Effect of toluene on fathead minnow (Pimephales promelas Rafinesque) development

Devlin, E. W.; Brammer, J. D.; Puyear, Robert L.

doi:10.1007/bf01055390

Cited by 17 publications

(11 citation statements)

References 31 publications

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“…Although these results do not provide the resolution necessary to determine the specific time at which FET tests should be terminated, Belanger et al showed that at 25 °C the large majority of 24 h to 48 h posthatch zebrafish exhibited independent feeding, indicating that FET tests in this species should be terminated in this time frame. For fathead minnows, Devlin et al showed that at 25 °C larvae absorb their yolk sacs at approximately 32 h posthatch and feed independently at approximately 57 h posthatch, suggesting that fathead minnow FET tests should be terminated prior to 32 h to 57 h posthatch.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, the fathead minnow FET tests featured embryos at the 32‐cell stage or less and the majority of embryos used were at the 16‐cell to 32‐cell stage. Previous studies have shown that the chorion of fathead minnow embryos is water‐hardened by the 32‐cell stage ; therefore, it is possible that fathead minnow embryos exposed to DCA were already water‐hardened on exposure initiation and, as a result, were less sensitive to DCA than their zebrafish counterparts. Additionally, the fathead minnow chorion is thicker and has narrower pores than that of the zebrafish , suggesting that fathead minnow eggs may be generally less permeable than zebrafish eggs.…”

Section: Discussionmentioning

confidence: 99%

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Alternative methods for toxicity assessments in fish: Comparison of the fish embryo toxicity and the larval growth and survival tests in zebrafish and fathead minnows

Jeffries

Stultz

Smith

et al. 2014

Enviro Toxic and Chemistry

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An increased demand for chemical toxicity evaluations has resulted in the need for alternative testing strategies that address animal welfare concerns. The fish embryo toxicity (FET) test developed for zebrafish (Danio rerio) is one such alternative, and the application of the FET test to other species such as the fathead minnow (Pimephales promelas) has been proposed. In the present study, the performances of the FET test and the larval growth and survival (LGS; a standard toxicity testing method) test in zebrafish and fathead minnows were evaluated. This required that testing methods for the fathead minnow FET and zebrafish LGS tests be harmonized with existing test methods and that the performance of these testing strategies be evaluated by comparing the median lethal concentrations of 2 reference toxicants, 3,4-dicholoraniline and ammonia, obtained via each of the test types. The results showed that procedures for the zebrafish FET test can be adapted and applied to the fathead minnow. Differences in test sensitivity were observed for 3,4-dicholoraniline but not ammonia; therefore, conclusions regarding which test types offer the least or most sensitivity could not be made. Overall, these results show that the fathead minnow FET test has potential as an alternative toxicity testing strategy and that further analysis with other toxicants is warranted in an effort to better characterize the sensitivity and feasibility of this testing strategy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Alternative methods for toxicity assessments in fish: Comparison of the fish embryo toxicity and the larval growth and survival tests in zebrafish and fathead minnows

Jeffries

Stultz

Smith

et al. 2014

Enviro Toxic and Chemistry

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“…In total 100 to 400 eggs ranging from developmental stage 8 (32-celled blastodisc) to developmental stage 12 (early gastrula) [27] were collected from each spawning substrate and pooled. To verify fertilization and stage, 50 fertilized eggs from the pooled sample were evaluated microscopically and then divided into egg cups.…”

Section: Twenty-one-day Reproduction Studymentioning

confidence: 99%

Effects of a glucocorticoid receptor agonist, dexamethasone, on fathead minnow reproduction, growth, and development

