Briand

et al. 2017

Parasites Vectors

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BackgroundThe present study assessed the activity of a combination of dinotefuran and pyriproxyfen (Vectra® Felis) for long-term control (3 months) of allergic dermatitis (AD) in privately-owned cats under common household conditions in Ile-de-France region.MethodsThis was an open pre-treatment vs post-treatment study. Twenty-eight client-owned cats with clinical signs of AD were enrolled in the study. They received topical application of the combination of dinotefuran and pyriproxyfen on days 0, 28, 56 and 84. Two parameters (clinical signs and pruritus severity) were used to assess the animals’ condition on days 0, 28 and 84. Fleas were counted if they were observed.ResultsOf the 28 cats initially enrolled, 26 were presented on day 28 and 20 for the final evaluation on day 84. A significant improvement in clinical signs and pruritus was observed in cats for which fleas and/or flea feces were detected on day 0. Globally, the post-treatment AD clinical scores on days 28 and 84 were different from that of the pre-treatment on day 0, with a reduction of 30% and 71%, respectively. For cats with fleas and/or flea feces, the reduction on days 28 and 84 was 33% and 85%, respectively. The improvement of clinical signs and pruritus was not significant in cats with no visible fleas and no flea feces at the beginning of the trial (n = 8).ConclusionsThe present study indicated that the treatment with a combination of dinotefuran and pyriproxyfen should be considered as useful in controlling fleas on cats without additional environmental treatment and useful for long-term control of clinical signs and pruritus in allergic cats.Electronic supplementary materialThe online version of this article (doi:10.1186/s13071-017-2335-x) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Usefulness of a topical combination of dinotefuran and pyriproxyfen for long-term control of clinical signs of allergic dermatitis in privately-owned cats in Ile-de-France region

Crosaz

Bonati²,

Briand

et al. 2017

Parasites Vectors

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“…1B) is used either as a veterinary medicine (Medleau et al, 2002) or as an agricultural pesticide. It is effective against numerous terrestrial insects, e.g.…”

Section: Introductionmentioning

confidence: 99%

Transient alterations in neuronal and behavioral activity following bensultap and fipronil treatment in rats

et al. 2005

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“…Comparando-se estatisticamente as médias de pulgas vivas do grupo tratado com a formulação teste e a formulação referência de fipronil não houve diferença (P > 0,05) durante todo o período experimental, caracterizando proteção contra reinfestações para ambas. Medleau et al (2002) empregaram três tratamentos com intervalos mensais em gatos e obtiveram eficácia de 75, 73, 85 e 94% nos dias +14, +30, +60 e +90, respectivamente. No entanto, podem ser confrontados os resultados obtidos para o dia +14, pois até tais períodos observacionais, as metodologias empregadas foram equivalentes.…”

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“…No entanto, podem ser confrontados os resultados obtidos para o dia +14, pois até tais períodos observacionais, as metodologias empregadas foram equivalentes. Portanto, pode-se afirmar que, tanto para formulação teste de fipronil quanto para a de referência, as eficácias obtidas neste estudo foram superiores às obtidas pelo estudo de Medleau et al (2002). Para a comparação da eficácia obtida por Medleau et al (2002) no dia +30, pode-se confrontá-la com os índices de eficácia alcançados nos dias +28 e +35 do presente estudo, 95,1% e 86,6%, respectivamente, para formulação teste, e 89,6% e 74,6% para a de referência, que ainda se apresentaram superiores.…”

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Eficácia comparativa de duas formulaÇões de uso tópico contendo fipronil 10ĳ no controle de Ctenocephalides felis felis em gatos

Tancredi¹,

Correia²,

Ribeiro³

et al. 2009

RBPV

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The goal of the present study was to evaluate the comparative efficacy of two topical formulations containing 10% fipronil on the control of Ctenocephalides felis felis on cats. The trial was performed at the Laboratory of Experimental Chemotherapy in Veterinary Parasitology from the Department of Animal Parasitology of the Institute of Veterinary of the Universidade Federal Rural do Rio de Janeiro. Eighteen mixed-breed cats were divided in three groups of six animals each. One group remained without treatment (control). The other groups received as treatment the two topical formulations, a commercial reference and the novel one, both containing 10% fipronil. Treated animals received 0.5 mL of product along their cervical region. Cats were infested on days - 2, +5, +12, +19, +26 and +33. Evaluations were made using the "comb test". The first one was undertaken 4 days after the initial infestation (day +2), and others 48 hours after following infestations (days +7, +14, +21, +28 and + 35). Both tested formulations had satisfactory efficacy until day + 35. No differences were observed comparing the efficacy levels between both formulations throughout the experimental period. The novel topical 10% fipronil formulation presented desirable efficacy on the control of C. f. felis on cats.

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Effect of topical application of fipronil in cats with flea allergic dermatitis

Abstract: Results suggest that monthly topical application of fipronil is effective for treatment of flea allergic dermatitis in cats housed under natural conditions.

Cited by 15 publications

References 6 publications

Usefulness of a topical combination of dinotefuran and pyriproxyfen for long-term control of clinical signs of allergic dermatitis in privately-owned cats in Ile-de-France region

Usefulness of a topical combination of dinotefuran and pyriproxyfen for long-term control of clinical signs of allergic dermatitis in privately-owned cats in Ile-de-France region

Transient alterations in neuronal and behavioral activity following bensultap and fipronil treatment in rats

Eficácia comparativa de duas formulaÇões de uso tópico contendo fipronil 10ĳ no controle de Ctenocephalides felis felis em gatos

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