Effect of Thermoresponsive Poly(L-lactic acid)–poly(ethylene glycol) Gel Injection on Left Ventricular Remodeling in a Rat Myocardial Infarction Model

Somekawa, Shota; Mahara, Atsushi; Masutani, Kazunari; Kimura, Yoshiharu; Urakawa, Hiroshi; Yamaoka, Tetsuji

doi:10.1007/s13770-017-0067-9

Cited by 27 publications

(13 citation statements)

References 30 publications

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“…The PLA scaffold avoided soft tissue adherence on the mandible, but it was not so effective for human adipose derived stem cells' (hADSCs) osteogenic differentiation in vitro. Somekawa and colleagues [183] used PLA to make an aqueous suspension have a sol-gel transition for gel behaviour at body temperature. This gel composite proved highly useful in preventing left ventricular remodelling after myocardial infarction in rat models.…”

Section: Bioplastics Polymers As Implants In Vivomentioning

confidence: 99%

Recent Advances in Bioplastics: Application and Biodegradation

et al. 2020

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The success of oil-based plastics and the continued growth of production and utilisation can be attributed to their cost, durability, strength to weight ratio, and eight contributions to the ease of everyday life. However, their mainly single use, durability and recalcitrant nature have led to a substantial increase of plastics as a fraction of municipal solid waste. The need to substitute single use products that are not easy to collect has inspired a lot of research towards finding sustainable replacements for oil-based plastics. In addition, specific physicochemical, biological, and degradation properties of biodegradable polymers have made them attractive materials for biomedical applications. This review summarises the advances in drug delivery systems, specifically design of nanoparticles based on the biodegradable polymers. We also discuss the research performed in the area of biophotonics and challenges and opportunities brought by the design and application of biodegradable polymers in tissue engineering. We then discuss state-of-the-art research in the design and application of biodegradable polymers in packaging and emphasise the advances in smart packaging development. Finally, we provide an overview of the biodegradation of these polymers and composites in managed and unmanaged environments.

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Section: Bioplastics Polymers As Implants In Vivomentioning

confidence: 99%

Recent Advances in Bioplastics: Application and Biodegradation

et al. 2020

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“…In addition, a greater reduction in LV cavity area was observed for the PLLA-PEG/PDLA-PEG gel in comparison with the alginate gel. 135 Synthetic polymers, however, have some drawbacks such as a lack of cell attachment and less biocompatibility in cardiac tissue engineering. 136…”

Section: Poly(ethylene Glycol)mentioning

confidence: 99%

<p>Biodegradable Nanopolymers in Cardiac Tissue Engineering: From Concept Towards Nanomedicine</p>

Nasr¹,

Rabiee²,

Hajebi³

et al. 2020

IJN

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Cardiovascular diseases are the number one cause of heart failure and death in the world, and the transplantation of the heart is an effective and viable choice for treatment despite presenting many disadvantages (most notably, transplant heart availability). To overcome this problem, cardiac tissue engineering is considered a promising approach by using implantable artificial blood vessels, injectable gels, and cardiac patches (to name a few) made from biodegradable polymers. Biodegradable polymers are classified into two main categories: natural and synthetic polymers. Natural biodegradable polymers have some distinct advantages such as biodegradability, abundant availability, and renewability but have some significant drawbacks such as rapid degradation, insufficient electrical conductivity, immunological reaction, and poor mechanical properties for cardiac tissue engineering. Synthetic biodegradable polymers have some advantages such as strong mechanical properties, controlled structure, great processing flexibility, and usually no immunological concerns; however, they have some drawbacks such as a lack of cell attachment and possible low biocompatibility. Some applications have combined the best of both and exciting new natural/ synthetic composites have been utilized. Recently, the use of nanostructured polymers and polymer nanocomposites has revolutionized the field of cardiac tissue engineering due to their enhanced mechanical, electrical, and surface properties promoting tissue growth. In this review, recent research on the use of biodegradable natural/synthetic nanocomposite polymers in cardiac tissue engineering is presented with forward looking thoughts provided for what is needed for the field to mature.

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“…The most notable polyesters are FDA-approved polycapralactone, poly-L-lactic acid, and poly(lactic-co-glycolic acid), which have been applied in many tissue engineering applications (29). It is essential to use biocompatible and biodegradability gels in order to avoid both long-term bioreactions and toxic inflammatory reactions (30).…”

Section: A) Biomimetic Scaffoldsmentioning

confidence: 99%

Advances in tissue engineering of the cardiac muscle for myocardial regeneration

Andrés¹

2020

Actual. Med.

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Tissue engineering is currently at the avant-garden of research and aims to build regenerative alternatives in vitro by means of combining a scaffold material, adequate cells and bioactive molecules. It has been 20 years since the initial description of a tissue engineering construct, but in relation to the management of heart disease, these new technologies are not yet fully established, due to the challenges presented by their transfer to the clinic. However, advancements are being made into these therapies, and therefore it necessary, for example, support to academic laboratories, adequate funding, cooperation between different laboratories by coordinating comparable approaches and evidence-based information. Generally, scaffold materials such as gelatin, collagen alginate or synthetic polymers and cardiac cells are used to reconstitute native tissue-like constructs in vitro. They should have propensity to intgrate and remain contractile in vivo. This review aim is to present cardiac tissue engineering strategies for the functional recovery of altered cardiac tissue with a focus on different methods of application, neovascularization, advances in 3D bioprinting and future perspectives. Resumen La ingeniería de tejidos está actualmente en la vanguardia de la investigación y tiene como objetivo construir alternativas regenerativas in vitro mediante la combinación de un material de andamiaje, células adecuadas y moléculas bioactivas. Han pasado 20 años desde la primera descripción de una construcción de ingeniería tisular, pero en relación con el manejo de las enfermedades cardiacas, estas nuevas tecnologías aún no están completamente establecidas, por los desafíos que presenta su traslación a la clínica. No obstante, se está progresando con estas terapias y por ello se necesita, por ejemplo, apoyo a los laboratorios académicos, financiación adecuada, cooperación entre los distintos laboratorios mediante la coordinación de enfoques comparados e información basada en evidencia. Generalmente, se utilizan materiales de andamiaje como gelatina, colágeno, alginato o polímeros sintéticos y células cardíacas para reconstuir in vitro constructos similares a los tejidos nativos. Estos deben ser propensos a integrarse y permanecer contráctiles in vivo. El objetivo de esta revisión es presentar las principales estrategias de ingeniería tisular para la recuperación funcional del tejido cardiaco alterado con un enfoque en los distintos métodos, la neovascularización, los avances en la bioimpresión 3D y las perspectivas futuras.

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Effect of Thermoresponsive Poly(L-lactic acid)–poly(ethylene glycol) Gel Injection on Left Ventricular Remodeling in a Rat Myocardial Infarction Model

Cited by 27 publications

References 30 publications

Recent Advances in Bioplastics: Application and Biodegradation

Recent Advances in Bioplastics: Application and Biodegradation

<p>Biodegradable Nanopolymers in Cardiac Tissue Engineering: From Concept Towards Nanomedicine</p>

Advances in tissue engineering of the cardiac muscle for myocardial regeneration

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