Effect of thiomolybdate and ammonium molybdate in pregnant guinea pigs and their offspring

Howell, J. M.; Shunxiang, Y.; Gawthorne, J. M.

doi:10.1016/0034-5288(93)90085-t

Cited by 12 publications

(4 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the exocrine parts of pancreas, degeneration, acinar irregularity and loss of basement membranes were seen in groups 1 and 3 animals. Similar pancreatic lesions have been described in copper deficient rats [ 15 , 9 , 26 ], in cattle [ 13 ] and in guinea pigs with molybdenosis [ 25 ]. It may be speculated that these alterations contributed to the maldigestion and malnutrition and also the decreased feed intake and loss of body weight in the goats [ 18 ].…”

Section: Discussionsupporting

confidence: 72%

Experimental Copper Deficiency, Chromium Deficiency and Additional Molybdenum Supplementation in Goats – Pathological Findings

2001

View full text Add to dashboard Cite

Secondary copper (Cu) deficiency, chromium (Cr) deficiency and molybdenosis (Mo) has been suggested to cause the "mysterious" moose disease in the southwest of Sweden. The present experiment was performed on goats to investigate the clinical, chemical, and pathological alterations after 20 months feeding of a semi-synthetic diet deficient in Cu and Cr. Four groups were included in the study: control group (n = 4), Cu-deficient group (group 1, n = 4), Cr-deficient group (group 2, n = 2) and Cu+Cr-deficient group (group 3, n = 3). Group 3 was additionally supplemented with tetrathiomolybdate during the last 2 months of the experiment. Main histopathological findings in groups 1 and 3 were the lesions in the liver, characterised by a severe active fibrosis, bile duct proliferation, haemosiderosis and mild necroses. Additionally, degenerative alterations of the exocrine pancreas were prominent in groups 1 and 3. Lesions in group 3 were more pronounced than in group 1. In group 3, the skin showed an atrophic dermatosis, while in group 2 a crusty dermatitis caused by Candida spp. was observed. This study shows that liver, pancreas and skin are mainly affected by a long term deficiency of copper and the findings are complicated by molybdenum application while chromium deficiency produced no histomorphological effects in our study.

show abstract

Section: Discussionsupporting

confidence: 72%

Experimental Copper Deficiency, Chromium Deficiency and Additional Molybdenum Supplementation in Goats – Pathological Findings

2001

View full text Add to dashboard Cite

show abstract

“…None of the organs showed any pathological changes between the study and control animals. In animal studies of rats and guinea pigs, the highest Mo tissue concentrations after oral Mo intake were measured in the kidneys [30,31,34]. Murray et al reported no macroscopic pathological findings.…”

