Effect of tipepidine with novel antidepressant-like action on c-fos-like protein expression in rat brain

Kawahara, Ryo; Soeda, Fumio; Kawaura, Kazuaki; Honda, Sokichi; Miki, Risa; Noguchi, Tetsuro; Shirasaki, Tetsuya; Takahama, Kazuo

doi:10.1016/j.brainres.2013.03.034

Cited by 11 publications

(7 citation statements)

References 23 publications

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“…Dopamine D 1 receptor stimulation increases the rate of AMPA receptor insertion onto the surface of NAc neurons [33,34]. Further, we previously reported that tipepidine increased the number of c-Fos immunopositive cells in NAc [35]. Taken together, though there is no direct evidence that dopamine released in the NAc activates neurons in the NAc, the present findings further support the hypothesis that tipepidine may produce an antidepressant-like effect via activation of dopamine D 1 receptors in NAc.…”

Section: Discussionsupporting

confidence: 87%

Tipepidine increases dopamine level in the nucleus accumbens without methamphetamine-like behavioral sensitization

Hamao

Kawaura

Soeda

et al. 2015

Behavioural Brain Research

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Section: Discussionsupporting

confidence: 87%

Tipepidine increases dopamine level in the nucleus accumbens without methamphetamine-like behavioral sensitization

Hamao

Kawaura

Soeda

et al. 2015

Behavioural Brain Research

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“…Very recently Kawahara et al24 showed that a single injection of tipepidine (20 mg/kg or 40 mg/kg) in rats, increased FLI-positive neurons in the central nucleus of the amygdala (CeA) in a manner similar to the tested antidepressants, as well as inducing the characteristic increase in FLI-positive neurons in six other brain regions, including the nucleus accumbens (NAcc). This latter effect was not observed with other antidepressants.…”

mentioning

confidence: 99%

Tipepidine in adolescent patients with depression: a 4 week, open-label, preliminary study

Sasaki¹,

Hashimoto²,

Tachibana³

et al. 2014

NDT

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“…Activation of the CeA has also been observed with conventional antidepressants. For instance, acute administration of citalopram and fluoxetine have been reported to increase c-FOS immunoreactivity within the CeA at baseline and in response to the FST ( Miyata et al, 2005 ; Choi et al, 2013 ; Kawahara et al, 2013 ). The ability of antidepressants such as fluoxetine and citalopram to facilitate an increase in neuronal activation within the CeA may relate to pharmacologically induced alterations in 5-HT transmission within the structure.…”

Section: Discussionmentioning

confidence: 99%

Regional Specific Modulation of Stress-Induced Neuronal Activation Associated with the PSD95/NOS Interaction Inhibitor ZL006 in the Wistar Kyoto Rat

Sherwin

Lennon

Harkin

2017

International Journal of Neuropsychopharmacology

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BackgroundTo determine brain areas involved in the antidepressant-related behavioral effects of the selective neuronal nitric oxide synthase inhibitor 1-(2-Trifluoro-methyl-phenyl) imidazole (TRIM) and experimental test compound 4-((3,5-dichloro-2-hydroxybenzyl)amino)-2-hydroxybenzoic acid (ZL006), an inhibitor of the PSD of 95 kDa/neuronal nitric oxide synthase interaction in the N-methyl-D-aspartic acid receptor signalling pathway, regional specific expression of the neuronal activation marker c-FOS was assessed following exposure to the forced swimming test in the Wistar Kyoto rat.MethodsWistar Kyoto rats were subjected to a 15-minute swim pretest (pre-forced swimming test) period on day 1. At 24, 5, and 1 hour prior to the 5-minute test, which took place 24 hours following the pre-forced swimming test, animals were treated with TRIM (50 mg/kg; i.p.), ZL006 (10 mg/kg; i.p.), or saline vehicle (1 mL/kg i.p). Behavior was recorded during both pretest and test periods.ResultsBoth TRIM and ZL006 decreased immobility time in Wistar Kyoto rats in the forced swimming test. Exposure to the forced swimming test increased c-FOS immunoreactivity in the lateral septum, paraventricular nucleus of the hypothalamus, periaqueductal grey, dentate gyrus, and ventral CA1 of the hippocampus compared with non-forced swimming test-exposed controls. Forced swimming test-induced c-FOS immunoreactivity was further increased in the lateral septum, periaqueductal gray, and paraventricular nucleus of the hypothalamus following treatment with TRIM or ZL006. By contrast, forced swimming test-induced c-FOS immunoreactivity was reduced in dorsal dentate gyrus and ventral CA1 following treatment with TRIM or ZL006. Exposure to the forced swimming test resulted in an increase in NADPH diaphorase staining in the paraventricular nucleus of the hypothalamus. This forced swimming test-induced increase was attenuated following treatment with ZL006 and points to the paraventricular nucleus as a brain region where ZL006 acts to attenuate forced swimming test-induced neuronal nitric oxide synthase activity while concomitantly regulating region specific neuronal activation associated with an antidepressant-related response.ConclusionsThis study identified a pattern of enhanced and reduced forced swimming test-related c-FOS immunoreactivity indicative of a regulated network where inhibition of nitric oxide coupled to the N-methyl-D-aspartic acid receptor leads to activation of the lateral septum, periaqueductal gray, and paraventricular nucleus of the hypothalamus with concomitant inhibition of the hippocampus.

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Effect of tipepidine with novel antidepressant-like action on c-fos-like protein expression in rat brain

Cited by 11 publications

References 23 publications

Tipepidine increases dopamine level in the nucleus accumbens without methamphetamine-like behavioral sensitization

Tipepidine increases dopamine level in the nucleus accumbens without methamphetamine-like behavioral sensitization

Tipepidine in adolescent patients with depression: a 4 week, open-label, preliminary study

Regional Specific Modulation of Stress-Induced Neuronal Activation Associated with the PSD95/NOS Interaction Inhibitor ZL006 in the Wistar Kyoto Rat

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