Effect of thiamethoxam on the behavioral profile alteration and toxicity of adult zebrafish at environmentally relevant concentrations

Yang, Jiangtao; Guo, Changsheng; Luo, Ying; Fan, Jingpu; Wang, Weimin; Yin, Xingxing; Xu, Jian

doi:10.1016/j.scitotenv.2022.159883

Cited by 13 publications

(5 citation statements)

References 62 publications

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“…A similar phenomenon has been reported in fish. The locomotor activity, such as enhanced aggregation and social activity, and increased abnormal swimming behavior, of adult zebrafish exposed to low concentrations (0.1 and 10 μg/L) of THM for 45 days was increased (Yang et al., 2023 ). Individual exposure to 1 mg/L nicotine for 3 min prevented conspecific alarm substance (CAS)‐induced anxiogenic‐like behaviors such as bottom‐dwelling, freezing, erratic movements in zebrafish (Duarte et al., 2019 ).…”

Section: Discussionmentioning

confidence: 99%

“…When juveniles of the cyprinid fish Alburnus alburnus were exposed to 78 mg/L THM (using the insecticide Actara containing THM as active ingredient) significant increases in carbohydrate, lipid, and protein levels were observed after 28 days of treatment (Rania & Zaidi, 2023 ). Furthermore, it is reported that zebrafish exposed to a low concentration of THM (0.1 μg/L) for 45 days exhibited a range of abnormal behaviors, including anxiety, hyperactivity, high aggregation, excessive panic, and memory (Yang et al., 2023 ). However, there is still insufficient research on the effects of NEO on aquatic vertebrates, including issues such as what non‐NEOs would be better for animals and the environment if the use of NEOs were discontinued.…”

Section: Introductionmentioning

confidence: 99%

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Exposure to neonicotinoid pesticides induces physiological disorders and affects color performance and foraging behavior in goldfish

Kakuta,

Takase

2024

Physiological Reports

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We investigated the effects of neonicotinoid pesticides (NEOs) on the spontaneous swimming and foraging behavior, as well as the morphological and physiological changes of goldfish. Most fish reared in thiamethoxam (THM)‐sprayed rice fields showed the scales easily peeled off, and increased ascites. Some individuals showed decreased bio‐defense activity and low plasma Ca2+. Similar changes were found in the exposure test to THM (1.0 and 20.0 μg/L) and dinotefuran (1.2 and 23.5 μg/L). Next, the effects of a low concentration of THM (1.0 μg/L) on the spontaneous swimming and foraging behavior of fish were examined. Fish exposed to THM for 1 week became restless and had increased the swimming performance, especially under natural light, white LED lighting and blue LED lighting. Goldfish exposed to THM had also increased intake of shiny white beads under green LED illumination. These results indicate that the exposure to NEO, even for a short period and at low levels, not only suppressed bio‐defense activities and metabolic abnormalities, but also stress response, the swimming and foraging behavior of the fish are likely to be significantly suffered.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exposure to neonicotinoid pesticides induces physiological disorders and affects color performance and foraging behavior in goldfish

Kakuta,

Takase

2024

Physiological Reports

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“…MNPs, known to impact the nervous system, can cause behavioral changes in zebrafish [ 54 ]. Exposure to MNPs has been associated with alterations in swimming behavior and anxiety-like behaviors in adult fish [ 55 ].…”

Section: Association Of Behavioral Changes With Reproductive Toxicitymentioning

confidence: 99%

Behavioral Studies of Zebrafish Reveal a New Perspective on the Reproductive Toxicity of Micro- and Nanoplastics

Wu,

Yu,

et al. 2024

Toxics

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The escalating prevalence of microplastics and nanoplastics in aquatic environments is a major challenge affecting the behavior and reproductive health of aquatic organisms while posing potential risks to human health and ecosystems. This review focuses on the neurobehavioral changes and reproductive toxicity of MNPs in zebrafish and their relationships. At the same time, the neurobehavioral changes caused by MNPs were studied, and the synergistic effects of the interaction of these pollutants with other environmental contaminants were explored. In addition, zebrafish, as a model organism, provide valuable insights into the subtle but important effects of MNPs on reproductive behavior, which is critical for understanding reproductive success, suggesting that behavioral changes can serve as an early biomarker of reproductive toxicity. In addition, based on classical endocrine disruptor models and behavioral research methods, the current status of the research on the reproductive toxicity of MNPs in zebrafish was reviewed, which further indicated that the behavioral parameters of zebrafish can be used as an effective and rapid tool to evaluate the reproductive toxicity of MNPs. However, behavioral methods for rapidly assessing the toxicity of MNPs are still an area of exploration. To address limitations and challenges in the current scope of research, this review outlines future research directions with the aim of improving our understanding of the environmental and health impacts of MNPs. This work aims to inform targeted environmental policies and advance public health strategies to address the growing challenge of MNPs pollution.

