Effect of theophylline and terbutaline on immediate skin tests

Chipps, Bradley E.; Sobotka, Anne K.; Sanders, J. P.; Teets, Katherine C.; Norman, Philip S.; Lichtenstein, Lawrence M.

doi:10.1016/0091-6749(80)90178-5

Cited by 23 publications

(3 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…inhibition of mediator release and permeability changes, are, as expected, counteracted by propranolol [3,9] and might be of therapeutic interest in allergic asthma and add to the bronchodilator capacity of the drugs. In contrast to the demonstrated suppression of allergen-elicited cutaneous reactions by topically applied drugs, therapeutically relevant concentrations of terbutaline, theophylline and their combination lack attenuating capacity in this respect [11,12]. It is conceivable that the demonstrated anti-allergic effect of theophylline and salbutamol was accomplished due to a more favourable relation between concentration of allergen and drugs at the challenged skin site.…”

Section: Discussionmentioning

confidence: 93%

Inhibition of allergen-induced early reactions in atopic skin by salbutamol and theophylline

Grönneberg

1985

Agents and Actions

View full text Add to dashboard Cite

The possible antagonistic effect of the beta 2-adrenoceptor agonist salbutamol and the methylxanthine theophylline on allergen-induced immediate skin reactions was elucidated. Dose-dependent reductions of early allergen-induced responses (flare and weal) were produced in eight atopic patients by salbutamol, 2.5 ng-1 micrograms (p less than 0.001). Theophylline attenuated these responses only at a high dose, 100 micrograms (p less than 0.01). Histamine-induced flare responses were not influenced by these agents, but wealing was inhibited by 35% by 1 microgram of salbutamol (p less than 0.001). It is concluded that agents which interact with anaphylactic histamine release and elevate cyclic AMP level in heterogeneous tissues in vitro have similar counteracting effects on allergen-induced skin reactions in atopic subjects.

show abstract

Section: Discussionmentioning

confidence: 93%

Inhibition of allergen-induced early reactions in atopic skin by salbutamol and theophylline

Grönneberg

1985

Agents and Actions

View full text Add to dashboard Cite

show abstract

“…Systemically administered jS2-agonists, theophylline and corticosteroids have previously been shown to have no influence on the skin response to either intradermal antigen or histamine [1][2][3][4]. However, if the area of skin to be challenged is pre-treated with an injection of a jS2-agonist, then this high local concentration attenuates the response to intradermal antigen [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Systemic adrenaline attenuates skin response to antigen and histamine

Warren

McCusker

Fuller

1988

Clin Experimental Allergy

View full text Add to dashboard Cite

Summary Six atopic subjects received either adrenaline (0.3 ml of 1 mg/ml), subcutaneously over the deltoid muscle, or saline on 2 separate days. After 10 min, histamine and antigen were injected intradermally in the forearm. Adrenaline significantly inhibited the flare of histamine and both the flare and weal of antigen (P< 0.05). This anti‐allergic action of adrenaline occurred with a dose that we have previously shown produces plasma concentrations at the upper limit of the physiological range in resting normal subjects.

show abstract

“…Many medications are known to have an effect on intradermal skin testing, including theophylline, ␤ 2 -agonists, prochlorperazine, some sedatives, and antihistamines. [14][15][16] These agents must be stopped before skin testing to obtain reliable results.…”

mentioning

confidence: 99%