Effect of thyroxine injection on bone growth in malnourished rats at different growth stages.

Kanagawa, Yoshihiro; Funaba, Masayuki; Matsui, Tohru; Yano, Hideo; Kawashimai, Ryoji

doi:10.3177/jnsv.33.55

Cited by 2 publications

(1 citation statement)

References 9 publications

(4 reference statements)

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“…Initially, 150 articles were identified through the electronic search: 144 in PubMed/Medline, 1 in LILACS, 0 in SciELO and 5 in the Cochrane Library. After the implementation of inclusion and exclusion criteria, only 5 articles were included in the systematic review: Heinrichs et al;Nakamoto & Miller (1979); Even-Zohar et al (2008); Kuramitsu et al (1985), and Kanagawa et al (1987), (Table I).…”

Section: Resultsmentioning

confidence: 99%

How Does Protein Malnutrition or Food Deprivation Interfere with the Growth of the Epiphyseal Plate in Animals?

Silva¹,

Silva

Costa

et al. 2013

Int. J. Morphol.

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the aim of this study was to conduct a literature review of impacts of protein malnutrition and/or early food deprivation on the formation of the growth plate in young animals. A search was performed using the databases PubMed/MEDLINE, LILACS, SciELO and the Cochrane Library, without language restrictions or any limit as to year. Initially, 150 articles were identified, however, after application of the inclusion and exclusion criteria only five remained. In three studies the nutritional stress was due to protein malnutrition, another due to fasting and the fifth was due to food restriction. All the studies had some methodological omissions. The studies included in this review-demonstrated corroboration in the results obtained, regardless of whether the animals had been subjected to protein malnutrition, fasting or food restriction. The findings uncovered were reduction in height of the epiphyseal plate, in the number of proliferative and hypertrophic chondrocytes, in the bone growth rate and in the longitudinal length of the bone in animals subjected to nutritional stress. In this systematic review, it was possible to observe the susceptibility of the epiphyseal plate in the first place, and secondarily, of the long bones to the effects of nutritional stress by means of protein malnutrition or food deprivation applied in young animals.

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