Effect of Therapeutic Theophylline Levels on the Sleep Quality and Daytime Cognitive Performance of Normal Subjects

Fitzpatrick, Michael; Engleman, Heather M.; Boellert, Frederika; McHardy, Robert J.; Shapiro, Colin M.; Deary, Ian J.; Douglas, Neil J.

doi:10.1164/ajrccm/145.6.1355

Cited by 33 publications

(5 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, therapeutic serum levels, 11.0 pg/mL, were achieved and sleep time was reduced by 1 h. One can also ask about the clinical significance of reducing sleep by 1 h. Several studies have now shown that reducing sleep by as little as 1 h can accu¬ mulate across nights to reduce daytime alertness and disturb performance.21 In the present study, therapeutic serum levels, 11.0 pg/mL, were achieved and sleep time was reduced by 1 h. One can also ask about the clinical significance of reducing sleep by 1 h. Several studies have now shown that reducing sleep by as little as 1 h can accu¬ mulate across nights to reduce daytime alertness and disturb performance.21…”

Section: Discussionmentioning

confidence: 62%

Effects of Theophylline on Nocturnal Sleep and Daytime Sleepiness/Alertness

Roehrs

Merlotti

Halpin

et al. 1995

Chest

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 62%

Effects of Theophylline on Nocturnal Sleep and Daytime Sleepiness/Alertness

Roehrs

Merlotti

Halpin

et al. 1995

Chest

View full text Add to dashboard Cite

“…The results of several previous studies with oral theophylline have shown no significant effects on sleep quality, 22,30 while other studies have provided evidence that the medication causes sleep disturbance. 20,31 In one such study, normal nonasthmatic patients were examined in order to eliminate asthma effects on sleep.…”

Section: Discussionmentioning

confidence: 98%

Salmeterol vs Theophylline

Wiegand

Mende

Zaidel

et al. 1999

Chest

View full text Add to dashboard Cite

“…Of in-terest, on the higher serum theophylline concentration there was a marked reduction in the amount of oxygen desaturation that occurred overnight. Other studies on normal subjects 24,25 have really shown minimal to no adverse effects of theophylline and sleep characteristics or daytime function.…”

Section: Theophyllinesmentioning

confidence: 90%

Chronotherapy of Asthma: How to Use Standard Medications for Better Results

Martin¹

1994

Semin Respir Crit Care Med

View full text Add to dashboard Cite

What exactly is the area of medical chronobiology, chronopharmacology, and chronotherapy? Actually, biologic rhythms are ubiquitous in nature. This includes plants and insects and proceeds through the phylogenetic ladder to humans. Chronobiology is defined as the scientific discipline that studies the intrinsic biologic rhythms of all life forms. The vast majority of physicians have never come into contact with the science of chronobiology either during their medical school or through their postgraduate training. What we have all faced is the concept that the human being is a homeostatic organism with a constant state of governing principles. Thus, in using therapeutic interventions for our patients we have actually been forced into the process of constant blood levels and equally divided dosing schedules throughout the 24-hour cycle. However, as more information about the nonhomeostatic processes involved in health and disease is learned, we are developing new principles on how to use common medications more appropriately and with better results. These nonhomeostatic processes that occur in humans are intrinsic biologic rhythms, which coordinate biochemical, endocrine, and physiological functions and have evolved to meet the differential requirements for energy substrates during activity or during the sleep-related hours. This concept of chronobiology is not new to medicine, but because it is a different type of view than the dominating theory of homeostasis it has not been widely taught to us as physicians treating diseases.As is becoming more evident, the conceptual and actual differences between the homeostasis and chronobiologic principles are not merely academic but can play a major role in disease and therapy. If we view our patients by the homeostasis principle, as already noted, it forces us to achieve consistency in therapeutic interventions and thus discredit different dosing schedules, that is, morning versus evening, as inconsequential with regard to either the pharmokinetics or the therapeutic results of a drug. As will become evident during this discussion, for respiratory diseases and therapeutic interventions this is not the case. Additionally, we are also learning that many if not all of the different organ systems in the body have circadian (occurring over a 24-hour cycle) changes in function and thus we will benefit from understanding specific diseases by a chronobiologic as well as a chronotherapeutic approach.

show abstract

Effect of Therapeutic Theophylline Levels on the Sleep Quality and Daytime Cognitive Performance of Normal Subjects

Cited by 33 publications

References 9 publications

Effects of Theophylline on Nocturnal Sleep and Daytime Sleepiness/Alertness

Effects of Theophylline on Nocturnal Sleep and Daytime Sleepiness/Alertness

Salmeterol vs Theophylline

Chronotherapy of Asthma: How to Use Standard Medications for Better Results

Contact Info

Product

Resources

About