Effect of thyroxine replacement on serum IGF‐I, IGFBP‐3 and the acid‐labile subunit in patients with hypothyroidism and hypopituitarism

Schmid, Christoph; Zwimpfer, Cornelia; Brändle, Michael; Krayenbühl, Pierre‐Alexandre; Zapf, J.; Wiesli, Peter

doi:10.1111/j.1365-2265.2006.02652.x

Cited by 25 publications

(26 citation statements)

References 33 publications

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“…Hypothyroid humans also have consistently been shown to have a decrease in serum IGF-1 concentration. [67][68][69] Similar decreases in GH and IGF-1 concentration have been reported for hypothyroid rodents as well. 70,71 Dogs appear to be unique in having an increase in circulating GH and IGF-1, compared with other species that have a decrease or no change in these hormones with hypothyroidism.…”

Section: Discussionsupporting

confidence: 67%

Effect of hypothyroidism on insulin sensitivity and glucose tolerance in dogs

Hofer‐Inteeworn¹,

Panciera²,

Monroe³

et al. 2012

ajvr

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Hypothyroidism appeared to negatively affect glucose homeostasis by inducing insulin resistance, but overall glucose tolerance was maintained by increased insulin secretion in hypothyroid dogs. Possible factors affecting insulin sensitivity are high serum GH and IGF-1 concentrations and an increase in abdominal fat. In dogs with diseases involving impaired insulin secretion such as diabetes mellitus, concurrent hypothyroidism can have important clinical implications.

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Section: Discussionsupporting

confidence: 67%

Effect of hypothyroidism on insulin sensitivity and glucose tolerance in dogs

Hofer‐Inteeworn¹,

Panciera²,

Monroe³

et al. 2012

ajvr

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“…In contrast to the study performed by Willemsen et al [19], they reported that IGF-1 and resistin levels increased significantly after treatment with GH [20]. Schmid et al detected that T4 replacement increased IGF-1 level in primary and central hypothyroid patients [21]. They reported that administration of thyroid hormone to the patients with GH deficiency increased IGF-1 level [21].…”

Section: Discussionmentioning

confidence: 97%

Serum Resistin and Insulin-Like Growth Factor-1 Levels in Patients with Hypothyroidism and Hyperthyroidism

Koyuncu

Yildirmak

Temizel

et al. 2013

Journal of Thyroid Research

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Introduction. The aim of this study was to evaluate the serum levels of resistin and insulin-like growth factor-1 (IGF-1) and and also the potential relationship between thyroid function and levels of resistin and IGF-1 in hypothyroid and hyperthyroid patients. Methods. Fifteen cases of hypothyroid (HT), 16 of subclinically hypothyroid (SCHT), 15 of hyperthyroid (HrT), 15 of subclinically hyperthyroid (SCHrT), and 17 healthy individuals have been included in the study. Serum resistin levels were measured using enzyme-linked immunosorbent assay and IGF-1 and thyroid stimulating hormone (TSH) levels by chemiluminescence method. Results. Resistin levels in total HT group were significantly higher than in controls (12.66 ± 6.04 and 8.45 ± 2.90 ng/mL, resp.). In SCHrT subgroup resistin levels were significantly higher than those of controls (14.88 ± 7.73 and 8.45 ± 2.90 ng/mL, resp.). IGF-1 levels were significantly lower in total HT than in total HrT and control groups (117.22 ± 52.03, 155.17 ± 51.67, and 184.00 ± 49.73 ng/mL, resp.). Furthermore IGF-1 levels in HT subgroup were significantly lower compared to controls (123.70 ± 44.03 and 184 ± 49.73 ng/mL, resp.). In SCHT subgroup IGF-1 levels were significantly lower than those of control and SCHrT groups (111.11 ± 59.35, 184.00 ± 49.73, and 166.60 ± 47.87 ng/mL, resp.). There were significant correlations between IGF-1 and TSH in HT subgroup and between resistin and TSH in total HrT group. Conclusion. It was concluded that increased resistin levels are directly related to thyroid dysfunction, and GH/IGF-1 axis is influenced in clinically or subclinically hypothyroidism patients.

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“…Similarly, Bona et al [28] documented that in the patients with hypothyroidism - both congenital and caused by thyroiditis - L-T 4 replacement led to physiological increase of IGF-I and IGFBP-3 secretion. Moreover, Schmid et al [29] showed that, during L-T 4 replacement, IGF-I and acid-labile subunit secretion increased in the patients with both primary and central hypothyroidism, while IGFBP-3 - only in those with primary hypothyroidism. In 2008, Akin et al [30] reported that GH-IGF axis was affected in the patients with subclinical hypothyroidism and that L-T 4 replacement therapy could prevent abnormalities related to GH-IGF axis in them.…”

Section: Discussionmentioning

confidence: 99%

Thyroid function in children with growth hormone (GH) deficiency during the initial phase of GH replacement therapy - clinical implications

et al. 2010

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BackgroundNormal thyroid hormone secretion or appropriate L-thyroxine (L-T4) substitution is necessary for the optimal effect of the growth hormone (GH) administration on growth rate. The decrease of free thyroxine (FT4) levels at recombinant human GH (rhGH) therapy onset has been reported in several studies. The aim of the present study was to evaluate the effect of rhGH administration on thyrotropin (TSH) and FT4 serum concentrations in children with GH deficiency (GHD) during the 1st year of therapy, as well as to assess potential indications to thyroid hormone supplementation in them.Patients and methodsThe analysis involved data of 75 children (59 boys, 16 girls) with disorders of GH secretion (GHD, neurosecretory dysfunction - NSD) and partial GH inactivity (inactGH), who were treated with rhGH for - at least - one year. In all the children, body height and height velocity (HV) were assessed before and after 1 year of therapy, while TSH, FT4, IGF-I and IGFBP-3 before treatment and after 3-6 months and 1 year of treatment. In the patients, who revealed hypothyroidism (HypoT), an appropriate L-T4 substitution was introduced immediately. The incidence of HypoT, occurring during the initial phase of rhGH therapy, was assessed, as well as its influence on the therapy effectiveness.ResultsBefore rhGH substitution, there were no significant differences in either auxological indices or TSH and FT4 secretion, or IGF-I concentration and its bioavailability among the groups of patients. During the initial 3-6 months of rhGH administration, a significant decrease of FT4 serum concentration, together with a significant increase of IGF-I SDS and IGF-I/IGFBP-3 molar ratio was observed in all the studied groups. In 17 children, HypoT was diagnosed and L-T4 substitution was administered. Despite similar IGF-I secretion increase, the improvement of HV presented significantly lower in children with HypoT than in those who remained euthyroid all the time.ConclusionsThe incidence of HypoT during the initial phase of GH treatment in children with GHD and the negative effect of even transient thyroid hormone deficiency on the growth rate should be taken into account.

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Effect of thyroxine replacement on serum IGF‐I, IGFBP‐3 and the acid‐labile subunit in patients with hypothyroidism and hypopituitarism

Cited by 25 publications

References 33 publications

Effect of hypothyroidism on insulin sensitivity and glucose tolerance in dogs

Effect of hypothyroidism on insulin sensitivity and glucose tolerance in dogs

Serum Resistin and Insulin-Like Growth Factor-1 Levels in Patients with Hypothyroidism and Hyperthyroidism

Thyroid function in children with growth hormone (GH) deficiency during the initial phase of GH replacement therapy - clinical implications

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