Effect of Thyroxine Therapy on Serum Lipoproteins in Patients with Mild Thyroid Failure: A Quantitative Review of the Literature

Danese, Mark D.; Ladenson, Paul W.; Meinert, Curtis L.; Powe, Neil R.

doi:10.1210/jc.85.9.2993

Cited by 273 publications

(214 citation statements)

References 56 publications

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“…A recent meta-analysis including 13 studies showed no effect of L-thyroxine therapy on HDL-C and TG concentrations (36). In our study, a significant decrease in HDL-C levels was observed after initiation of L-thyroxine therapy both in the treated group as a whole and in the subgroup with higher initial TSH levels.…”

Section: Discussionsupporting

confidence: 46%

“…A number of studies suggest a decrease of TC and LDL-C after L-thyroxine-substitution (11, 15, 24 -27), whereas others report no significant changes (22, 28 -34). It appears that the degree of change depends on two parameters: the initial levels of cholesterol (35,36) and the degree of thyroid dysfunction (17). Indeed, in the subgroups of patients with 'more severe' hypothyroidism (namely TSH $ 10 mU=ml) or high baseline levels of TC ($240 mg/dl), there was a significant response of TC and LDL-C to treatment.…”

Section: Discussionmentioning

confidence: 99%

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Lipid profile in subclinical hypothyroidism: is L-thyroxine substitution beneficial?

Efstathiadou¹,

Bitsis²,

Milionis

et al. 2001

European Journal of Endocrinology

112

105

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Objective: The significance of dyslipidemia in subclinical hypothyroidism (SH) and the effect of thyroid substitution on lipids remain controversial. The present study aimed to assess the association of SH with lipid abnormalities and to quantify the effect of L-thyroxine therapy on serum lipid profiles. Design: Serum lipid parameters of 66 patients with SH and 75 age-and sex-matched euthyroid controls were evaluated in a cross-sectional study. Results: Patients with SH had higher total cholesterol (TC) ð222^45 (S.D.) vs 190^32 mg=dlÞ; lowdensity lipoprotein cholesterol (LDL-C) ð139^28 vs 118^39 mg=dlÞ; apolipoprotein B ð149^21 vs 139^18 mg=dlÞ and lipoprotein (a) (Lp(a)) (median 12.5 (0.8-101) mg/dl vs 7 (0.8 -44) mg/dl) levels compared with euthyroid controls (P , 0:05 for all comparisons). In a follow-up study including 37 patients with SH, all measurements were repeated after restoration of a euthyroid state with incremental doses of L-thyroxine. No significant changes in serum lipid profiles were observed except for a decrease in high-density lipoprotein cholesterol ð59^15 to 55^14 mg=dl; P , 0:05Þ: However, patients with high pre-treatment TC ($240 mg/dl) showed a significant reduction in both TC ð278^28 vs 257^36 mg=dl; P , 0:05Þ and LDL-C ð192^23 vs 173^28 mg=dl; P , 0:01Þ levels. Similar but more pronounced changes were observed in a subgroup of patients with pre-treatment levels of TSH $10 mU/ml. Thyroid autoimmunity had no effect on either the baseline or the posttreatment lipid profile. Conclusion: Although patients with subclinical hypothyroidism exhibit increased levels of the atherogenic parameters (mainly LDL-C and Lp(a)), thyroid substitution therapy does not seem to significantly improve dyslipidemia in the whole group of patients.

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Section: Discussionsupporting

confidence: 46%

Section: Discussionmentioning

confidence: 99%

Lipid profile in subclinical hypothyroidism: is L-thyroxine substitution beneficial?

