Effect of Tolbutamide (Orinase) on Plasma Non-Esterified Fatty Acids

Bierman, Edwin L.; Roberts, Thomas N; Dole, Vincent P.

doi:10.3181/00379727-95-23244

Cited by 20 publications

(2 citation statements)

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“…The changes in the concentration of blood glucose and plasma FFA after intravenous tolbutamide are similar to those observed by Bierman et al 11 These responses differed considerably, however, from those we observed after the sulfonylureas were taken by mouth. After oral administration, neither the fall nor the rise in the FFA levels paralleled the change in the concentration of blood glucose.…”

Section: Discussionsupporting

confidence: 77%

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Effect of Sulfonylurea Drugs on Plasma Free Fatty Acid and Blood Glucose Concentrations in Man

Stone

Brown

1966

Diabetes

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We have studied the effect of sulfonylurea drugs on plasma free fatty acid and blood glucose concentrations in man. The concentrations of plasma free fatty acids and blood glucose were measured after the oral administration of a single dose of sulfonylurea drugs to fasting, maturityonset, ketoacidosis-resistant diabetic patients. The changes in concentration of glucose and free fatty acids were not parallel as they are after systemic insulin or intravenous tolbutamide. There was no significant decrease in glucose concentration during the first hour after oral administration and little decrease at the second hour, but then a decrease to a minimum at five to six hours. During the first two hours, however, the concentration of free fatty acids decreased significantly despite little change in glucose concentration. At two hours, the concentration of free fatty acids decreased to its minimum, despite the fact that glucose concentration continued to decrease until five or six hours. These results are consistent with our earlier in vitro data and with the interpretation that the sulfonylurea drugs may have a direct antilipolytic effect. DIABETES J5: 314-18, May, 1966.

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Section: Discussionsupporting

confidence: 77%

“…These data confirm those of Bierman, Roberts and Dole. 11 One patient received intravenous acetohexamide. The data paralleled those with intravenous tolbutamide.…”

Section: Intravenous Sulfonylureamentioning

confidence: 99%