Effect of titanium dioxide nanoparticles on the cardiovascular system after oral administration

Chen, Zhangjian; Wang, Yun; Zhuo, Lin; Chen, Shi; Zhao, Lin; Luan, Xianguo; Wang, Haifang

doi:10.1016/j.toxlet.2015.09.013

Cited by 101 publications

(76 citation statements)

References 42 publications

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“…The studies applying the longest exposure of all studies with characterized and uncoated TiO 2 NPs, were those of Chen et al (2015), Wang et al (2013) and the 28-d study in Warheit et al (2015a). Chen et al (2015) focused on cardiac toxicity and inflammatory response in initially young rats (3 weeks old at the start of the study) after 30 and 90 days of exposure.…”

Section: Kinetic Modelmentioning

confidence: 99%

“…Chen et al (2015) focused on cardiac toxicity and inflammatory response in initially young rats (3 weeks old at the start of the study) after 30 and 90 days of exposure. They report decreases of lactate dehydrogenase (LDH), hydroxybutyrate dehydrogenase (HBDH), and triglycerides and increase of white blood cells and granulocytes at 50 mg/kg bw/d after 90 days.…”

Section: Kinetic Modelmentioning

confidence: 99%

“…The observed increase in TBIL in the study of Wang et al (2013) supports the other signs of liver damage and could also match the hyperplasia of bile ducts seen in the NCI study (1979) at 1250 mg/kg bw/d and higher. The study of Chen et al (2015), evaluating the effects of TiO 2 NPs on the cardiovascular system after oral administration, was not used in the risk assessment, because the distribution to the liver is4500-fold higher than the distribution to the heart (Geraets et al, 2014), and the NOAELs of Chen et al (2015) and Wang et al (2013) were comparable. Shukla et al (2014) detected liver effects in adult mice at lower doses than in the adult rats of Wang et al (2013), after 14 days of exposure.…”

Section: Kinetic Modelmentioning

confidence: 99%

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Risk assessment of titanium dioxide nanoparticles via oral exposure, including toxicokinetic considerations

et al. 2016

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Titanium dioxide white pigment consists of particles of various sizes, from which a fraction is in the nano range (5100 nm). It is applied in food as additive E 171 as well as in other products, such as food supplements and toothpaste. Here, we assessed whether a human health risk can be expected from oral ingestion of these titanium dioxide nanoparticles (TiO 2 NPs), based on currently available information. Human health risks were assessed using two different approaches: Approach 1, based on intake, i.e. external doses, and Approach 2, based on internal organ concentrations using a kinetic model in order to account for accumulation over time (the preferred approach). Results showed that with Approach 1, a human health risk is not expected for effects in liver and spleen, but a human health risk cannot be excluded for effects on the ovaries. When based on organ concentrations by including the toxicokinetics of TiO 2 NPs (Approach 2), a potential risk for liver, ovaries and testes is found. This difference between the two approaches shows the importance of including toxicokinetic information. The currently estimated risk can be influenced by factors such as absorption, form of TiO 2 , particle fraction, particle size and physico-chemical properties in relation to toxicity, among others. Analysis of actual particle concentrations in human organs, as well as organ concentrations and effects in liver and the reproductive system after chronic exposure to well-characterized TiO 2 (NPs) in animals are recommended to refine this assessment.

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Section: Kinetic Modelmentioning

confidence: 99%

Section: Kinetic Modelmentioning

confidence: 99%

Section: Kinetic Modelmentioning

confidence: 99%

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Risk assessment of titanium dioxide nanoparticles via oral exposure, including toxicokinetic considerations

et al. 2016

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“…However, the inflammatory response in subjects returned to control levels a few days' post exposure (Grassian et al, 2007). After performing an in vivo study in rats investigating the effects of daily oral and gastrointestinal administration of titanium dioxide nanoparticles over the span of 30 to 90 days, Chen et al found significant cardio vascular damage and inflammatory response (Chen et al, 2015).…”

Section: Toxicitymentioning

confidence: 99%

Titanium Dioxide Nanoparticles in Sunscreens: Properties, Current Regulations, and Potential Effects on Human and Environmental Wellbeing

