Effect of Tiamulin in Chickens and Turkeys Infected Experimentally with Avian Mycoplasma

Baughn, Caroline; Alpaugh, W. C.; Linkenheimer, W. H.; Maplesden, D. C.

doi:10.2307/1589637

Cited by 21 publications

(6 citation statements)

References 2 publications

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“…The cure rate was significantly higher (P less than 0.05) in treated hens than in untreated hens, as early as 1 day after treatment. The findings also agree with Baughn et al (1978). He studied effect of tiamulin in chickens and turkeys infected experimentally with avian Mycoplasma.…”

Section: Resultssupporting

confidence: 82%

Efficacy of Tylosin and Tiamulin against Mycoplasmosis in poultry

Habib

Mahdy

Islam

et al. 2017

Res. Agric. Livest. Fish.

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Tylosin Tiamulin Mycoplasmosis Layer CRD Chronic respiratory disease (CRD) is one of the most important veterinary diseases inBangladesh and all over the world. Mortality, reducing of weight gain and increasing of feed conversion ratio (FCR) are caused by CRD. Several drugs are used for prevention and control of Mycoplasmosis. It is caused by Mycoplasma gallisepticum (MG). Tylosin and Tiamulin are effective on M. gallisepticum. By considering generating resistance against antibiotics that is effective on MG, studying the effect of these drugs in the treatment and prevention of Mycoplasmosis in birds were the purpose of this research. In this study, 36 layer birds (MG positive) of 25 weeks aged divided in three similar groups (A, B and C) contain 12 birds in each group. In group A; Tylosin was administered after mixing with 2.5 gm in 1 L drinking water, for Group B; Tiamulin was administered after mixing with feed @ 0.45gm/kg feed and Group C; Control (No antibiotic was given, only common feeding). The Serum Plate Agglutination (SPA) test was conducted; in positive cases granules were formed slowly which could be seen during rocking. In the negative case, no such granules were formed. Overall 6 and 9 serums shown negative SPA test in Group A and Group B, respectively. Therefore, the efficacy of Tylosin was 50.00% and the Tiamulin was 75.00% which resemble statistically significant (P<0.05). In control group, 5 birds were died during experiment. It can be concluded that usage of these antibiotics especially Tiamulin can be essential in the treatment and prevention of Mycoplasmosis in birds.

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Section: Resultssupporting

confidence: 82%

Efficacy of Tylosin and Tiamulin against Mycoplasmosis in poultry

Habib

Mahdy

Islam

et al. 2017

Res. Agric. Livest. Fish.

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“…Treatment with tiamulin improved weight gain compared with the untreated control chicks. As in the work of Baughn et al (1978), no gross lesions were observed in 90% of the chicks treated with tiamulin. When measured by the results of the cultural and serological tests, however, enrofloxacin was clearly more effective than tiamulin.…”

Section: Discussionsupporting

confidence: 59%

Studiesin vivoon the efficacy of enrofloxacin againstMycoplasma gallisepticum

Hinz¹,

Rottmann²

1990

Avian Pathology

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SUMMARYAfter a 5-day medication with drinking water containing 50 ppm enrofloxacin, Mycoplasma gallisepticum (MG) was culturally reisolated in only one of 80 broiler chicks and specific antibodies to MG were detected in none of the 40 birds tested. Medication with 50 ppm for 3 days and 25 ppm for 5 days was only slightly less effective. A significant decline in efficacy was observed, however, when enrofloxacin was added to the drinking water at 50 ppm for 1 day or 12.5 ppm for 5 days. Tiamulin was also significantly effective (250 ppm, 3 days). However, measured by the cultural reisolation of the pathogen and the presence of antibodies to MG. enrofloxacin (50 ppm, 3 days) proved to be more effective. Treatment with tylosin (50 ppm. 5 days) conferred no significant protection.

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“…Tiamulin is a limited-spectrum antibiotic, with antibacterial properties characterised by its high activity against Gram-positive bacteria, such as staphylococci and streptococci [9,10]; a variety of mycoplasmata [9][10][11][12][13][14][15]; and spirochetes, such as Brachyspira spp. [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Determination of Tiamulin Concentration in Sow Milk and in Sera of Suckling Piglets

Cybulski,

Gajda,

Bilecka

et al. 2023

Molecules

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Although modern analytical methods developed for monitoring antibiotics in several biological matrices are easily available, none of them have been applied to evaluate the transfer of tiamulin into sow milk. Therefore, this work was intended to analyse the concentrations of tiamulin in milk samples collected from lactating sows during and after a treatment consisting of three consecutive intramuscular applications of the antibiotic. The second aim of this investigation was to determine tiamulin concentrations in serum samples obtained from suckling piglets ingesting milk contaminated with the compound. Ultra-high-performance liquid chromatography coupled with tandem mass spectrometry (UHPLC-MS/MS) was used to quantify the analyte in both matrices. Our investigation proved tiamulin was transmitted into the milk of lactating sows. The mean concentration of the antibiotic among samples collected 3 h after administration was 1043 μg/L. The mean level of tiamulin on days 1 and 2 was 876 μg/L and 902 μg/L, respectively. The highest mean concentration of the antibiotic (1061 μg/L) was observed in samples collected on day 3. The mean concentration of the antibiotic in serum samples collected from 3-day-old piglets was 22.2 μg/L. The association between their body weight and serum tiamulin concentration was not statistically significant (p = 0.456).

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Effect of Tiamulin in Chickens and Turkeys Infected Experimentally with Avian Mycoplasma

Cited by 21 publications

References 2 publications

Efficacy of Tylosin and Tiamulin against Mycoplasmosis in poultry

Efficacy of Tylosin and Tiamulin against Mycoplasmosis in poultry

Studiesin vivoon the efficacy of enrofloxacin againstMycoplasma gallisepticum

Determination of Tiamulin Concentration in Sow Milk and in Sera of Suckling Piglets

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