Effect of time-dependent cryotherapy on redox balance of quadriceps injuries

Silva, Marco Aurélio dos Santos; Carvalho, Taiara Ramos de; Cruz, Amanda Cristina Marques Barros da; Jesus, Lennon Rafael Guedine de; Neto, Larissa Alexsandra da Silva; Trajano, Eduardo Tavares Lima; Bezerra, Frank Silva

doi:10.1016/j.cryobiol.2016.01.001

Cited by 7 publications

(6 citation statements)

References 37 publications

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“…Previous researchers have shown that individuals submitted to cryotherapy have higher levels of antioxidants (6), decrease in oxidative stress (7), and lower levels of inflammation biomarker levels and mitochondrial dysfunction (8). On the other hand, other studies have proven that cryotherapy is not effective in muscle damage or inflammation biomarkers (9), or in decreasing oxidative stress induced by lesions (10). …”

Section: Introductionmentioning

confidence: 99%

Cryotherapy: biochemical alterations involved in reduction of damage induced by exhaustive exercise

Furtado

Hartmann

Martins

et al. 2018

Braz J Med Biol Res

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When exercises are done in intense or exhaustive modes, several acute biochemical mechanisms are triggered. The use of cryotherapy as cold-water immersion is largely used to accelerate the process of muscular recovery based on its anti-inflammatory and analgesic properties. The present study aimed to study the biochemical effects of cold-water immersion treatment in mice submitted to exercise-induced exhaustion. Swiss albino mice were divided into 4 treatment groups: control, cold-water immersion (CWI), swimming exhaustive protocol (SEP), and SEP+CWI. Treatment groups were subdivided into times of analysis: 0, 1, 3, and 5 days. Exhaustion groups were submitted to one SEP session, and the CWI groups submitted to one immersion session (12 min at 12°C) every 24 h. Reactive species production, inflammatory, cell viability, and antioxidant status were assessed. The SEP+CWI group showed a decrease in inflammatory damage biomarkers, and reactive species production, and presented increased cell viability compared to the SEP group. Furthermore, CWI increased acetylcholinesterase activity in the first two sessions. The present study showed that CWI was an effective treatment after exercise-induced muscle damage. It enhanced anti-inflammatory response, decreased reactive species production, increased cell viability, and promoted redox balance, which could decrease the time for the recovery process.

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Section: Introductionmentioning

confidence: 99%

Cryotherapy: biochemical alterations involved in reduction of damage induced by exhaustive exercise

Furtado

Hartmann

Martins

et al. 2018

Braz J Med Biol Res

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“…The benefits obtained by this technique can be explained by the ability of hypothermia to minimize the production of ROS and the resultant damage, which results from decreased metabolism and demand for oxygen in the ETC 67 , 68 . Other researchers have previously demonstrated the beneficial effects of tissue cooling in terms of ROS production 69 , 9 …”

Section: Discussionmentioning

confidence: 99%

Effects of cryotherapy on the regeneration process and muscular mechanical properties after lacerative injury model

Haupenthal

Silveira

Zaccaron

et al. 2020

Scandinavian Med Sci Sports

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Cryotherapy is a therapeutic modality widely used for the treatment of muscle injuries to control pain and inflammatory processes. This study aimed to investigate the effects of cryotherapy on the inflammatory and oxidative stress parameters and mechanical properties of, and pain in, the skeletal muscles of rats with lacerative muscle injury. The rats were anesthetized with 4% isoflurane and subjected to gastrocnemius muscle laceration injury. After injury, all animals in the intervention groups received cryotherapy treatment for 20 minutes using plastic bags containing crushed ice. The protocol comprised three daily applications at 3‐hour intervals on the day of injury, with reapplication 24 hours later. Seventy‐two male Wistar rats were divided into three groups: sham, muscle injury (MI), and MI + cryotherapy (MI + cryo). Muscle mechanical properties were analyzed by mechanical tensile testing on day 7 after injury. The MI + cryo group showed reduced TNF‐α, IFN‐γ, and IL1β levels; elevated IL4, IL6, and IL10 levels; reduced oxidant production and carbonyl levels; and elevated sulfhydryl contents. Animals that underwent tissue cooling showed superoxide dismutase activity and glutathione levels close to those of the animals in the sham group. The MI and MI + cryo groups showed reduced values of the evaluated mechanical properties and lower mechanical thresholds compared to those of the animals from the sham group. Our results demonstrated that the proposed cryotherapy protocol reduced the inflammatory process and controlled oxidative stress but did not reverse the changes in the mechanical properties of muscle tissues or provide analgesic effects within the time frame analyzed.

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“…Evidence[ 30 ] also indicates that skin temperature must reach 14.4 ℃ for analgesia and 13.8 ℃ to reduce local blood flow and obtain therapeutic benefits from the cold application. However, the surface temperature only decreases to 1-10 ℃ when ice is applied topically for the cooling of tissues from the baseline skin temperature[ 31 - 33 ]. Therefore, using an ice pack is always hard to achieve the particular low skin temperature to induce analgesia, while hyperbaric gaseous cryotherapy has the ability to shorten cooling time drastically and drop the skin temperature to about 4 ℃ through the sublimation of gas on the skin under high pressure.…”

Section: Hyperbaric Gaseous Cryotherapymentioning

confidence: 99%

Is it time to put traditional cold therapy in rehabilitation of soft-tissue injuries out to pasture?

Wang

2021

WJCC

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Cold therapy has been used regularly as an immediate treatment to induce analgesia following acute soft-tissue injuries, however, a prolonged ice application has proved to delay the start of the healing and lengthen the recovery process. Hyperbaric gaseous cryotherapy, also known as neurocryostimulation, has shown the ability to overcome most of the limitations of traditional cold therapy, and meanwhile promotes the analgesic and anti-inflammatory effects well, but the current existing studies have shown conflicting results on its effects. Traditional cold therapy still has beneficial effect especially when injuries are severe and swelling is the limiting factor for recovery after soft-tissue injuries, and therefore no need to be entirely put out to pasture in the rehabilitation practice. Strong randomized controlled trials with good methodological quality are still needed in the future to evaluate the effects of different cryotherapy modalities.

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Effect of time-dependent cryotherapy on redox balance of quadriceps injuries

Cited by 7 publications

References 37 publications

Cryotherapy: biochemical alterations involved in reduction of damage induced by exhaustive exercise

Cryotherapy: biochemical alterations involved in reduction of damage induced by exhaustive exercise

Effects of cryotherapy on the regeneration process and muscular mechanical properties after lacerative injury model

Is it time to put traditional cold therapy in rehabilitation of soft-tissue injuries out to pasture?

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