Effect of therapy hypothermia on hemodynamic status of post cardiac arrest in acute myocardial infarction

Ifadah, Erlin; Susanti, Fajar; Sunadi, Apri; Jamiatun,; Chaerunnisa, Dilla

doi:10.1016/j.enfcli.2019.12.033

Cited by 1 publication

(1 citation statement)

References 9 publications

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“…Recent studies have shown that mild hypothermia adjuvant therapy has been widely used in clinical research and clinical treatment of a variety of brain diseases, such as neonatal hypoxic‐ischemic encephalopathy, severe craniocerebral injury (Ifadah et al., 2020; Lijun et al., 2020). Mild hypothermia plays a positive role in the treatment of hypoxic‐ischemic encephalopathy (Chawla et al., 2020; Lijun et al., 2020) and can protect the body from a variety of cellular pressure.…”

Section: Introductionmentioning

confidence: 99%

Mild hypothermia improves brain injury in rats with intracerebral hemorrhage by inhibiting IRAK2/NF‐κB signaling pathway

Shi

et al. 2020

Brain and Behavior

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Objective To explore the effect of mild hypothermia on nerve injury by establishing a rat model of intracerebral hemorrhage (ICH), and to clarify the specific molecular mechanism of mild hypothermia in improving brain injury in ICH rats. Methods The rat model of ICH was established by collagenase injection. The neurological deficit score (NDS), brain tissue water detection, and Nissl staining were applied to detect the degree of brain injury. ELISA was used to analyze the expression of proinflammatory cytokines and serum nerve injury indexes. Flow cytometry and Western Blot were used to detect neuronal apoptosis. Results Mild hypothermia treatment significantly improved the brain injury of the ICH rats and down‐regulated the inflammatory response and oxidative stress in the brain tissue. Moreover, mild hypothermia also effectively inhibited IRAK2/NF‐κB signaling pathway and thus affect neuronal apoptosis. Conclusion Mild hypothermia alleviates inflammatory response and neuronal apoptosis by inhibiting IRAK2/NF‐κB signaling pathway in the ICH rats thus improving brain injury.

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Section: Introductionmentioning

confidence: 99%

Mild hypothermia improves brain injury in rats with intracerebral hemorrhage by inhibiting IRAK2/NF‐κB signaling pathway

Shi

et al. 2020

Brain and Behavior

View full text Add to dashboard Cite

show abstract

Effect of therapy hypothermia on hemodynamic status of post cardiac arrest in acute myocardial infarction

Cited by 1 publication

References 9 publications

Mild hypothermia improves brain injury in rats with intracerebral hemorrhage by inhibiting IRAK2/NF‐κB signaling pathway

Mild hypothermia improves brain injury in rats with intracerebral hemorrhage by inhibiting IRAK2/NF‐κB signaling pathway

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