Yu¹

2017

JSST

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From 2001 to 2010, the incidence rates of melanomas have increased by over 2% for both Canadian men and women. Titanium dioxide nanoparticles are common additives to sunscreen products. Their ability to render creams and lotions transparent, as well as their use as an ultraviolet light filter makes them a popular choice. Yet their effects on the skin, other organs, and the environment are largely unexplored, giving rise to questions about their safety. Current research findings report that titanium dioxide nanoparticles tend to be less hazardous to organisms than other nanomaterials. Nonetheless, studies on test animals and cell cultures show significant neurological, pulmonary, cardiac, and genetic damage once titanium dioxide nanoparticles have been absorbed into the bloodstream through inhalation and ingestion. Nanoparticles are also usually discharged as feces and urine, rinsed off, or disposed of through sewage to enter wastewater treatment plants and released into the surrounding ecosystems. The largest obstacle in nanoparticle research is the lack of consistency in terms of measuring and reporting findings. Since the amounts of nanoparticles present after experiments are often not recorded, it is difficult to quantify the amount of nanoparticles in our environment and the rate at which they are released. In addition, manufacturers often do not label their products accurately, leading to misinformed consumers and the potential for adverse health effects. It is for these reasons that the scientific community, governments, industries, and environmental groups need to collaborate in the interest of public health and environmental sustainability in order set the precedence for future scientific advancements. This review provides background information on the properties of titanium dioxide nanoparticles, the effects of such particles on human and environmental health, the current regulations in place in Europe and North America, as well as suggestions for improving consumer safety.De 2001 à 2010, la fréquence des mélanomes avait augmentée par plus de 2% pour les hommes et les femmes canadiens. Les nanoparticules de dioxyde de titane sont des additifs communs dans des produits de protection anti-UV. Elles sont un choix populaire à cause de leur capacité pour rendre les lotions et les crèmes transparentes, et leur fonction comme un filtre des rayons UV. Pourtant, leurs effets sur la peau, les autres organes et l'environnement sont pour la plupart inexplorés, qui provoque des questions concernant la sécurité de leur utilisation. Les résultats courants nous montrent que les nanoparticules de dioxyde de titane sont souvent moins dangereuses pour les organismes que les autres nanomatériaux. Néanmoins, les recherches sur les animaux de laboratoire et les cultures cellulaires montrent qu'il y a des dommages neurologiques, pulmonaires, cardiaques et génétiques assez signifiants une fois que les nanoparticules de dioxyde de titane sont absorbées par le système sanguin au moyen d'inhalation et ingestion. Les nanop...

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“…[9][10][11][12][13][14] The 2010 American Heart Association scientific statement reached the conclusion that both short-term and chronic exposure to PM 2.5 can trigger cardiovascular disease-related events or increase the risk for cardiovascular mortality, while reductions in PM levels are associated with decreases in cardiovascular mortality. 10 Recent toxicological evaluations of engineered nanoparticles, including nanoparticles of silica 15,16 and titanium dioxide, 17 and carbon nanotube, 18 have demonstrated that exposure to engineered nanoparticles poses risks to cardiovascular functions and causes cardiovascular-related phenotypes in animal models.…”

Section: Introductionmentioning

confidence: 99%

PEG-<em>b</em>-PCL polymeric nano-micelle inhibits vascular angiogenesis by activating p53-dependent apoptosis in zebrafish

Zhou¹,

Dong²,

Shen³

et al. 2016

IJN

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Effect of titanium dioxide nanoparticles on the cardiovascular system after oral administration

Cited by 101 publications

References 42 publications

Risk assessment of titanium dioxide nanoparticles via oral exposure, including toxicokinetic considerations

Risk assessment of titanium dioxide nanoparticles via oral exposure, including toxicokinetic considerations

Titanium Dioxide Nanoparticles in Sunscreens: Properties, Current Regulations, and Potential Effects on Human and Environmental Wellbeing

PEG-<em>b</em>-PCL polymeric nano-micelle inhibits vascular angiogenesis by activating p53-dependent apoptosis in zebrafish

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