Section: Histological Organ Analysismentioning

confidence: 99%

Biocompatibility and Degradation Behavior of Molybdenum in an In Vivo Rat Model

et al. 2021

View full text Add to dashboard Cite

The biocompatibility and degradation behavior of pure molybdenum (Mo) as a bioresorbable metallic material (BMM) for implant applications were investigated. In vitro degradation of a commercially available Mo wire (ø250 µm) was examined after immersion in modified Kokubo’s SBF for 28 days at 37 °C and pH 7.4. For assessment of in vivo degradation, the Mo wire was implanted into the abdominal aorta of female Wistar rats for 3, 6 and 12 months. Microstructure and corrosion behavior were analyzed by means of SEM/EDX analysis. After explantation, Mo levels in serum, urine, aortic vessel wall and organs were investigated via ICP-OES analysis. Furthermore, histological analyses of the liver, kidneys, spleen, brain and lungs were performed, as well as blood count and differentiation by FACS analysis. Levels of the C-reactive protein were measured in blood plasma of all the animals. In vitro and in vivo degradation behavior was very similar, with formation of uniform, non-passivating and dissolving product layers without occurrence of a localized corrosion attack. The in vitro degradation rate was 101.6 µg/(cm2·d) which corresponds to 33.6 µm/y after 28 days. The in vivo degradation rates of 12, 33 and 36 µg/(cm2·d) were observed after 3, 6 and 12 months for the samples properly implanted in the aortic vessel wall. This corresponds with a degradation rate of 13.5 µm/y for the 12-month cohort. However, the magnitude of degradation strongly depended on the implant site, with the wires incorporated into the vessel wall showing the most severe degradation. Degradation of the implanted Mo wire neither induced an increase in serum or urine Mo levels nor were elevated Mo levels found in the liver and kidneys compared with the respective controls. Only in the direct vicinity of the implant in the aortic vessel wall, a significant amount of Mo was found, which, however, was far below the amounts to be expected from degrading wires. No abnormalities were detected for all timepoints in histological and blood analyses compared to the control group. The C-reactive protein levels were similar between all the groups, indicating no inflammation processes. These findings suggest that dissolved Mo from a degrading implant is physiologically transported and excreted. Furthermore, radiographic and µCT analyses revealed excellent radiopacity of Mo in tissues. These findings and the unique combination with its extraordinary mechanical properties make Mo an interesting alternative for established BMMs.

show abstract

“…23 Early animal experiments in chicks, poults, mice and pigs showed that Mo can stimulate early development in a dose-dependent manner. [23][24][25][26] Moreover, Mo-containing metals and alloys (for example, Ti-7.5Mo, 27 Ti-15Mo-1Bi, 28 Co-Cr-Mo 29 and Ti-12Mo-6Zr-2Fe 30 ) exhibited excellent mechanical properties and biocompatibility and have been widely used as orthopedic and dental implants. However, to the best of our knowledge, studies of Mo-containing tissue engineering scaffolds for bone regeneration have not yet been reported.…”

Section: Introductionmentioning

confidence: 99%

A 3D-printed scaffold with MoS2 nanosheets for tumor therapy and tissue regeneration

Wang

et al. 2017

NPG Asia Mater

137

View full text Add to dashboard Cite

The treatment of malignant bone tumors is a significant clinical challenge because it requires the simultaneous removal of tumor tissues and regeneration of bone defects, and bifunctional three-dimensional (3D) scaffolds that function in both tumor therapy and tissue regeneration are expected to address this need. In this study, novel bifunctional scaffolds (MS-AKT scaffolds) were successfully fabricated by combining a 3D printing technique with a hydrothermal method. During the hydrothermal process, MoS 2 nanosheets were grown in situ on the strut surface of bioceramic scaffolds, endowing them with photothermal therapeutic potential. Under near-infrared (NIR) irradiation, the temperature of the MS-AKT scaffolds rapidly increased and was effectively modulated by varying the MoS 2 content, scaffold sizes and laser power densities. The photothermal temperature significantly decreased the viability of osteosarcoma cells and breast cancer cells and inhibited tumor growth in vivo. Moreover, the MS-AKT scaffolds supported the attachment, proliferation and osteogenic differentiation of bone mesenchymal stem cells and induced bone regeneration in vivo. This bifunctional scaffold, which treats the tumor and facilitates bone growth, offers a promising clinical strategy to treat tumor-induced bone defects. This proof-of-concept study demonstrates the feasibility of localized tumor therapy and tissue regeneration in diverse tissue engineering applications using multifunctional biomaterials.

show abstract

Effect of thiomolybdate and ammonium molybdate in pregnant guinea pigs and their offspring

Cited by 12 publications

References 30 publications

Experimental Copper Deficiency, Chromium Deficiency and Additional Molybdenum Supplementation in Goats – Pathological Findings

Experimental Copper Deficiency, Chromium Deficiency and Additional Molybdenum Supplementation in Goats – Pathological Findings

Biocompatibility and Degradation Behavior of Molybdenum in an In Vivo Rat Model

A 3D-printed scaffold with MoS2 nanosheets for tumor therapy and tissue regeneration

Contact Info

Product

Resources

About