Effect of tiletamine–zolazepam on the intraocular pressure of the dog

Jang, Min; Park, Sangwan; Son, Won-gyun; Jo, Seunghyun; Hwang, Hyeshin; Seo, Kangmoon; Lee, Inhyung

doi:10.1111/vop.12237

Cited by 18 publications

(16 citation statements)

References 15 publications

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“…In the present study, regardless of age, sex, and eye side, the mean IOP value for Kangal dogs measured with TonoVet ® was 17.63 ± 3.34 mmHg, which was higher than mean IOPs obtained in three studies on Beagles and similar to mean IOPs in other studies in which different breeds were used (3,9,16,17). With regard to studies using applanation tonometers, mean IOPs obtained with Tono-Pen XL ® for Beagles ranged from 12.7 ± 0.8 to 15.3 ± 1.7 mmHg in one study (10) and was found to be 15.2 ± 2.2 mmHg in another (19). Another study using Tono-Pen XL ® in Labrador Retrievers determined their mean IOP as 11.93 ± 1.59 mmHg and 12.38 ± 2.10 mmHg (12).…”

Section: Methodsmentioning

confidence: 65%

Measurement of intraocular pressure in clinically normal Turkish Shepherd Dogs with the rebound tonometer (TonoVet®) and the applanation tonometer (Tono-Pen Vet®)

Kulualp¹,

Yurdakul²,

Erol³

et al. 2018

Medycyna Weterynaryjna

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Section: Methodsmentioning

confidence: 65%

Measurement of intraocular pressure in clinically normal Turkish Shepherd Dogs with the rebound tonometer (TonoVet®) and the applanation tonometer (Tono-Pen Vet®)

Kulualp¹,

Yurdakul²,

Erol³

et al. 2018

Medycyna Weterynaryjna

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“…IOP was measured under general anaesthesia. Tiletamine mixed with zolazepam did not have a significant effect on IOP in cats or dogs 34,35 , whereas Xylazine, especially at high doses, decreased IOP in rabbits 36,37 . Given those findings, the actual IOP might be similar to or greater than the measured IOP in this study.…”

Section: Discussionmentioning

confidence: 79%

Effects of aqueous suppressants and prostaglandin analogues on early wound healing after glaucoma implant surgery

Jung

Woo

Park

2019

Sci Rep

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A hypertensive phase frequently develops in the early postoperative period after glaucoma shunt operations. Anti-glaucoma eye drop use is essential when postoperative intraocular pressure (IOP) is not controlled. We investigated whether the use of early topical anti-glaucoma medication affects wound healing following glaucoma tube surgery. Eyes were randomly assigned to receive topical aqueous suppressant (timolol-dorzolamide fixed combination), prostaglandin (PG) analogue (travoprost), or normal saline (control group). First, we observed the effects of topical eye drops on Tenon’s tissue in non-operated eyes in rabbits. Second, we examined the effects of these eye drops on rabbit eyes that underwent Ahmed glaucoma drainage device implantation, including the effects on the histopathological appearance of their blebs. Interleukin-2 in the Tenon’s tissue was elevated in the PG group when compared to the control and aqueous suppressant groups (P = 0.006). In non-operated eyes, IOP was similar among the groups (P = 0.545). After glaucoma implant surgery, the average height of the inner collagenous layer and the average height of the α-SMA-positive blebs were the least in the aqueous suppressant group (P = 0.013, P = 0.001, respectively) at 4 weeks postoperatively. IOP was lower in the aqueous suppressant group than that in the control and PG groups (P = 0.001) following tube surgery. After Ahmed tube surgery, early treatment with aqueous suppressant decreased fibrosis in the bleb, but early treatment with the PG analogues did not.

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“…The combination of tiletamine + zolazepam (Zoletil ® 50, Virbac do Brazil Indústria e Comércio Ltda, Jurubatuba, SP, Brazil), detomidine (Dormiun-V ® 1%, Agener União Saúde Animal, São Paulo, SP, Brazil), and atropine (Atropina 1% Fagra ® , Mairiporã, SO, Brazil) was administered by intramuscular injection (IM). For detomidine hydrochloride, the model dose was 0.01 mg kg-1, recommended for a 500-kg horse (HAMM et al, 1995); for atropine sulfate, 0.05 mg kg-1 was used, as indicated for a 10-kg dog (UENO et al, 1999); for tiletamine + zolazepam, the model was 5.0 mg kg-1 based on a 10-kg dog (JANG et al, 2015).…”

Section: Experimental Designmentioning

confidence: 99%

Chemical restraint of jaguars Panthera onca Linnaeus, 1758 with allometrically scaled doses of tiletamine, zolazepam, detomidine, and atropine

Souza

Nascimento

Hirano

et al. 2018

SCA

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Chemical restraint of large felids is necessary for the handling, transportation, clinical assessment, and induction of anesthesia. The objective of this study was to evaluate the efficacy and safety of chemical restraint using a combination of tiletamine, zolazepam, detomidine, and atropine with interspecific allometric scaling doses in captive Panthera onca. There were ten males (two melanistic ones) and five females weighing between 35 and 80 kg. The evaluation of the chemical restraint protocol was carried out during routine management of the animals for physical examination, collection of blood and bone marrow samples, dental evaluation, and other procedures. During pre-established intervals, rectal temperature, heart rate, respiratory rate, nociception of thoracic and pelvic limbs, muscle relaxation and loss of the righting reflex were monitored. Loss of the righting reflex occurred at 8 ± 1.89 minutes post-injection (MPI). Respiratory rate returned at 77.6 ± 8.18 MPI; return of consciousness occurred at 112.6 ± 12.28 MPI, and complete recovery at 153 ± 12.47 MPI. There were no statistical differences between heart and respiratory rate means and oxyhemoglobin saturation. For rectal temperature, there was a significant reduction. The protocol analyzed was efficient for the chemical restraint of jaguars, enabling the manipulation, transportation, physical examination, dental evaluation, blood and bone marrow sample collection, and other minor invasive procedures of medium duration in these animals.

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Effect of tiletamine–zolazepam on the intraocular pressure of the dog

Abstract: The TZ combination had no clinically significant effect on IOP of the dog. This could be an option for induction or surgical procedures in dogs with ophthalmic problems when an increase in IOP is undesirable.

Cited by 18 publications

References 15 publications

Measurement of intraocular pressure in clinically normal Turkish Shepherd Dogs with the rebound tonometer (TonoVet®) and the applanation tonometer (Tono-Pen Vet®)

Measurement of intraocular pressure in clinically normal Turkish Shepherd Dogs with the rebound tonometer (TonoVet®) and the applanation tonometer (Tono-Pen Vet®)

Effects of aqueous suppressants and prostaglandin analogues on early wound healing after glaucoma implant surgery

Chemical restraint of jaguars Panthera onca Linnaeus, 1758 with allometrically scaled doses of tiletamine, zolazepam, detomidine, and atropine

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