Effect of time interval between breast-conserving surgery and radiation therapy on ipsilateral breast recurrence

Froud, P; Mates, Donna; Jackson, Jeremy S. H.; Phillips, Norm; Andersen, Sandra; Jackson, Stewart M.; Bryce, C.; Olivotto, Ivo A.

doi:10.1016/s0360-3016(99)00412-5

Cited by 103 publications

(55 citation statements)

References 32 publications

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“…The adequacy of surgery can be judged by the incidence of positive surgical margins and the median number of axillary nodes dissected. In our study, positive resection margins were found in 7% women, and a median of 12 axillary nodes were dissected, which is comparable to most reports from large North American centers [4,29,30,32]. Similarly, optimal radiotherapy consisting of standard whole breast radiotherapy was given to all patients and an additional tumor bed boost was delivered in 98% patients.…”

Section: Discussionsupporting

confidence: 87%

“…Few previous studies have also shown that higher tumor grade is more common in non-Caucasian women [35][36][37][38]. Similarly, in contrast to only 17-37% incidence of ER or PR negative tumors in Western reports, in our study 66% tumors were ER negative and 58% were PR negative [31][32][33]. This finding of higher grade and hormone receptor negative tumors in a greater proportion of our patients may in part be explained by a younger patient population and larger tumor size.…”

Section: Discussioncontrasting

confidence: 52%

“…This may reflect relatively late presentation, possibly from lack of public awareness and no population-based breast cancer screening programs. Another important difference was that 70% of IDC in our study population were Grade III as compared to 28-46% Grade III tumors in most Western reports on Caucasian women [32][33][34]. Few previous studies have also shown that higher tumor grade is more common in non-Caucasian women [35][36][37][38].…”

Section: Discussionmentioning

confidence: 72%

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Safety and feasibility of breast conserving therapy in Indian women: Two decades of experience at Tata Memorial Hospital

et al. 2006

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Compared to Caucasians, these Indian women undergoing BCT were younger, had larger, higher grade, and receptor negative tumors. Comparable local control and survival was obtained by using stringent quality assurance in the diagnostic and therapeutic protocol. BCT, a resource intense treatment is safe for selected and motivated patients undergoing treatment at centers with adequate facilities and expertise even in countries with limited resources.

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Section: Discussionsupporting

confidence: 87%

Section: Discussioncontrasting

confidence: 52%

Section: Discussionmentioning

confidence: 72%

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Safety and feasibility of breast conserving therapy in Indian women: Two decades of experience at Tata Memorial Hospital

et al. 2006

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“…Therefore, a delay between surgery and the start of radiotherapy may increase the likelihood of tumor cell growth and development of radioresistance [2]. Several retrospective studies have yielded variable results [3][4][5][6][7][8]. Generally, in univariate analysis, an increased risk for local recurrence was observed with longer delay between surgery and the start of radiotherapy.…”

Section: Introductionmentioning

confidence: 99%

0110 Timing of radiotherapy and outcome in patients receiving adjuvant endocrine therapy

Karlsson¹,

Cole²,

Colleoni³

et al. 2009

The Breast

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Purpose-To evaluate the association between time from breast-conserving surgery (BCS) to radiotherapy and clinical outcome among patients treated with adjuvant endocrine therapy.Methods-Patient information was obtained from three International Breast Cancer Study Group trials. Analysis was restricted to 964 patients treated with BCS and adjuvant endocrine therapy. Patients were divided into two groups based on the median number of days between BCS and radiotherapy and into 4 groups based on the quartile of time between BCS and radiotherapy. Endpoints were time to local recurrence (TLR), disease-free survival (DFS) and overall survival (OS). Proportional hazards regression analysis was used to perform comparisons after adjustment for baseline factors.Results-The median time between BCS and radiotherapy was 77 days. Radiotherapy timing was significantly associated with age, menopausal status, and estrogen receptor status. After adjustment for these factors no significant effect of radiotherapy delay of up to 20 weeks was found. Adjusted hazard ratios (HRs) (radiotherapy within 77 days vs. after 77 days) were 0.94 (95% CI 0.47-1.87) for TLR, 1.05 (95% CI 0.82-1.34) for DFS and 1.07 (95% CI 0.77-1.49) for OS. For TLR the adjusted HRs for ≤48 days, 49-77 days, and 78-112 days were 0.90 (CI 95% 0.34-2.37), 0.89 (95% CI, 0.33-2.25), and 0.89 (95% CI, 0.33-2.41), respectively relative to ≥ 113 days.Conclusions-Radiotherapy delay of up to 20 weeks was significantly associated with baseline factors such as age, menopausal status, and estrogen-receptor status. After adjustment for these factors, timing of radiotherapy was not significantly associated with TLR, DFS, or OS.

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“…In other tumor sites such as head and neck or breast cancer, the delay to initiate PORT has been presented to have a negative impact on outcome (30)(31)(32)(33), while the data for lung cancer for this correlation is not reported much (34,35). A recent Canadian data documented 1,032 cases treated with POCT with a median time to adjuvant chemotherapy (TTAC) of 8 weeks where 35% of the cohort received POCT more than 10 weeks after surgery.…”

mentioning

confidence: 99%

Optimal sequencing of postoperative radiotherapy and chemotherapy in IIIA-N2 non-small cell lung cancer

Selek¹,

Chang²

2016

J. Thorac. Dis.

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Effect of time interval between breast-conserving surgery and radiation therapy on ipsilateral breast recurrence

Cited by 103 publications

References 32 publications

Safety and feasibility of breast conserving therapy in Indian women: Two decades of experience at Tata Memorial Hospital

Safety and feasibility of breast conserving therapy in Indian women: Two decades of experience at Tata Memorial Hospital

0110 Timing of radiotherapy and outcome in patients receiving adjuvant endocrine therapy

Optimal sequencing of postoperative radiotherapy and chemotherapy in IIIA-N2 non-small cell lung cancer

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