Effect of thermomechanical pre-treatment on short- and long-term Ni release from biomedical NiTi

Freiberg, Katharina; Bremer-Streck, Sibylle; Kiehntopf, Michael; Rettenmayr, Markus; Undisz, Andreas

doi:10.1016/j.actbio.2014.01.003

Cited by 24 publications

(10 citation statements)

References 39 publications

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“…The Ni enrichment in the metal/oxide interface requires attention, because if the layer TiO 2 is thin and/or contains cracks, Ni 2-ions may move to the surface, causing irreversible toxic effects due to their accumulation in tissues 26 . Therefore, the increased thickness of the TiO 2 layer is very important because it acts as a physical barrier that effectively blocks the transport of ions to the Ni 2-surface 27 .…”

Section: Resultsmentioning

confidence: 99%

Oxide Formation on NiTi Surface: Influence of the Heat Treatment Time to Achieve the Shape Memory

et al. 2015

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Several studies regarding superficial treatments of Nitinol (NiTi) shape-memory have been developed aiming to the improve corrosion resistance and to block the Ni release to adjacent tissues. The necessary heat treatment to achieve the shape memory effect normally occurs at temperatures between 500 and 600 °C. However, titanium oxide (TiO 2 ) is formed on the NiTi surface during the shape memory process heat treatment. In this work the effects of the heat treatment time on the surface characteristics of the formed NiTi oxide, at temperatures that promote the shape-memory (530 and 570 °C), were evaluated. The TiO 2 layers which were obtained were evaluated by X-ray diffraction (XRD), energy dispersive X-ray (EDX), scanning electron microscope (SEM), thermogravimetric analysis (TGA), wettability and roughness. The results show that by increasing the exposure time at the temperature of 570 °C the formation of a thicker oxide is promoted, with less superficial roughness and of a hydrophobic nature. According to the literature, these characteristics indicate that the obtained oxide layer has properties that accelerat the osseointegration process.

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Section: Resultsmentioning

confidence: 99%

Oxide Formation on NiTi Surface: Influence of the Heat Treatment Time to Achieve the Shape Memory

et al. 2015

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“…Many in vitro studies examined NiTi archwires in static environments by putting them in different media and determining the level of released nickel [20,21]. Some experimental research deformed NiTi archwires only using one-dimensional loading, or failed to deform them at all.…”

Section: Introductionmentioning

confidence: 99%

Characterisation of NiTi Orthodontic Archwires Surface after the Simulation of Mechanical Loading in CACO2-2 Cell Culture

et al. 2019

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Nickel-titanium (NiTi) orthodontic archwires are crucial in the initial stages of orthodontic therapy when the movement of teeth and deflection of the archwire are the largest. Their great mechanical properties come with their main disadvantage—the leakage of nickel. Various in vitro studies measured nickel leakage from archwires that were only immersed in the medium with little or minimal simulation of all stress and deflection forces that affect them. This study aims to overcome that by simulating deflection forces that those archwires are exposed to inside the mouth of a patient. NiTi orthodontic archwires were immersed in CACO2-2 cell culture medium and then immediately loaded while using a simulator of multiaxial stress for 24 h. After the experiment, the surface of the NiTi orthodontic archwires were analysed while using scanning electron microscopy (SEM) and auger electron spectroscopy (AES). The observations showed significant microstructural and compositional changes within the first 51 nm thickness of the archwire surface. Furthermore, the released nickel and titanium concentrations in the CACO2-2 cell culture medium were measured while using Inductively Coupled Plasma Mass Spectroscopy (ICP-MS). It was found out that the level of released nickel ions was 1.310 µg/L, which can be assigned as statistically significant results. These data represent the first mention of the already detectable release of Ni ions after 24 h during the simulation of mechanical loading in the CACO2-2 cell culture medium, which is important for clinical orthodontic praxis.

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“…Laboratory trials show that there is almost no release of material into the tissue [16]. Therefore, it is expected that the marker will remain stable in the tissue for several months, in contrast to some non-metallic clip markers.…”

Section: Reasons For the Choice Of Implant Materialsmentioning

confidence: 99%

Using a New Marker Clip System in Breast Cancer: Tumark Vision® Clip - Feasibility Testing in Everyday Clinical Practice

Rüland¹,

Hagemann²,

Reinisch³

et al. 2018

Breast Care

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Background: This study presents first feasibility experiences with a new 3-dimensional (3D) marker clip system in clinical practice. The rate of clinical complete responses in the treatment of breast cancer patients is increasing; additionally, a change to targeted axillary dissection is being considered after neoadjuvant chemotherapy (NACT). Consequently, marker clips are needed which are reliable and easy to handle even in the axillary lymph node system. Methods: A total of 50 patients from the Breast Care Unit of the Kliniken Essen Mitte were included. Clip marking of all 50 primary breast cancer lesions as well as 23 lymph nodes was performed using the Tumark Vision® clip. Following application, the position and visibility of the marker clip were monitored and documented in 2 axes. Results: The feasibility of the Tumark Vision clip was excellent in everyday clinical practice as none of the markers dislocated. After clip marking of the tumor region and/or suspicious lymph nodes, all Tumark Vision clips could be detected in both axes. The 3D shape could be observed in all cases after application. Conclusion: The new 3D-shaped marker clip seems to be a promising tool for marking breast cancer lesions and even lymph nodes before NACT. As there are many studies ongoing to prove the feasibility of a shift from standard axillary dissection after NACT towards targeted axillary dissection, the Tumark Vision clip seems to provide good visibility even in lymph nodes after NACT. Further studies are warranted.

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Effect of thermomechanical pre-treatment on short- and long-term Ni release from biomedical NiTi

Cited by 24 publications

References 39 publications

Oxide Formation on NiTi Surface: Influence of the Heat Treatment Time to Achieve the Shape Memory

Oxide Formation on NiTi Surface: Influence of the Heat Treatment Time to Achieve the Shape Memory

Characterisation of NiTi Orthodontic Archwires Surface after the Simulation of Mechanical Loading in CACO2-2 Cell Culture

Using a New Marker Clip System in Breast Cancer: Tumark Vision® Clip - Feasibility Testing in Everyday Clinical Practice

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