Effect of thin carbonate-containing apatite (CA) coating of titanium fiber mesh on trabecular bone response

Abstract

The influence of thin carbonate-containing apatite (CA) coating on trabecular bone response to cylindrical titanium fiber mesh (porosity of 85%, pore size of 200-300 microm, 2.8 mm diameter x 6 mm length) implants was investigated. Thin CA coatings were deposited by the so-called molecular precursor method. Molecular precursor solution was obtained by adding dibutylammonium diphosphate salt to Ca-EDTA/amine ethanol solution by adjusting Ca/P = 1.67. Sintered cylindrical titanium fiber mesh was immersed into molecular precursor solution and then tempered at 600 degrees C for 2 h. The immersion and tempering process was repeated three times. An adherent thin CA film could be deposited on the inside of titanium fiber mesh. After the immersion of a CA-coated titanium fiber mesh in simulated body fluid, apatite crystals precipitated on the titanium fiber mesh. Uncoated and CA-coated titanium fiber mesh was inserted into the trabecular bone of the left and right femoral condyles of rabbits. Histological and histomorphometrical evaluation revealed a significantly greater amount of bone formation inside the porous area of the CA-coated titanium fiber mesh after 12 weeks of implantation. The present results suggested that a thin CA-coated titanium mesh has better osteoconductivity and will be useful for a three-dimensional scaffold.

Regeneration of Periodontal Ligament for Apatite-coated Tooth-shaped Titanium Implants with and without Occlusion Using Rat Molar Model

“…Adherent HA coating of several micrometers could be easily deposited on titanium. It is possible to deposit uniform apatite coating onto three-dimensional complexly shaped materials, such as porous materials 23) . In the present study, uniform apatite coating could be deposited not only on the root surface but also on the root furcation of tooth-shaped titanium implants by an immersion and heating process.…”

Enhancement of Apatite Precipitation on an Alkaline Hydrolyzed Poly (Lactic acid-ε-Caprolactone) Film in Simulated Body Fluid

“…Hanawa et al 15,16) also found that apatite formed on a titanium surface after immersion in Hank's balanced salt solution (HBSS) without organic species at pH=7.4 and reported on the efficacy of HBSS as an SBF. Hayakawa et al 17) demonstrated apatite formation on a thin Ca coated titanium fiber mesh surface after immersion in HBSS by a thin Ca coating using the molecular precursor method. Thus, previous results reported by Kitahara et al 8) suggested that hydrolyzed PLA will be effective for bone formation because of the progression of apatite precipitation.…”

Guided Bone Regeneration using Hydroxyapatite-Coated Titanium Fiber Web in Rabbit Mandible: Use of Molecular Precursor Method

“…In addition, the dissolution of Ca 2+ from the coating forms a supersaturated interface condition, followed by the deposition a mineral layer. The molecular precursor method is a simple technique in which a uniform coating of thin HA on the TW is easily achieved 13,21) . Previously, a biomimetic process using simulated body fluid was reported 22,23) .…”