Effect of theanine, γ‐glutamylethylamide, on bodyweight and fat accumulation in mice

Zheng, Guodong; Bamba, Kimio; Ōkubo, Tsutomu; Juneja, Lekh Raj; Oguni, Itaro; Sayama, Kazutoshi

doi:10.1111/j.1740-0929.2005.00251.x

Cited by 30 publications

(32 citation statements)

References 19 publications

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“…Moreover, ICR mice are outbred and genetically heterogeneous mice, which are commonly not used for studies in obesity research. Additionally, it appears that the mice were fed a regular, low-fat diet, which in most mouse models does not lead to the development of obesity, especially when given at a young age as in the described study [50]. Therefore, the animal model chosen in this study might not be appropriate for investigation of anti-obesity effects.…”

Section: Anti-obesity Effects Of Green Teamentioning

confidence: 89%

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Anti‐obesity effects of green tea: From bedside to bench

Wolfram¹,

Wang²,

Thielecke³

2006

Molecular Nutrition Food Res

387

261

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During the last decade, the traditional notion that green tea consumption benefits health has received significant scientific attention and, particularly, the areas of cardiovascular disease and cancer were subject to numerous studies. Due to the ever-growing obesity pandemic, the anti-obesity effects of green tea are being increasingly investigated in cell, animal, and human studies. Green tea, green tea catechins, and epigallocatechin gallate (EGCG) have been demonstrated in cell culture and animal models of obesity to reduce adipocyte differentiation and proliferation, lipogenesis, fat mass, body weight, fat absorption, plasma levels of triglycerides, free fatty acids, cholesterol, glucose, insulin and leptin, as well as to increase beta-oxidation and thermogenesis. Adipose tissue, liver, intestine, and skeletal muscle are target organs of green tea, mediating its anti-obesity effects. Studies conducted with human subjects report reduced body weight and body fat, as well as increased fat oxidation and thermogenesis and thereby confirm findings in cell culture systems and animal models of obesity. There is still a need for well-designed and controlled clinical studies to validate the existing and encouraging human studies. Since EGCG is regarded as the most active component of green tea, its specific effects on obesity should also be investigated in human trials.

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Section: Anti-obesity Effects Of Green Teamentioning

confidence: 89%

“…In ICR mice, the effects of different green tea components were investigated [50]. Caffeine and theanine suppressed body weight and body fat, while catechins did not change these parameters but reduced serum triglycerides and free fatty acids.…”

Section: Anti-obesity Effects Of Green Teamentioning

confidence: 99%

Anti‐obesity effects of green tea: From bedside to bench

Wolfram¹,

Wang²,

Thielecke³

2006

Molecular Nutrition Food Res

387

261

View full text Add to dashboard Cite

show abstract

“…At 100 lM, EGCG also inhibited the activity of two other cholesterol-biosynthetic enzymes, lanosterol 14a-demethylase and oxidosqualene:lanosterol cyclase [68]. Together with the inhibition of micelle formation [56] and the stimulation of fecal cholesterol excretion [32,38] by EGCG as discussed in Section 3.1, EGCG's inhibition of cholesterol-biosynthetic enzymes may be related to the low plasma cholesterol levels observed in rats IP-injected with EGCG [18]. Interestingly, an in vivo study [69] shows that no effect of green tea on the activity of HMG-CoA reductase and cholesterol 7a-hydroxylase was observed, suggesting the selective effect of green tea or EGCG on the cholesterol-biosynthetic enzymes.…”

Section: Inhibition Of Lipogenic Enzymesmentioning

confidence: 90%

Tea, obesity, and diabetes

Kao¹,

Chang

Lee

et al. 2006

Molecular Nutrition Food Res

291

204

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Tea has been found to possess widespread biological functions based on a variety of laboratory data. The effects of tea on obesity and diabetes have received increasing attention. This paper reviews the evidence for the connections among tea catechins, and obesity and diabetes. Tea catechins, especially (-)-epigallocatechin gallate (EGCG), appear to have antiobesity and antidiabetic effects. While few epidemiological and clinical studies show the health benefits of EGCG on obesity and diabetes, the mechanisms of its actions are emerging based on the various laboratory data. These mechanisms may be related to certain pathways, such as through the modulations of energy balance, endocrine systems, food intake, lipid and carbohydrate metabolism, the redox status, and activities of different types of cells (i. e., fat, liver, muscle, and beta-pancreatic cells). Because the EGCG receptor, the so-called 67-kDa laminin receptor (LR), has been discovered with colocalization of other types of LR and cytoskeleton in both cancer cells and normal cells, this may explain that EGCG possesses numerous actions. The mechanistic results of this review may possibly be utilized in the treatment of obesity, diabetes, and other related diseases using tea- and EGCG-based folk medicines.

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“…Caffeine has been demonstrated to reduce the weight of adipose tissues in experimental animals (Hasegawa and Mori, 2000;Zheng et al, 2004). Kobayashi-Hattori et al (2005) have shown that the intake of caffeine elevated the serum level of catecholamine in rats fed a high fat diet, and they presumed that the enhancement of the production of catecholamine accelerated lipolysis.…”

Section: Cumulationmentioning

confidence: 99%

“…Raw green coffee beans, which are materials of coffee, are rich in caffeine, chlorogenic acid, and its related components, such as quinic acid, caffeic acid, and p-coumaric acid. Caffeine has been reported to promote lipolysis in adipocytes of experimental animals and humans (Hasegawa and Mori, 2000;Zheng et al, 2004;LopezGarcia et al, 2006). Kobayashi-Hattori et al (2005) has observed that caffeine reduced body fat mass and body fat percentage in a dose-dependent manner in rats fed high-fat diets.…”

Section: Introductionmentioning

confidence: 99%

Anti-Obesity and Hypotriglyceridemic Properties of Coffee Bean Extract in SD Rats

Tanaka

Nishizono

Tamaru

et al. 2009

FSTR

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Coffee bean extract (CBE) was prepared from raw green coffee beans and contained 10.0% caffeine and 27.0% chlorogenic acid. Male Sprague-Dawley rats were fed a diet containing 1% CBE for 4 weeks. Although there was no difference in food intake between rats fed the control diet without CBE and those fed the CBE-containing diet, body weight gain and white adipose tissue weight were significantly decreased in CBE-fed rats than in control rats. The CBE-fed group exerted a significant and extreme reduction in serum and liver triglyceride concentrations compared to the control group. Also, in the CBE-fed group, activities of fatty acid synthetic enzymes in the hepatic cytosol were significantly decreased, while that of fatty acid oxidative enzymes in the hepatic mitochondria was significantly increased. Our results suggest that CBE has potent anti-obesity and hypotriglyceridemic properties, and there is a possibility that these effects are exerted at least in part by the suppression of lipogenesis and the acceleration of lipolysis.

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Effect of theanine, γ‐glutamylethylamide, on bodyweight and fat accumulation in mice

Cited by 30 publications

References 19 publications

Anti‐obesity effects of green tea: From bedside to bench

Anti‐obesity effects of green tea: From bedside to bench

Tea, obesity, and diabetes

Anti-Obesity and Hypotriglyceridemic Properties of Coffee Bean Extract in SD Rats

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