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“…TMX was one of the neonicotinoids most frequently found in fruits and vegetables (Yi et al 2023 ), with detection rates of 51% and 53% in studies done in Hangzhou (China) and the US Congressional Cafeteria, respectively (Lu et al 2018 ). According to a US Geological Survey investigation, THM was found in surface waters that were contaminated with neonicotinoids insecticides at a rate of 21% (Hladik and Kolpin 2016 ); TMX can cause fish to behave abnormally in response to environmental cues, which could have an impact on an ecosystem (Yang et al 2023 ). TMX has been found in water sources all over the world, including drinking water (Chen et al 2018a , b ), subterranean (Davranche et al 2019 ), and surface water (Chrétien et al 2017 ; Casillas et al 2022 ).…”

Section: Introductionmentioning

confidence: 99%

“…The Pearl River had 4.97–102 ng/L TMX. The USA has 8.93 g/L TMX remnants, Germany 2.82 g/L, and the Netherlands 225 g/L (Yang et al 2023 ). Additionally, the low reference dose of TMX points to a high relative toxicity of TMX (Jameel et al 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Induction of apoptosis, oxidative stress, hormonal, and histological alterations in the reproductive system of thiamethoxam-exposed female rats

El-Din

Ghareeb

El-Garawani

et al. 2023

Environ Sci Pollut Res

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The present study aimed to investigate the oral toxic effects of 1/10 LD50 and 1/5 LD50 of thiamethoxam (TMX), a neonicotinoid insecticide, on the reproductive system of female Wistar rats. Thirty female rats were divided into three groups and supplied orally with either; saline solution, 1/10 LD50 of TMX (156 mg/kg) or 1/5 LD50 of TMX (312 mg/kg). The daily administration was extended for 30 days. Investigating the parameters of oxidative stress, hormonal levels, histopathological alterations, and the apoptotic markers (P53, BAX, BCL-2, and caspase-3) was performed in the uterus and ovary of rats. Results showed significant changes in the body weight gain, and relative weight of the left and right ovaries and uterus. Moreover, luteinizing hormone (LH), estradiol (ED), and progesterone (PG) serum levels were not significantly altered following TMX oral administration. The level of follicle-stimulating hormone in the TMX-exposed group (156 mg/kg) was significantly increased; however, a significant decrease was observed in TMX-exposed animals (312 mg/kg). TMX induced significant oxidative stress in exposed groups by reducing the activities of superoxide dismutase (SOD), glutathione (GSH), and catalase (CAT), and elevating malondialdehyde (MDA) levels. Following hematoxylin and eosin staining, the microscopic examination revealed deteriorated luteal cells with vacuolation in the corpus luteum, a follicle containing a degenerated oocyte and degeneration/necrosis of the circular muscle layer with a high rate of apoptotic cells in TMX-exposed animals. TMX induced transcriptional alterations in apoptosis-related genes shifting towards the activation of the intrinsic apoptotic pathway. Collectively, results suggest the toxic effect of the TMX on the reproductive health of female Wistar rats.

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Effect of thiamethoxam on the behavioral profile alteration and toxicity of adult zebrafish at environmentally relevant concentrations

Cited by 13 publications

References 62 publications

Exposure to neonicotinoid pesticides induces physiological disorders and affects color performance and foraging behavior in goldfish

Exposure to neonicotinoid pesticides induces physiological disorders and affects color performance and foraging behavior in goldfish

Behavioral Studies of Zebrafish Reveal a New Perspective on the Reproductive Toxicity of Micro- and Nanoplastics

Induction of apoptosis, oxidative stress, hormonal, and histological alterations in the reproductive system of thiamethoxam-exposed female rats

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