2018
DOI: 10.1111/vop.12604
|View full text |Cite
|
Sign up to set email alerts
|

Effect of topical application of 0.5% proparacaine on corneal culture results from 33 dogs, 12 cats, and 19 horses with spontaneously arising ulcerative keratitis

Abstract: Proparacaine did not significantly alter bacterial or fungal culture results in cats, dogs, or horses; however, clinical significance warrants investigation. Culture and cytology provided complementary data; both should be performed to maximize organism detection in patients with ulcerative keratitis.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

1
7
1

Year Published

2019
2019
2023
2023

Publication Types

Select...
6
2
1

Relationship

0
9

Authors

Journals

citations
Cited by 15 publications
(9 citation statements)
references
References 10 publications
1
7
1
Order By: Relevance
“…23 Similarly, while a study performed with human subjects demonstrated a 75% reduction in culturepositive samples following the application of proparacaine, 9 two studies with animal subjects reported no significant difference in culture results for ulcerative keratitis following the application of proparacaine. 8,24 Our results concur with these F I G U R E 3 Unique bacterial species reduction between paired swabs based on treatment group. Unique bacterial species isolated from swab #1 (before), but absent from swab #2 isolates (after) as a total number by treatment group.…”
Section: Discussionsupporting
confidence: 87%
“…23 Similarly, while a study performed with human subjects demonstrated a 75% reduction in culturepositive samples following the application of proparacaine, 9 two studies with animal subjects reported no significant difference in culture results for ulcerative keratitis following the application of proparacaine. 8,24 Our results concur with these F I G U R E 3 Unique bacterial species reduction between paired swabs based on treatment group. Unique bacterial species isolated from swab #1 (before), but absent from swab #2 isolates (after) as a total number by treatment group.…”
Section: Discussionsupporting
confidence: 87%
“…Finally, all samples for bacterial culture were collected after the topical application of tetracaine. Edwards et al 31 has studied the effect of topical tetracaine on corneal culture in 19 horses with ulcerative keratitis and concluded that topical anesthetic did not significantly alter bacterial culture results in horses.…”
Section: Discussionmentioning
confidence: 99%
“…Proparacaine has been shown to inhibit Staphylococcus aureus, but not P. aeruginosa growth in vitro [40]. However, a veterinary study demonstrated no significant effect of proparacaine on the number of bacteria isolated from ocular surface samples, suggesting that proparacaine did not impact this study [41]. Similarly, previous studies have demonstrated rapid clearance of P. aeruginosa on the ocular surface of rodents [42], suggesting that the rapid reduction of pathogen bacteria on the ocular surface was due to the innate immune system of the eye rather than due to swabbing the ocular surface.…”
Section: Discussionmentioning
confidence: 79%