Effect of three anthelmentics on disposition kinetics of florfenicol in goats

Atef, M.; El-Gendi, A. Y. I.; Amer, Aziza M.; El‐Aty, A. M. Abd

doi:10.1016/j.fct.2010.08.039

Cited by 21 publications

(23 citation statements)

References 25 publications

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“…Pretreatment of chickens with toltrazuril two days before tilmicosin administration is sufficient time to prompt liver microsomal CYP 450 proteins, in spite of the fact that Abo ElSooud (2003) found that a single dose of albendazole was adequate to affect such induction in goats. Moreover, this result was in agreeing with that recorded by (Atef et al 2010) who found that goats pre-treated with rafoxanide or albendazole demonstrated a significant decline in serum florfenicol level when contrasted with non-anthelmintic treated goats. Amprolium, diclazuril and toltrazuril brought about a significance diminish in the elimination half-life and the area under serum concentration-time curve contrasted with tilmicosin alone.…”

Section: Resultssupporting

confidence: 81%

Effect of three anticoccidials on pharmacokinetics of tilmicosin in broiler chickens

El-Hewaity¹

2016

IJPT

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The disposition kinetic of tilmicosin (25mg/kg) was studied following oral administration alone, pretreated with amprolium (240 ppm), pretreated with diclazuril (2.5 ppm) and pretreated with toltrazuril (25 ppm) in broiler chickens. The serum tilmicosin concentrations were determined by microbiological assay technique using Bacillus subtilis (ATCC 6633) as the test organism. Following oral administration of tilmicosin, the disposition curve was best described by two-compartment open model. The maximum serum concentration (C max ) was 1.90 ± 0.11, 1.27 ± 0.13, 1.50 ± 0.14 and 1.41 ± 0.11µg/ml for tilmicosin alone and in the presence of amprolium, diclazuril and toltrazuril, respectively. The elimination half-life (T 0.5 (el) ) was significantly decreased (5.28 ± 0.30, 5.88 ± 0.33, 6.03 ± 0.25 h, respectively) in amprolium, diclazuril and toltrazuril pretreated broiler chicken compared to tilmicosin alone (7.30 ± 0.41 h). The outcomes illustrated a significant decrease in the interval between doses in amprolium, diclazuril and toltrazuril pretreated broiler chicken compared to tilmicosin alone. Amprolium diclazuril and toltrazuril, resulted in a significance decrease in AUC (12.02 ± 1.14, 15.50 ± 1.26 and 14.56 ± 1.46 µg.h.ml -1 , respectively) compared to tilmicosin alone (21.98±1.83 µg.h.ml -1 ). It is concluded that the administration of amprolium, diclazuril and toltrazuril before tilmicosin would altered its pharmacokinetic profile in broiler chicken.

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Section: Resultssupporting

confidence: 81%

Effect of three anticoccidials on pharmacokinetics of tilmicosin in broiler chickens

El-Hewaity¹

2016

IJPT

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“…The serum cefoperazone concentrations were significantly decreased at different time intervals in both nitroxynil (25%) and nitroxynil (34%) treated goats as compared to non-anthelmintic-treated goats. The present results were, too consistent with [30], who found that; goats pre-treated with rafoxamide at a dose of 7.5 mg/kg b.wt, subcutaneously or albendazole at a dose of 7.5 mg/kg b.wt orally showed a significant decrease in serum florfenicol concentration level as compared to non-anthelmintic-treated animals. Co-administration of nitroxynil in both different concentration (25% and 34%) subcutaneously 9 h earlier to intramuscular injection of cefoperazone significantly shortened the elimination half-life T 0.5 (el) compared with that in non-anthelmintic treated goats.…”

Section: Discussionsupporting

confidence: 82%

“…The kinetic parameters recorded in the present research revealed that cefoperazone behaved differently in both nitroxynil (25%) and nitroxynil (34%) treated goats as compared to non-anthelmintic-treated goats wheres C max , AUC and F% value, are significantly decreased. This finding is in agreement with [30]. In this respect, the enzyme induction leads to an increased rate of biotransformation and corresponding decrease in the availability of the parent drug and consequently may lead to alteration of kinetic parameters [32].…”