Efstathiadou¹,

Bitsis²,

Milionis

et al. 2001

European Journal of Endocrinology

112

105

View full text Add to dashboard Cite

show abstract

“…Obesity caused by hypothyroidism can be distinguished from that resulting primarily from physical inactivity and a reduced resting metabolic rate by virtue of the accompanying dramatic elevations of thyroid-stimulating hormone (TSH) levels. Sub-clinical hypothyroidism, characterized by elevated TSH levels but normal thyroid hormone levels, is associated with dyslipidemia and an increased risk of ischemic heart disease and mortality (Danese et al 2000, Hak et al 2000, Visscher & Seidell 2001, Imaizumi et al 2004, Moulin de Moraes et al 2005. Previous studies have shown that, when adjusted for body mass index, leptin levels are positively correlated with TSH (Iacobellis et al 2005).…”

Section: Introductionmentioning

confidence: 99%

TSH stimulates adipogenesis in mouse embryonic stem cells

Lü¹,

Lin²

2007

Journal of Endocrinology

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Although TSH is the main regulator of thyroid growth and function, TSH binding activity in fat has long been reported. Since the TSH receptor (TSHR) has been detected in both preadipocytes and adipocytes, we hypothesized that it may play a role in adipose differentiation. Here, we use an in vitro model of adipogenesis from mouse embryonic stem (ES) cells to define TSH function. Directed differentiation of ES cells into the adipose lineage can be achieved over a 3-week period. Although adipocyte differentiation is initiated early in the development of cultured ES cells, TSHR up-regulation is precisely correlated with terminal differentiation of those adipocytes. The adipocytes express TSHR on the cell surface and respond to TSH with increased intracellular cAMP production, suggesting the activation of the protein kinase A signaling pathway. To determine whether TSH impacts adipogenesis, we examined how adipocytes responded to TSH at various points during their differentiation from cultured ES cells. We found that TSH greatly increases adipogenesis when added in the presence of adipogenic factors. More importantly, our data suggest that TSH also stimulates adipogenesis in cultured ES cells even in the absence of adipogenic factors. This finding provides the first evidence of TSH being a pro-adipogenic factor that converts ES cells into adipocytes. It further highlights the potential of ES cells as a model system for use in the study of TSH's role in the regulation of physiologically relevant adipose tissue.

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“…Several studies have also shown that thyroxin therapy has led to significant improvement in dyslipidemia in SCH patients, but we have not studied this aspect. 23 In contrast, in overt hypothyroidism, elevation of serum HDL-C levels may be seen due to increased concentration of HDL2 particles. 24 Considering our results about the lipid levels, our study showed a significantly higher LDL in SCH as in comparison with the studies undertaken in EU, no worth mentioning changes were seen in HDL in both the groups we studied.…”

Section: Discussionmentioning

confidence: 99%

Correlation between Thyrotropin and Fasting Lipid Profile in Patients of Sub Clinical Hypothyroidism

Zubair

Ijaz²,

Aftab³

2017

Annals KEMU

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A controversy exists regarding the association between subclinical hypothyroidism (SCH) and dyslipidemia. Moreover, studies on lipid ratios in SCH are rare, particularly in Asian Countries. The study also aims to find out whether any correlation exists between serum TSH levels and fasting lipid levels, which would indirectly affect morbidity and mortality. Methods:The study was conducted at Physiology department, KEMU and Centre for Nuclear Studies KEMU & Mayo Hospital, Lahore which is a tertiarycare center. It was a cross-sectional study carried out over a period of 6 months. Control group consisted of 50 euthyroid persons taken from a population coming for whole-body health checkup. Case group consisted of 50 patients with SCH. Confounding variables were removed. Fasting blood samples were taken in a plain gel vaccutainer tube with an aseptic blood collection technique. The samples were centrifuged within 1 h at 3000 rpm for 5 min. These were 1 Assistant Professor of Physiology

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Effect of Thyroxine Therapy on Serum Lipoproteins in Patients with Mild Thyroid Failure: A Quantitative Review of the Literature

Cited by 273 publications

References 56 publications

Lipid profile in subclinical hypothyroidism: is L-thyroxine substitution beneficial?

Lipid profile in subclinical hypothyroidism: is L-thyroxine substitution beneficial?

TSH stimulates adipogenesis in mouse embryonic stem cells

Correlation between Thyrotropin and Fasting Lipid Profile in Patients of Sub Clinical Hypothyroidism

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