Effect of Thermolabile Toxin from Yersinia pseudotuberculosis on Functions of Innate Immunity Cells

Abstract

The thermolabile toxin of Yersinia pseudotuberculosis produces a selective dose-dependent stimulating effect on functional activity of innate immunity cells. Prolonged apoptosis-inducing action of the toxin was associated with activation of enzymes of the oxygen-dependent system (LDH and myeloperoxidase) at the early terms of observation (up to 3 h). In turn, increased number of macrophages with apoptotic changes was noted at the early stages of contact with the thermolabile toxin (5 h), and its further growth was observed against the background of activation of mitochondrial enzymes and production of NO metabolites.

Far Eastern Scarlet-Like Fever is a Special Clinical and Epidemic Manifestation of Yersinia pseudotuberculosis Infection in Russia

“…Timchenko from the Y. pseudotuberculosis strain 2517 of the third serovar containing plasmid pYV (a strain obtained from H. Mollaret, France), as well as from a plasmid-free strain. The dose-dependent selective effect of this toxin on the functional activity of innate immunity cells was established [ 72 ]. The activation of oxygen-dependent enzymes of mice neutrophils (lactate dehydrogenase and myeloperoxidase) was detected in the early period of contact (up to 3 h).…”

“…The activation of oxygen-dependent enzymes of mice neutrophils (lactate dehydrogenase and myeloperoxidase) was detected in the early period of contact (up to 3 h). In turn, there was an increase in the number of apoptotic macrophages in the early stages of contact with TLT (5 h) and their high level during the observation period (21 days) with a simultaneous increase in cytochrome oxidase activity and nitric oxide production [ 72 ]. Pathomorphological studies have shown [ 73 ] that this toxin is directly related to the development of infectious-toxic shock in Y. pseudotuberculosis infection.…”