Effect of the vascular endothelium on noradrenaline‐induced contractions in non‐pregnant and pregnant guinea‐pig uterine arteries

Jovanović, Aleksandar; Grbović, Leposava; Jovanović, Sofija

doi:10.1111/j.1476-5381.1995.tb13276.x

Cited by 21 publications

(3 citation statements)

References 44 publications

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“…This may be due to the high intrinsic activity of acetylcholine that may result in difficulties to block NO‐synthase activity in the presence of such a strong agonist (Jovanović et al., 1994c). The release of a, yet unidentified, endothelium‐dependent relaxant factor may also be alternatively possible (Jovanović et al., 1995b).…”

Section: Discussionmentioning

confidence: 99%

Endothelium‐dependent Relaxation of Canine Uterine Artery in Response to Acetylcholine: the Possible Involvement of Alternative Pathways

Pesic

Grbović

Jovanović

et al. 2003

Journal of Veterinary Medicine Series A

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The effect of acetylcholine on the isolated, pre-contracted, uterine artery of non-pregnant dog was investigated. Acetylcholine-induced concentration-dependent relaxation of isolated canine uterine artery with endothelium (pEC50 = 6.48 +/-0.01, n = 37) and was without effect on arterial segments denuded of endothelium. Indomethacin, 4-aminopyridine (10-5 m) and pre-contraction with K+-rich Krebs-Ringer bicarbonate solution had no effect on acetylcholine-induced relaxation. NG-nitro-l-arginine (l-NOARG) (10-5 m) inhibited relaxation evoked by acetylcholine. Indomethacin applied with l-NOARG led to further inhibition of acetylcholine-induced relaxation. In the presence of both l-NOARG and indomethacin, 4-aminopiridine did not provoke further inhibition of acetylcholine-induced relaxation of canine uterine artery. It is concluded that the acetylcholine-induced relaxation of canine uterine artery is probably mediated by endothelial production of nitric oxide (NO). However, if NO-synthase is inhibited, acetylcholine-induced vasorelaxation may be, in part, mediated through activation of cyclooxygenase pathway.

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Section: Discussionmentioning

confidence: 99%

Endothelium‐dependent Relaxation of Canine Uterine Artery in Response to Acetylcholine: the Possible Involvement of Alternative Pathways

Pesic

Grbović

Jovanović

et al. 2003

Journal of Veterinary Medicine Series A

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“…The increased α 2 -mediated vasorelaxation was dependent on the endothelium and nitric oxide synthase (NOS). Several studies in isolated uterine arteries from pregnant humans and various experimental animal models [51][52][53][54][55][56][57] have demonstrated that endothelium-dependent and independent pathways play increased roles in buffering adrenergic receptor-induced vasoconstriction in pregnant versus non-pregnant groups. These enhanced vasodilatory and vasoconstriction-buffering mechanisms are mediated by increased NOS, vascular smooth muscle cell responsiveness to vasodilators, and reduced capacity of the smooth muscle layer to depolarize [54,58].…”

Section: Mechanisms To Buffer Sna-mediated Control Of Maternal Hemodynamics During Normal Pregnancymentioning

confidence: 99%

Sympathetic nervous system control of vascular function and blood pressure during pregnancy and preeclampsia

Spradley

2019

Journal of Hypertension

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: Proper vascular tone and blood pressure regulation during pregnancy are important for immediate and long-term cardiovascular health of the mother and her offspring. Preeclampsia is clinically defined as new-onset maternal hypertension accompanied by cardiovascular, renal, and/or neural abnormalities presenting in the second half of pregnancy. There is strong evidence to support that preeclampsia is mediated by attenuations in uteroplacental vascular remodeling and increases in vasoconstriction with subsequent placental ischemia/reperfusion-induced release of hypertensive substances into the maternal circulation. These include antiangiogenic and pro-inflammatory factors. There is also evidence implicating increased sympathetic nervous system activity (SNA) in this maternal disorder, but this mostly includes data correlating severity of disease with catecholamine levels and elevated muscle SNA. These measurements have not confirmed a causative role for SNA in the pathogenesis of preeclampsia. Therefore, studies are needed to provide a comprehensive understanding of SNA and its control of vascular function and blood pressure regulation during normal pregnancy in order to set the stage for exploring the mechanisms mediating the exaggerated SNA and signaling during preeclampsia. This review examines the role of SNA in control of uteroplacental vascular tone and blood pressure regulation during normal pregnancy. Furthermore, it is proposed that over-activation of the SNA contributes to altered uteroplacental vascular tone and perfusion leading to placental ischemic events and modulates the systemic vasoconstriction and hypertensive responses to soluble placenta ischemic factors. Recognizing the integrative role and importance of SNA in the pathophysiology of preeclampsia will advance our understanding of this maternal disorder.

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“…It is known that cardiac output is increased during pregnancy, which is associated with increased rates of perfusion to both reproductive and non-reproductive organs (Rosenfeld, 1977). This vascular adaptation of mothers to pregnancy is considered to be due to blunted vascular response to vasoconstrictors on the one hand (Weiner et al, 1991;Grbovic ´and Jovanovic ´, 1996Jovanovic ´et al, 1998b), and increased response to vasodilators on the other (Weiner et al, 1989), although this concept has been repeatedly challenged (Jovanovic ´et al, 1994a(Jovanovic ´et al, , 1995a(Jovanovic ´et al, ,b,c, 1997.…”

Section: Introductionmentioning

confidence: 99%

Pregnancy is not associated with altered morphology of the femoral artery

Jovanović¹,

Blagojević²,

Mrvić³

et al. 1999

Human Reproduction

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While pregnancy is associated with adjustments in cardiovascular function, the morphology of the vascular system during pregnancy has been generally viewed as being very stable. However, recently we have demonstrated that pregnancy remodels the aorta and the carotid artery. In the present study, we assessed the morphological characteristics of the guinea-pig femoral artery during different stages of pregnancy using light and electron microscopy. There were no significant differences between external and internal diameters, wall thickness, total cross-sectional area and cross-sectional areas of lumen, intima, media, and adventitia of femoral arteries from non-pregnant and early-, mid- and late-pregnant guinea-pigs (n = 8-10). In previous studies, we have shown that the morphology of vascular smooth muscle and endothelial cells in the aorta and the carotid artery may be altered by pregnancy. Therefore, to test this possibility we measured diameters as well as cross-sectional areas of femoral arterial muscle and endothelial cells using electron microscopy. These parameters, at the electron microscopy level, were also not significantly changed by pregnancy (n = 8-10). It is concluded that the morphology of the guinea-pig femoral artery is not altered during pregnancy. In this regard, this study demonstrated that pregnancy-induced vascular remodelling varies between blood vessels that undergo the same functional alterations. Therefore, this may suggest that pregnancy-induced changes in blood flow through different vascular beds are not the most important factor involved in vascular remodelling observed during pregnancy. Rather, it is possible that haemodynamic-independent factors regulate pregnancy-mediated structural changes of the vascular wall.

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Effect of the vascular endothelium on noradrenaline‐induced contractions in non‐pregnant and pregnant guinea‐pig uterine arteries

Cited by 21 publications

References 44 publications

Endothelium‐dependent Relaxation of Canine Uterine Artery in Response to Acetylcholine: the Possible Involvement of Alternative Pathways

Endothelium‐dependent Relaxation of Canine Uterine Artery in Response to Acetylcholine: the Possible Involvement of Alternative Pathways

Sympathetic nervous system control of vascular function and blood pressure during pregnancy and preeclampsia

Pregnancy is not associated with altered morphology of the femoral artery

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