Effect of tincture of Crataegus on the LDL-receptor activity of hepatic plasma membrane of rats fed an atherogenic diet

Rajendran, Shanthi; Deepalakshmi, Putchen Dakshinamoorthy; Parasakthy, K.; Devaraj, Halagowder; Devaraj, S. Niranjali

doi:10.1016/0021-9150(96)05813-3

Cited by 87 publications

(58 citation statements)

References 17 publications

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“…On shaking, they form foam, a property of the S. melongena infusion. Saponins in amounts as low as 150 mg/ kg diet increase the fecal excretion of bile salts in experimental animals and in humans, reducing total cholesterol without affecting the HDL fraction (19)(20)(21). Quantification of saponin concentration and other chemical compounds in the infusion of S. melongena is currently under investigation in our laboratory.…”

Section: Discussionmentioning

confidence: 99%

Eggplant (Solanum melongena) infusion has a modest and transitory effect on hypercholesterolemic subjects

Guimarães

Galvão

Batista

et al. 2000

Braz J Med Biol Res

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Eggplant (Solanum melongena) is consumed extensively in Brazil. It has been believed that infusion of a powdered preparation of the fruit may reduce serum cholesterol. However, there are few documented reports on its effects on cholesterol metabolism and its possible hypocholesterolemic effect has not been proved by well-controlled studies. The aim of the present study was to observe the effects of S. melongena on the serum cholesterol and triglycerides of 38 hypercholesterolemic human volunteers ingesting S. melongena infusion for five weeks. Thirty-eight hypercholesterolemic subjects receiving either S. melongena infusion (N = 19) or placebo (N = 19) participated in two clinical experiments in which the effect of S. melongena infusion was studied with (N = 16) or without (N = 38) dietary orientation. Total cholesterol and its fractions, triglycerides, and apolipoproteins A and B were measured in blood at the beginning of the experiment and three and five weeks thereafter. No differences were observed compared to control. Intraindividual analysis showed that S. melongena infusion significantly reduced the blood levels of total and LDL cholesterol and of apolipoprotein B. After dietary orientation, no intra-or intergroup differences were seen for any of the parameters analyzed. The results suggest that S. melongena infusion had a modest and transitory effect, which was not different from that obtained with standard orientation for dyslipidemia patients (diet and physical activities).

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Section: Discussionmentioning

confidence: 99%

Eggplant (Solanum melongena) infusion has a modest and transitory effect on hypercholesterolemic subjects

Guimarães

Galvão

Batista

et al. 2000

Braz J Med Biol Res

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“…This may be related to enhancement of the LDL-receptor activity. TCR was also shown to increase bile acid excretion and to depress hepatic cholesterol synthesis in atherogenic diet fed rats by upregulating hepatic LDL-receptors resulting in greater influx of plasma cholesterol into the liver [77]. Treatment using hawthorn fruit can decrease serum cholesterol that involves the inhibition of cholesterol absorption mediated by downregulation of intestinal acyl CoA: cholesterol acyltransferase (ACAT) activity in Caco-2 cells.…”

Section: Cardiovascular Effectmentioning

confidence: 99%

Effect ofCrataegusUsage in Cardiovascular Disease Prevention: An Evidence-Based Approach

Wang

Xiong

Feng

2013

Evidence-Based Complementary and Alternative Medicine

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Hawthorn (Crataegus oxyacantha) is a widely used Chinese herb for treatment of gastrointestinal ailments and heart problems and consumed as food. In North America, the role of treatment for heart problems dates back to 1800. Currently, evidence is accumulating from various in vivo and in vitro studies that hawthorn extracts exert a wide range of cardiovascular pharmacological properties, including antioxidant activity, positive inotropic effect, anti-inflammatory effect, anticardiac remodeling effect, antiplatelet aggregation effect, vasodilating effect, endothelial protective effect, reduction of smooth muscle cell migration and proliferation, protective effect against ischemia/reperfusion injury, antiarrhythmic effect, lipid-lowering effect and decrease of arterial blood pressure effect. On the other hand, reviews of placebo-controlled trials have reported both subjective and objective improvement in patients with mild forms of heart failure (NYHA I–III), hypertension, and hyperlipidemia. This paper discussed the underlying pharmacology mechanisms in potential cardioprotective effects and elucidated the clinical applications of Crataegus and its various extracts.

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“…Although the reduction of the TC levels induced by the consumption of hawthorn fruit is a complex process involving multifaceted interactions of cholesterol metabolism, we speculate that the reduction of the cholesterol levels of IDL/LDL was associated with the activation of LDL receptors (LDLR) and LDL receptor-related proteins (LRP). Research has shown that the oral administration of hawthorn extract in rats significantly suppresses the increase in the serum cholesterol levels and upregulates the effects of LDLR on the cell surface 29) . Therefore, increased LDLR activation accelerates the elimination of serum LDL, resulting in lower blood cholesterol.…”

mentioning

confidence: 99%

Hawthorn Fruit Attenuates Atherosclerosis by Improving the Hypolipidemic and Antioxidant Activities in Apolipoprotein E-Deficient Mice

Zhang

Geng

et al. 2014

JAT

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Aims:The protective effects of hawthorn fruit against atherosclerosis and the potential underlying mechanisms of this fruit in improving the hypolipidemic and antioxidant activities were investigated in apolipoprotein E-deficient (apoE −/− ) mice. Methods: ApoE −/− mice were divided into a control group (n = 10) and hawthorn fruit group (n = 10). The mean size of the lesions in the aortic root was assessed, and the serum glucose levels, insulin levels, lipid profiles, total antioxidant capacity (T-AOC) and superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) activities were measured. The mRNA levels of hepatic genes related to lipid metabolism and antioxidant enzymes were examined. Results: The hawthorn fruit group mice developed significantly decreased (p＜0.05) atherosclerotic lesions. The levels of serum lipids decreased significantly (p＜0.05) and the levels of cholesterol/triglycerides, including very-low-density lipoprotein (VLDL) and low-density lipoprotein (LDL), decreased in the hawthorn fruit group. The hawthorn fruit mice exhibited significantly increased T-AOC values and SOD and GSH-PX activities (p＜0.05). The hepatic fatty acid synthase (FAS) and sterol regulatory element binding protein-1c (SREBP-1c) mRNA levels were reduced by 42% (p＜ 0.05) and 23% p＜0.05) in the mice fed the hawthorn fruit diet compared with that observed in the mice fed a standard diet. However, the hepatic hydroxymethylglutaryl CoA reductase (HMG-CoAR) mRNA levels showed no significant differences between the two groups. The mRNA expression levels of the antioxidant enzymes (SOD1, SOD2, Gpx3) were higher (p＜0.05) in the livers of the hawthorn fruit diet mice compared with those observed in the control mice. Conclusions: Hawthorn fruit exerts a protective effect against atherosclerosis in apoE −/− mice by improving the hypolipidemic and antioxidant activities.

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Effect of tincture of Crataegus on the LDL-receptor activity of hepatic plasma membrane of rats fed an atherogenic diet

Cited by 87 publications

References 17 publications

Eggplant (Solanum melongena) infusion has a modest and transitory effect on hypercholesterolemic subjects

Eggplant (Solanum melongena) infusion has a modest and transitory effect on hypercholesterolemic subjects

Effect ofCrataegusUsage in Cardiovascular Disease Prevention: An Evidence-Based Approach

Hawthorn Fruit Attenuates Atherosclerosis by Improving the Hypolipidemic and Antioxidant Activities in Apolipoprotein E-Deficient Mice

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