Effect of TNF-a on Human Ovarian Cancer Xenografts in Nude Mice

Effects of Inflammatory Factors on Mesenchymal Stem Cells and Their Role in the Promotion of Tumor Angiogenesis in Colon Cancer

“…IFN-␥ and TNF-␣ are important inflammatory cytokines. The role of TNF-␣ in driving tumor progression has been emphasized by Balkwill and co-workers (21). Their work provides an example of how tumors usurp the normal process of inflammation to promote their own progression.…”

Lithium Sensitizes Tumor Cells in an NF-κB-independent Way to Caspase Activation and Apoptosis Induced by Tumor Necrosis Factor (TNF)

“…However, combination treatments that allow the use of lower nontoxic TNF doses might still offer opportunities for TNF in the treatment of cancer. Combination treatments have already proven their success in the clinic, as demonstrated by isolated limb perfusion of melanoma and carcinoma patients (5,6). However, a systemic treatment is still hampered by toxic side effects.…”

Schedule-Dependent Toxicity of Tumor Necrosis Factor in Rodents

“…LDH content in the media increases over the first [18][19][20] hrs in both control and treated groups due to the death of marginally intact cells which were not removed after the initial washing. Thus LDH leakage reached a plateau and remained constant in the controls since only viable cells were present.…”

“…DISCUSSION TNF-a has been shown to produce reproducible cytotoxic effects on tumor cells in vivo (19) and in vitro (20).…”