Effect of topical application of mitomycin-C on wound healing in a postlaminectomy rat model: An experimental study

The role of hybrid chitosan membranes on scarring process following lumbar surgery: post-laminectomy experimental model

“…This process can progress to the vertebral canal and create adherences to the duramater and nerve roots and inflammation is considered to play an important and early role in this process. [18][19][20] Fibroblasts have multiple functions important to wound repair, such as collagen synthesis, extracellular matrix reorganization, and wound contraction resulting in mature scar formation. It has been shown that chitosan can inhibit fibroblast growth.21,22 Chang et al in a study for reduction of peritoneal adhesions concluded that a chitosan barrier can inhibit tissue adhesion by inhibiting proliferation and triggering apoptosis.22 For this study it was used an animal laminectomy model using New Zealand rabbits.…”

An experimental novel study: hyperbaric oxygen treatment on reduction of epidural fibrosis via down-regulation of collagen deposition, IL-6, and TGF-β1

“…The density of capillary was assessed as previous study reported [17]. The numbers of blood vessels with a visible lumen was counted in each of these areas at 4009 magnification.…”

Effects of Pirfenidone and Collagen-Polyvinylpyrrolidone on Macroscopic and Microscopic Changes, TGF-β1 Expression, and Collagen Deposition in an Experimental Model of Tracheal Wound Healing

“…Conversely, group III likely exhibited few blood vessels because MMC blocks vascular endothelial growth factor (VEGF) expression, as described by Su et al who studied the effect of this compound on wound healing after a laminectomy [34]. …”