Effect of Thymol on the spontaneous contractile activity of the smooth muscles

Study of total phenol, flavonoids contents and phytochemical screening of various leaves crude extracts of locally grown Thymus vulgaris

“…Its stem and branches are quadrangular. The leaves of this plant are [6][7][8][9][10][11][12] mm long, oval, blunt, entire, margin revolute, thick, smooth, dotted with many oil-glands, paler, pubescent beneath. It blooms flowers from June to July.…”

“…Extensive clinical studies have been done and reported by several scientists on this plant species and showed that they have very strong antibacterial, antioxidant, antifungal, insecticidal and anti platelet activities [10,11] . The researchers showed that they also have anti infectious, gynaecological effect and contractile activities of the smooth muscles [12] . Generally, the activities of crude extracts obtained from medicinal plants may be subjected to change based on the variations of chemical composition.…”

Effects of 1.8-cineole (eucalyptol) on the spontaneous contractile activity of smooth muscles fibre

“…Our objective was to investigate whether cineole in lower concentrations can specifically interact with receptors on smooth muscle fibre (SMF) as has been shown for thymol before (Beer et al, 2007). Figure 1A shows the effect of 0.025 µl cineole (1.5 × 10 -5 M) (in 20 ml organ bath) on the spontaneous contractile activity (SCA) of smooth muscle fibre (SMF) from guinea pig stomach.…”

“…The concentration interval between the specific and non-specific effects usually is in the range of two orders of magnitude. In our previous work (Beer et al, 2007) we have shown that another monoterpene, thymol, which also has strong antiinflammatory and antispasmodic effects at concentrations less than 10 -6 M, shows an agonistic effect on the α 1 and α 2 adrenoreceptors.…”

Does essential oil of Carum copticum affect acetylcholine-induced contraction in isolated rats Ileum?

“…The essential oil of C. copticum constitutes of pinene components (Prakash et al, 2006), thymol (Hisayama, 1983;Beer et al, 2007) and carvacrol (Aydin and Seker, 2005) which have potent relaxant effect (Boskabady et al, 2003). From these components, the anti cholinergic activity of thymol was also reported (Hisayama, 1983), on the basis of our previous studies in which CCAE showed a significant muscle relaxant effect and also regarding the present study that EO has had a potent relaxing effect; it could be concluded that observed relaxation effect of EO may be through the thymol action.…”