LaLone

Villeneuve

Olmstead

et al. 2012

Enviro Toxic and Chemistry

100

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Synthetic glucocorticoids are pharmaceutical compounds prescribed in human and veterinary medicine as anti-inflammatory agents and have the potential to contaminate natural watersheds via inputs from wastewater treatment facilities and confined animal-feeding operations. Despite this, few studies have examined the effects of this class of chemicals on aquatic vertebrates. To generate data to assess potential risk to the aquatic environment, we used fathead minnow 21-d reproduction and 29-d embryo-larvae assays to determine reproductive toxicity and early-life-stage effects of dexamethasone. Exposure to 500 µg dexamethasone/L in the 21-d test caused reductions in fathead minnow fecundity and female plasma estradiol concentrations and increased the occurrence of abnormally hatched fry. Female fish exposed to 500 µg dexamethasone/L also displayed a significant increase in plasma vitellogenin protein levels, possibly because of decreased spawning. A decrease in vitellogenin messenger ribonucleic acid (mRNA) expression in liver tissue from females exposed to the high dexamethasone concentration lends support to this hypothesis. Histological results indicate that a 29-d embryo-larval exposure to 500 µg dexamethasone/L caused a significant increase in deformed gill opercula. Fry exposed to 500 µg dexamethasone/L for 29 d also exhibited a significant reduction in weight and length compared with control fry. Taken together, these results indicate that nonlethal concentrations of a model glucocorticoid receptor agonist can impair fish reproduction, growth, and development.

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“…promelas embryos irradiated between 12 and 24 dpf (three-quarter epiboly to 18-20 somite pairs (Devlin et al, 1996) -Taguchi, 1983), and D. rerio (Yabu et al, 2001), I found that A. limnaeus embryos irradiated at 4 dpf tended to have higher LD50 values for both recovery treatments (Figure 2.14). Interestingly, the 1,000 cell stage of the zebrafish may be the most resistant embryonic stage to death and malformation due to UV radiation induced DNA damage (Dong et al, 2007).…”

Section: Embryos Of a Limnaeus Have A Competent Cpd Photorepair Systemmentioning

confidence: 91%

Developmental Mechanisms that Support Genome Stability and Embryonic Survival in Stress-tolerant Embryos of the Annual Killifish <i>Austrofundulus limnaeus</i>

Wagner¹

2000

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In order to complete their life cycles, vertebrates require oxygen and water. However, environments are not always forgiving when it comes to constantly providing these basic needs for vertebrate life. The annual killifish Austrofundulus limnaeus is possibly the most well described extremophile vertebrate and its embryos have been shown to tolerate extremes in oxygen, salinity, and water availability. This phenotype is likely a result of the annual killifish life history, which includes periods of temporary habitat desiccation and oxygen deprivation, and requires the production of stress-tolerant embryos that depress metabolism in a state of suspended animation, known as diapause. Over the past several decades, the basic morphology and physiology of annual killifish development has become better characterized. However, there are still basic cellular processes that remain to be described in annual killifish such as A. limnaeus. Specifically, changes in DNA structure, expression, and copy number are known to have profound impacts on the phenotype and survival of an organism. Little is known as to how A. limnaeus maintains genome integrity during cell stress, nor how the A. limnaeus nuclear and mitochondrial genomes may have evolved under the unpredictable conditions in which A. limnaeus thrive. Early annual killifish embryonic development is also characterized by a complete dispersion and subsequent reaggregation of embryonic blastomeres prior to formation of the embryonic axis. This unusual period of v ACKNOWLEDGEMENTS My completion of this dissertation required support from many people. I would like to thank my mentor and advisor Jason Podrabsky for his never-ending support and invaluable insight throughout my entire graduate experience. This document and the scientific publications derived from it would not exist without his expertise and belief in my ability to succeed. I thank my graduate committee: Suzanne Estes, Justin Courcelle, Deborah Lutterschmidt, and Gwen Shusterman for taking the time and effort to ensure my research, and myself as a scientist, could reach my potential. I thank Charmain Courcelle and Kim Brown for their advice and for allowing me to use their lab equipment. I am appreciative of the support of my colleagues,

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Effect of toluene on fathead minnow (Pimephales promelas Rafinesque) development

Cited by 17 publications

References 31 publications

Alternative methods for toxicity assessments in fish: Comparison of the fish embryo toxicity and the larval growth and survival tests in zebrafish and fathead minnows

Alternative methods for toxicity assessments in fish: Comparison of the fish embryo toxicity and the larval growth and survival tests in zebrafish and fathead minnows

Effects of a glucocorticoid receptor agonist, dexamethasone, on fathead minnow reproduction, growth, and development

Developmental Mechanisms that Support Genome Stability and Embryonic Survival in Stress-tolerant Embryos of the Annual Killifish <i>Austrofundulus limnaeus</i>

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