Section: Discussionsupporting

confidence: 80%

Pharmacokinetic interaction of nitroxynil and cefoperazone in goats

El-Hewaity¹

2015

IJBAS

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The pharmacokinetic aspects of cefoperazone (CEFO) were investigated via intravenous (IV), and intramuscular (IM) injections in clinically healthy goats at a dose of 20 mg/kg b.wt. Goats were pre-treated with nitroxynil (25%) or nitroxynil (34%) subcutaneously in a dose 10 mg/kg b.wt, respectively. Cefoperazone was injected intramuscularly nine hours following anthelmintic administration, and blood samples were taken by jugular venipuncture at standardized intervals. Cefoperazone concentrations in serum were determined by microbiological assay technique. Goats pre-treated with nitroxynil (25%) or nitroxynil (34%) showed a significant decrease in serum cefoperazone level as compared to non-anthelmintic treated goats. The obtained data revealed that administration of nitroxynil in both concentrations negatively affected most of the cefoperazone parameters. In this respect, the elimination half-life T 0.5(el) , C max , AUC, and the systemic bioavailability (F %) were significantly decreased in both groups of nitroxynil-treated goats compared to non-anthelmintic treated goats. On the other hand, there were no significance differences between both nitroxynil (25% and 34%) treated goats. Concomitant administration of nitroxynil (25% and 34%) with cefoperazone resulted in significant alterations in the disposition kinetic of cefoperazone in goats. Consequently, the interaction between nitroxynil and cefoperazone could be of clinical significance and may require monitoring and adjustment of cefoperazone dosage.

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“…After duplicate articles were removed, titles and abstracts of articles were reviewed by two authors, producing 35 articles , of which 17 were included in the review [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25]. Eighteen articles were excluded for the following reasons: eight articles used animals [26][27][28][29][30][31][32][33]; two articles contained only in vitro data [34,35]; two articles did not contain any pharmacokinetic data of either albendazole or mebendazole [36,37]; two articles only contained data on drug-food interactions [38,39]; and four articles did not contain data on any drug interactions with either albendazole or mebendazole [40][41][42][43]. Pharmacokinetic parameters of albendazole and mebendazole can be found in Tables 1 and 2.…”

Section: Search Resultsmentioning

confidence: 99%

A Review of Pharmacokinetic Drug–Drug Interactions with the Anthelmintic Medications Albendazole and Mebendazole

et al. 2015

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Medications indicated for helminthes and other parasitic infections are frequently being used in mass populations in endemic areas. Currently, there is a lack of guidance for clinicians on how to appropriately manage drug interactions when faced with patients requiring short-term anthelmintic therapy with albendazole or mebendazole while concurrently taking other agents. The objective of this review was to systematically summarize and evaluate published literature on the pharmacokinetics of albendazole or mebendazole when taken with other interacting medications. A search of MEDLINE (1946 to October 2014), EMBASE (1974 to October 2014), International Pharmaceutical Abstracts (1970 to October 2014), Google, and Google Scholar was conducted for articles describing the pharmacokinetics of albendazole or mebendazole when given with other medications (and supplemented by a bibliographic review of all relevant articles). Altogether, 17 articles were included in the review. Studies reported data on pharmacokinetic parameters for albendazole or mebendazole when taken with cimetidine, dexamethasone, ritonavir, phenytoin, carbamazepine, phenobarbital, ivermectin, praziquantel, diethylcarbamazine, azithromycin, and levamisole. Cimetidine increased the elimination half-life of albendazole and maximum concentration (Cmax) of mebendazole; dexamethasone increased the area under the plasma concentration-time curve (AUC) of albendazole; levamisole decreased the Cmax of albendazole; anticonvulsants (phenytoin, phenobarbital, carbamazepine) decreased the AUC of albendazole; praziquantel increased the AUC of albendazole; and ritonavir decreased the AUC of both albendazole and mebendazole. No major interactions were found with ivermectin, azithromycin, or diethylcarbamazine. Future research is required to clarify the clinical relevance of the interactions observed.

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Effect of three anthelmentics on disposition kinetics of florfenicol in goats

Cited by 21 publications

References 25 publications

Effect of three anticoccidials on pharmacokinetics of tilmicosin in broiler chickens

Effect of three anticoccidials on pharmacokinetics of tilmicosin in broiler chickens

Pharmacokinetic interaction of nitroxynil and cefoperazone in goats

A Review of Pharmacokinetic Drug–Drug Interactions with the Anthelmintic Medications Albendazole and Mebendazole

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